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Coronavirus Intel Clearinghouse
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In accordance with industry accepted best practices we ask that users limit their copy / paste of copyrighted material to the relevant portions of the article you wish to discuss and no more than 50% of the source material, provide a link back to the original article and provide your original comments / criticism in your post with the article.
[quote:Anonymous Coward 75327296:MV80MjYwNTg2Xzc3NjYwMDI4X0JCQzVBN0I0] [quote:Anonymous Coward 78402365:MV80MjYwNTg2Xzc3NjUyNjkzXzI2Qzc2OTFF] [quote:Bodiless:MV80MjYwNTg2Xzc3NjUwODgxXzcxNDVEQ0Yy] [quote:Anonymous Coward 75833332:MV80MjYwNTg2Xzc3NjMzMjAzX0M3RjBFODRF] [quote:Anonymous Coward 75214035:MV80MjYwNTg2Xzc3NjMyNjA2XzgyRkQzNzg=] OP, I’m not a medical professional. However, based on my “layman” research, it’s clear that this virus is similar to SARS in many respects. I’m finding conflicting information in the matter of ACE-2 that I’m hoping you may clarify. I’m finding some articles advocating for increasing ACE2 levels to protect against lowered values caused by infection, yet other articles seem to indicate that inhibition of ACE-2 helps to prevent infection. Can you please offer your insights and recommendations? Thanks in advance. I’m tracking this thread several times a day for updates. . [/quote] [quote:Anonymous Coward 78455686:MV80MjYwNTg2Xzc3NjMyNzU2Xzc0OUE0RDBB] Hello 011, from another thread: [b]The wuhan virus is identical to the ACE2 key-- and it fits into the keyhole. So-- flooding the body with ACE2 would be a means of sopping up the virus-- NOT inhibiting ACE2.[/b] What's your take on that.. some suggested ACE2 inhibitors, but this person thinks it could make matters worse. [/quote] ^^these!! Would taking an ACE inhibitor for already high blood pressure be beneficial or problematic? [/quote] The ACE2 receptor is merely the route of ingress of NCoV INTO the cell—it does nothing else. Overdosing on ACE2 inhibitor meds would have very serious cardiovascular/vasopressin results. I would recommend NOT doing this. Same with ARBs, the receptor site(ACE2) is complex. Wish it were Once inside the cell it disables the Tregulator cells which is what is used to inhibit the positive feedback loop cytokines storm Vit D plays a part in the formulation/differentiation of the myloproliferative cell into a Tregulator cell [/quote] ACE2 is also not the only receptor that it is using, this is just me and my colleagues coming to this possibility. Our lab has not studied transmission or much of anything related to such. But just from provided facts here vs information regarding other viruses known to utilize ACE2 receptors, it just does not click. SARS is known and proven to use ACE2 only. Ncov is reported, to use ACE2 "only". Sars, 13 months, less lethal by far, less infectious. Ncov is clearly able to enter by other means, atleast I have come to accept this myself. Medications/methods to prevent infection are priority 1. Treatment is secondary in nature as you would hope prevention is successful. Remdesivir is still being touted in media, disregarding the fact it has adverse, unstudied side effects that are disregarded as this is an antiviral used in HIV cases. It is intended to stop RNA based viral replication, it does do its job as intended, but it is neither effective enough or safe enough to use as a fulltime treatment. -001 [/quote] Is the plan to put the entire planet on Anti-Virals or some other type of preventive treatments? That would not be feasible nor possible. You discussed many times that vaccines could not be developed due to mutation rates etc. So what would prevent infection that is in the FDA toolbox? Also, have to go through your posts I’ve cataloged, but thought you said that treatment was priority 1? Has something changed? [/quote]
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