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07:51 PM
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Coronavirus Intel Clearinghouse
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[quote:Anonymous Coward 78322848:MV80MjYwNTg2Xzc3NjA2NzcyXzg5MDMwNjE2] [quote:Anonymous Coward 78442136:MV80MjYwNTg2Xzc3NjAyMDE1X0NCMTBCNUUx] 001, can you please comment on this : [i]" Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration. [b]The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90uM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500mg administration.[/b]" [/i] ...or is it false hope? [/quote] Sounds certainly hopeful! Can you please provide the quote source? BTW, I'm not 001. [/quote]
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The purpose of this thread is being changed to include all reports of private information members may come across. If you have medical, military, law enforcement, first-hand accounts, etc, please post them here.
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