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COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects /// October Lockdown for UK (pg. 774)
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[quote:Anonymous Coward 79356258:MV80NDc5ODAxXzg3MDQ2MjcyXzhCRTE1NzMy] Sinovac has a different approach - not making the whole spike. [quote:S-man:MV80NzIxMzM3Xzg2NjUyNzA0X0MzOTc5NTU0] Another ...RED ALERT...?! I am thinking about the problem of the vaccines having the spike and making prions... and WHY the Chinese would vaccinate their own if they knew.. This is the literature I have found about Sinovac/Coronavac. They are INACTIVATED viruses. Remember, [b][color=red]the prion-genesis site is at position 500 on the spike, well within the S1 domain[/b][/color]. [b]Below, the literature shows the [color=red]S1 protein is cleaved off[/color] in the inactivated virus vaccines![/b] https://www.biorxiv.org/content/10.1101/2021.01.15.426463v1.full Both Moderna’s mRNA-1273 and Pfizer’s BNT162b2 (7) encodes full length S with two mutations to stabilise [b]the prefusion conformation[/b] (8), and Sinovac’s CoronaVac inactivated virus vaccine presents the wild-type S on the viral surface (9), although the majority of [b]spikes are in the postfusion conformation[/b] (10). https://www.ndm.ox.ac.uk/publications/1138385 [b]The Architecture of [color=red]Inactivated[/color] SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET.[/b] Although a small fraction of prefusion spikes are found, most spikes appear nail shaped, thus resembling a postfusion state, [b][color=red]where the S1 protein of the spike has disassociated from S2[/b][/color] https://www.cell.com/structure/fulltext/S0969-2126(20)30372-5 There is consensus that the engagement of the S1 RBD with the receptor destabilizes the trimer, triggering the shedding of the S1 units, which allows a remarkable conformational change in the spike from a large club-shaped structure into a thin and long nail-like structure. [/quote] [/quote]
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