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COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects /// October Lockdown for UK (pg. 774)
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[quote:Anonymous Coward 80683600:MV80NDc5ODAxXzg4ODE4MDk4X0M0MTc0RDBC] [quote:CoronaCoaster:MV80NDc5ODAxXzg4ODE3OTI3X0UwRUVBMjg4] [quote:ShylaRose:MV80NDc5ODAxXzg4ODA0MzI4XzUyMTNCQzkx] SAGE paper https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1007566/S1335_Long_term_evolution_of_SARS-CoV-2.pdf [/quote] One of the interesting possibilities they bring up(altho considered less likely by them for now) is 'antigenic sin' which sounds rather like ADE? quote [b]Antigenic sin (vaccination resulting in an immune response that is dominated by antibodies to previously experienced viruses/vaccines) meaning that it becomes difficult to revaccinate to induce antibodies to the new strains.[/b] :verydamned: [/quote] New one on me.... antigenic sin leads to ADE, if I read correctly... [b]Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS [/b] Less than 50% In conclusion, the development of IgG against SARS-CoV-2 in the course of COVID-19 might not be a simple sign of viral clearance and developing protection against the virus. On the contrary, due to cross-reaction to related coronavirus strains from earlier infections, the patient's viral history of coronavirus infection might be crucial to the severity of the course of the current infection with SARS-CoV-2, a phenomenon that has been called in the context of influence infections “original antigenic sin.” Furthermore, it poses a note of caution when treating COVID-19 patients with convalescent sera. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291596/ [/quote]
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