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Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism

 
Face Palmer
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02/28/2014 03:33 AM
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Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Finding May Explain Many Brain Disorders, Lead to Prevention and Treatment

A new study led by Weill Cornell Medical College scientists shows that the most common genetic form of mental retardation and autism occurs because of a mechanism that shuts off the gene associated with the disease. The findings, published today in Science, also show that a drug that blocks this silencing mechanism can prevent fragile X syndrome — suggesting similar therapy is possible for 20 other diseases that range from mental retardation to multisystem failure.

Fragile X syndrome occurs mostly in boys, causing intellectual disability as well as telltale physical, behavioral and emotional traits. While researchers have known for more than two decades that the culprit behind the disease is an unusual mutation characterized by the excess repetition of a particular segment of the genetic code, they weren't sure why the presence of a large number of these repetitions — 200 or more — sets the disease process in motion.

Using stem cells from donated human embryos that tested positive for fragile X syndrome, the scientists discovered that early on in fetal development, messenger RNA — a template for protein production — begins sticking itself onto the fragile X syndrome gene's DNA. This binding appears to gum up the gene, making it inactive and unable to produce a protein crucial to the transmission of signals between brain cells.

[link to weill.cornell.edu]

Last Edited by Face Palmer on 02/28/2014 04:08 AM
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Anonymous Coward
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02/28/2014 03:38 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Your topics are always so good!

I wonder if the GMO crap has something to do with this. I mean NO one heard of autism when I was a kid. And that was only 20 years ago or so. Now it's prevalent and normal! That's not right! It's either the GMO food or the aggressive vaccines we're pushing on infants these days.

Something is definitely working against nature here.
Face Palmer  (OP)

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02/28/2014 03:51 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Something is definitely working against nature here.
 Quoting: calx


Yeah. Its us. We do. And we will reap what we sow.
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Watdhel

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02/28/2014 03:58 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Your topics are always so good!

I wonder if the GMO crap has something to do with this. I mean NO one heard of autism when I was a kid. And that was only 20 years ago or so. Now it's prevalent and normal! That's not right! It's either the GMO food or the aggressive vaccines we're pushing on infants these days.

Something is definitely working against nature here.
 Quoting: calx


Yep, rare & almost non existent with in Amish communities!
Anonymous Coward
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02/28/2014 03:59 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Something is definitely working against nature here.
 Quoting: calx


Yeah. Its us. We do. And we will reap what we sow.
 Quoting: Face Palmer


Have you read anything by Daniel Quinn?

[link to en.wikipedia.org]

Ishmael and The Story of B resonated with me. They were about the basic two civilizations on earth - the leavers and the takers.

He has an agenda against Western progress and I agree with him to a point. The leavers are the tribal groups who live peacefully with nature and the takers are with the "dominate the earth" West.

The only problem is that humans are too damn inherently greedy I think. We've squandered our resources and created a paradigm of scarcity and that's not true at all. We can all live in harmony here with human expansion and technology. I don't know how many humans the earth can handle but we should be living here at a safe and symbiotic level here as we are in the present.

The only reason why Tesla's work was suppressed was that JP Morgan saw no money in his inventions. That's fucked. Gotta make a buck. True progress denied for the sake of power by the psychopathic families that have ruled here since time immemorial.

Money isn't the root of all evil but the love of power and conquest is. We're flawed. And we've been born here again and again.

I wonder how the story will end this time.

I love stories! :D
Face Palmer  (OP)

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02/28/2014 04:01 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Something is definitely working against nature here.
 Quoting: calx


Yeah. Its us. We do. And we will reap what we sow.
 Quoting: Face Palmer


Have you read anything by Daniel Quinn?

[link to en.wikipedia.org]

Ishmael and The Story of B resonated with me. They were about the basic two civilizations on earth - the leavers and the takers.

 Quoting: calx


Never heard of it, but it sounds like a book the Face Palmer might like. :)
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Anonymous Coward
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02/28/2014 04:02 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Something is definitely working against nature here.
 Quoting: calx


Yeah. Its us. We do. And we will reap what we sow.
 Quoting: Face Palmer


Have you read anything by Daniel Quinn?

[link to en.wikipedia.org]

Ishmael and The Story of B resonated with me. They were about the basic two civilizations on earth - the leavers and the takers.

 Quoting: calx


Never heard of it, but it sounds like a book the Face Palmer might like. :)
 Quoting: Face Palmer


I really recommend them. Also I'm gonna pin this topic if you don't mind. :)
Face Palmer  (OP)

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02/28/2014 04:06 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
...


Yeah. Its us. We do. And we will reap what we sow.
 Quoting: Face Palmer


Have you read anything by Daniel Quinn?

[link to en.wikipedia.org]

Ishmael and The Story of B resonated with me. They were about the basic two civilizations on earth - the leavers and the takers.

 Quoting: calx


Never heard of it, but it sounds like a book the Face Palmer might like. :)
 Quoting: Face Palmer


I really recommend them. Also I'm gonna pin this topic if you don't mind. :)
 Quoting: calx


Google has em. I will download to my Kindle when i'm home. Thanks for pinning. hf
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Anonymous Coward
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02/28/2014 04:07 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
...


Have you read anything by Daniel Quinn?

[link to en.wikipedia.org]

Ishmael and The Story of B resonated with me. They were about the basic two civilizations on earth - the leavers and the takers.

 Quoting: calx


Never heard of it, but it sounds like a book the Face Palmer might like. :)
 Quoting: Face Palmer


I really recommend them. Also I'm gonna pin this topic if you don't mind. :)
 Quoting: calx


Google has em. I will download to my Kindle when i'm home. Thanks for pinning. hf
 Quoting: Face Palmer


You are quite welcome! :D
Nachos

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02/28/2014 05:55 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
i was recently officially diagnosed with autism. please, someone fix my "mental retardation" i don't like being a retard fullretard1
Judethz

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02/28/2014 06:00 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Something is definitely working against nature here.
 Quoting: calx


Yep, rare & almost non existent with in Amish communities!
 Quoting: Watdhel


kitty Mal 2:3 Behold, I will corrupt your seed, and spread dung upon your faces, even the dung of your solemn feasts; and one shall take you away with it.
Anonymous Coward
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02/28/2014 06:25 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Vaccines, GMO, and exposure to vynel and PVC.
FlashBuzzkill

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02/28/2014 06:28 AM

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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Truly sad what we've done to the younger generations, perhaps unknowingly, perhaps not.

It seems our race for profits trumps all else, including sanity.

When I was a kid 40 years not only was autism unheard of but fat people were pretty rare too. This could end well but given human nature I have my doubts.

Last Edited by FlashBuzzkill on 02/28/2014 06:28 AM
Gen. John B Gordon and Gen. Nathan Bedford Forrest were the finest citizen-soldiers birthed in America.
Nachos

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02/28/2014 06:34 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Vaccines, GMO, and exposure to vynel and PVC.
 Quoting: Anonymous Coward 12262479


1doh1
Anonymous Coward
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02/28/2014 06:56 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Something is definitely working against nature here.
 Quoting: calx


Yeah. Its us. We do. And we will reap what we sow.
 Quoting: Face Palmer


Have you read anything by Daniel Quinn?

[link to en.wikipedia.org]

Ishmael and The Story of B resonated with me. They were about the basic two civilizations on earth - the leavers and the takers.

He has an agenda against Western progress and I agree with him to a point. The leavers are the tribal groups who live peacefully with nature and the takers are with the "dominate the earth" West.

The only problem is that humans are too damn inherently greedy I think. We've squandered our resources and created a paradigm of scarcity and that's not true at all. We can all live in harmony here with human expansion and technology. I don't know how many humans the earth can handle but we should be living here at a safe and symbiotic level here as we are in the present.

The only reason why Tesla's work was suppressed was that JP Morgan saw no money in his inventions. That's fucked. Gotta make a buck. True progress denied for the sake of power by the psychopathic families that have ruled here since time immemorial.

Money isn't the root of all evil but the love of power and conquest is. We're flawed. And we've been born here again and again.

I wonder how the story will end this time.

I love stories! :D
 Quoting: calx


hesright
Anonymous Coward
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02/28/2014 07:35 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
[

The only problem is that humans are too damn inherently greedy I think.
 Quoting: calx


You may wish to research "potlatch"
Anonymous Coward
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02/28/2014 07:48 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Your topics are always so good!

I wonder if the GMO crap has something to do with this. I mean NO one heard of autism when I was a kid. And that was only 20 years ago or so. Now it's prevalent and normal! That's not right! It's either the GMO food or the aggressive vaccines we're pushing on infants these days.

Something is definitely working against nature here.
 Quoting: calx


Yep, rare & almost non existent with in Amish communities!
 Quoting: Watdhel


Yeah but dwarfism runs through the community.
Anonymous Coward
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02/28/2014 07:54 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Or they could just focus on fixing vitamin D deficiency.

Activated vitamin D (neurosteroid hormone called calcitriol) is basically DNA repair and maintenance.
Anonymous Coward
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02/28/2014 08:09 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Your topics are always so good!

I wonder if the GMO crap has something to do with this. I mean NO one heard of autism when I was a kid. And that was only 20 years ago or so. Now it's prevalent and normal! That's not right! It's either the GMO food or the aggressive vaccines we're pushing on infants these days.

Something is definitely working against nature here.
 Quoting: calx


Plastic bottles,

And it's 30 years ago, when glass bottles were widely used.

Also,

Microwaving plastics,
Let's say that one again,
Microwaving plastics !

PCB's
Dielectric oils
Oubliette

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02/28/2014 08:10 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Your topics are always so good!

I wonder if the GMO crap has something to do with this. I mean NO one heard of autism when I was a kid. And that was only 20 years ago or so. Now it's prevalent and normal! That's not right! It's either the GMO food or the aggressive vaccines we're pushing on infants these days.

Something is definitely working against nature here.
 Quoting: calx


Yep, rare & almost non existent with in Amish communities!
 Quoting: Watdhel


That's not true. Amish actually have a high incidence of Fragile X.
This is an oubliette. The labyrinth is full of 'em.
Anonymous Coward
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02/28/2014 08:15 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Vaccines, GMO, and exposure to vynel and PVC.
 Quoting: Anonymous Coward 12262479


[link to www.dogsadversereactions.com]

A team at Purdue University School of Veterinary Medicine conducted several studies (1,2) to determine if vaccines can cause changes in the immune system of dogs that might lead to life-threatening immune-mediated diseases. They obviously conducted this research because concern already existed. It was sponsored by the Haywood Foundation which itself was looking for evidence that such changes in the human immune system might also be vaccine induced. It found the evidence.

The vaccinated, but not the non-vaccinated, dogs in the Purdue studies developed autoantibodies to many of their own biochemicals, including fibronectin, laminin, DNA, albumin, cytochrome C, cardiolipin and collagen.

Perhaps most worryingly, the Purdue studies found that the vaccinated dogs had developed autoantibodies to their own DNA. Did the alarm bells sound? Did the scientific community call a halt to the vaccination program? No. Instead, they stuck their fingers in the air, saying more research is needed to ascertain whether vaccines can cause genetic damage.



Then, in 2000, CHC's findings were confirmed by research which showed that polyarthritis and other diseases like amyloidosis, which affects organs in dogs, were linked to the combined vaccine given to dogs.(8) There is a huge body of research, despite the paucity of funding from the vaccine industry, to confirm that vaccines can cause a wide range of brain and central nervous system damage. Merck itself states in its Manual that vaccines (i.e., its own products) can cause encephalitis: brain inflammation/damage. In some cases, encephalitis involves lesions in the brain and throughout the central nervous system. Merck states that "examples are the encephalitides following measles, chickenpox, rubella, smallpox vaccination, vaccinia, and many other less well defined viral infections".

When the dog owners who took part in the CHC survey reported that their dogs developed short attention spans, 73.1% of the dogs did so within three months of a vaccine event. The same percentage of dogs was diagnosed with epilepsy within three months of a shot (but usually within days). We also found that 72.5% of dogs that were considered by their owners to be nervous and of a worrying disposition, first exhibited these traits within the three-month post-vaccination period.
Anonymous Coward
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02/28/2014 08:15 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Your topics are always so good!

I wonder if the GMO crap has something to do with this. I mean NO one heard of autism when I was a kid. And that was only 20 years ago or so. Now it's prevalent and normal! That's not right! It's either the GMO food or the aggressive vaccines we're pushing on infants these days.

Something is definitely working against nature here.
 Quoting: calx



Only 20 years or so ago since you were a kid? I had you pegged as much older than that! chuckle
Oubliette

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02/28/2014 08:17 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Your topics are always so good!

I wonder if the GMO crap has something to do with this. I mean NO one heard of autism when I was a kid. And that was only 20 years ago or so. Now it's prevalent and normal! That's not right! It's either the GMO food or the aggressive vaccines we're pushing on infants these days.

Something is definitely working against nature here.
 Quoting: calx


The diagnostic criteria for autism has changed greatly over the last 20 years. It includes a lot more people, especially on the higher functioning end of the spectrum. So of course cases will increase because of that.

Way back when, most of what would be autism cases now, woukd have either been diagnosed as mental retardation, or perhaps the child would be labeled "slow" or "strange".
This is an oubliette. The labyrinth is full of 'em.
Anonymous Coward
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02/28/2014 08:23 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Finding May Explain Many Brain Disorders, Lead to Prevention and Treatment

A new study led by Weill Cornell Medical College scientists shows that the most common genetic form of mental retardation and autism occurs because of a mechanism that shuts off the gene associated with the disease. The findings, published today in Science, also show that a drug that blocks this silencing mechanism can prevent fragile X syndrome — suggesting similar therapy is possible for 20 other diseases that range from mental retardation to multisystem failure.

Fragile X syndrome occurs mostly in boys, causing intellectual disability as well as telltale physical, behavioral and emotional traits. While researchers have known for more than two decades that the culprit behind the disease is an unusual mutation characterized by the excess repetition of a particular segment of the genetic code, they weren't sure why the presence of a large number of these repetitions — 200 or more — sets the disease process in motion.

Using stem cells from donated human embryos that tested positive for fragile X syndrome, the scientists discovered that early on in fetal development, messenger RNA — a template for protein production — begins sticking itself onto the fragile X syndrome gene's DNA. This binding appears to gum up the gene, making it inactive and unable to produce a protein crucial to the transmission of signals between brain cells.

[link to weill.cornell.edu]
 Quoting: Face Palmer


:potatoupsidedown:
Anonymous Coward
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02/28/2014 08:36 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Your topics are always so good!

I wonder if the GMO crap has something to do with this. I mean NO one heard of autism when I was a kid. And that was only 20 years ago or so. Now it's prevalent and normal! That's not right! It's either the GMO food or the aggressive vaccines we're pushing on infants these days.

Something is definitely working against nature here.
 Quoting: calx


The diagnostic criteria for autism has changed greatly over the last 20 years. It includes a lot more people, especially on the higher functioning end of the spectrum. So of course cases will increase because of that.

Way back when, most of what would be autism cases now, woukd have either been diagnosed as mental retardation, or perhaps the child would be labeled "slow" or "strange".
 Quoting: Oubliette


20 years ago, way back when, Sweetheart, some of those people actually out ran the dinosaurs and are still alive to tell you that, in school there was usually one or two kids that were "weird", not 50.
Anonymous Coward
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02/28/2014 08:46 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Yet another cover story for the damage
VACCINES Cause

Want to keep your brain, or not have a special needs
Child or Parent, Don't Vaccinate, and tell your parents if they choose to vaccinate they can NOT count on you to change their diapers and feed them since they chose to destroy their brains.
Anonymous Coward
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02/28/2014 08:55 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
Something is definitely working against nature here.
 Quoting: calx


Yep, rare & almost non existent with in Amish communities!
 Quoting: Watdhel


kitty Mal 2:3 Behold, I will corrupt your seed, and spread dung upon your faces, even the dung of your solemn feasts; and one shall take you away with it.
 Quoting: Judethz


Thank you for your touching personal story...
duFontaine.

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02/28/2014 08:57 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
AUTISM AND ANTI-BIOTICS

Antibiotics DESTROYS the gut flora.

TONS of break through research. [link to www.google.com (secure)]
"Accept now that all you have seen from the day of your birth on the surface of the earth, to the present, are wonderful only because the finite mind of man is confused with fragments of evidence, that, from whatever direction we meet them, spring from an unreachable infinity."

"There was a man who could create what could not be imagined. A temple so great you questioned if it was built with human hands. A man who built an idea into the greatest force the world has ever known. A world built from a single word. I care not for the folly of man but for the end of human contention."
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02/28/2014 09:00 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
AUTISM AND ANTI-BIOTICS

Antibiotics DESTROYS the gut flora.

TONS of break through research. [link to www.google.com (secure)]
 Quoting: duFontaine.


Well, in my previous post that I suggested that they look into vitamin D deficiency which is very common among autism kids. Vitamin D is basically your natural antibiotic. No vitamin D, you get sick more often so you need more synthetic antibiotic...
Nachos

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02/28/2014 09:01 AM
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Re: Scientists Uncover Trigger for Most Common Form of Intellectual Disability and Autism
AUTISM AND ANTI-BIOTICS

Antibiotics DESTROYS the gut flora.

TONS of break through research. [link to www.google.com (secure)]
 Quoting: duFontaine.


autism is usually diagnosed before they even start school...
Anonymous Coward
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02/28/2014 09:04 AM
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AUTISM AND ANTI-BIOTICS

Antibiotics DESTROYS the gut flora.

TONS of break through research. [link to www.google.com (secure)]
 Quoting: duFontaine.


autism is usually diagnosed before they even start school...
 Quoting: Nachos


Most likely, it starts in the womb...





GLP