What if September is about Genetic Modification of Humans? | |
Anonymous Coward User ID: 69604837 United States 07/22/2015 09:09 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 69678570 Netherlands 07/22/2015 09:17 PM Report Abusive Post Report Copyright Violation | DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out NF-κB can also be activated by DNA damage, though relatively less is known about the signal transduction mechanisms that link DNA damage in the nucleus with activation of NF-κB in the cytoplasm. Here, we focus on the conserved signaling pathway that has emerged that promotes NF-κB activation following DNA damage. Post-translational modification of NF-κB essential modulator (NEMO) plays a central role in linking the cellular DNA damage response to NF-κB via the ataxia telangiectasia mutated (ATM) kinase. Accumulating evidence suggests that DNA damage-dependent NF-κB activation may play significant biological roles, particularly during lymphocyte differentiation and progression of human malignancies. [link to www.ncbi.nlm.nih.gov] This invention provides compositions and methods for the selective inhibition of cytokine-mediated NF-κB activation by blocking the interaction of NEMO with IκB kinase-β (IKKβ) at the NEMO binding domain (NBD). [link to www.google.com] Genotoxic stress [link to en.wiktionary.org (secure)] |