Why doesn't nature produce potent dissociation and potent serotonergic agonism simultaneously?

William White once wrote...

"Serotonergics are the 'Ana' side of Chaos, dissociatives the 'Kata' side of Chaos (Chaos being the essential driving energy behind reality, if you will)."

...and my psychonautical journeys of five of the seven most potent natural and man-made seas have led me to believe he came to a profound realization.

Which begs the question that is the title of this thread.

I need to find a way to make a psilocybin variety also produce muscimol or an amanita variety also produce psilocybin. Or maybe Ibogaine or S. Divinorum that also produces psilocybin.

If ever there were a legacy I would give to this place, I think that would be it.


Granted, there are some that could be arguable exceptions, notably Ibogaine and Salvia, being potent kappa-opioid agonists and SSRIs. The serotonergic action is indirect, though, and is decidedly different from direct, potent 5HT agonism.

These being the closest thing to natural psychoactives in the spectrum I'm looking at, though, it makes me wonder what kind of healing potential would be present.

I already have a guinea pig, being myself ofc, but what I really need is someone who can follow everything I'm speaking of and help me understand more than I already do.

I'm not sure which dissociative route would pose the least amount of risk when combined with potent 5HT agonism. Would using GABA agonism, NMDA antagonism, or kappa opioid agonism for potent dissociation come with the lowest risk of serotonin syndrome?

I've looked in the past before, and found it to be so fringe of a speculative experience to embark on that all I have come across is fool-hardy party har-har types having little understanding of what they're messing with and just messing around to mess around, usually with no self-introspection done, sometimes painful psychological experiences that leaves them with either little recall or warning to not do the same thing.