After a reign of 55 years (for 10 of which he was co-regent with his father), the longest in the history of Judah, he died in c. 643 BC and was buried in the garden of Uzza, the "garden of his own house" (2 Kings 21:17–18; 2 Chronicles 33:20), and not in the City of David, among his ancestors.

Manasseh re-instituted polytheistic worship and reversed the religious changes made by his father Hezekiah, for which he is condemned by several Biblical texts.

2 Kings 21:7 New International Version (NIV)

7 He took the carved Asherah pole he had made and put it in the temple, of which the Lord had said to David and to his son Solomon, “In this temple and in Jerusalem, which I have chosen out of all the tribes of Israel, I will put my Name forever.