Ketamine Therapy is the most effective it almost completely relieves depression within 30min. And the anti-depressant effects last around a month from a single moderate dose. They actual have Ketamine Therapy centers now but insurance doesn’t cover it yet so it’s expensive as fuck.

You can get technically legal Analogs of Ketamine, PCP, & PCE though for around only $60 a Gram. All three pretty much have the same effects for depression. I’ve used most of them an can attest to their effectiveness. There’s Deschloroketamine, 2-Fluorodeschloroketamine, 3-MeO-PCP, 3-MeO-PCE, 3-HO-PCP, 3-HO-PCE, and a couple more new ones will be released this year as well...