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Message Subject Covid19/2021-22 OMICRON/ VIRUS "IHU" FRANCE:P13310/NEWEST VIRUS: "NEOCOV" HIGH INFECTION RATE+1 IN 3 DIE !?! P13315
Poster Handle Anonymous Coward
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Prions are very specific mis-folded proteins, which have the ability to cause other copies of the same protein to become mis-folded in the same way. Any old mis-folded protein will not become a prion. The body is chock full of mis-folded proteins - they are removed by your cells and dealt with all the time. Prions are really rare, super weird proteins, and again very specific. Like if a pair of scissors were broken in juuuust the right way to become a tool for turning other scissors into the same kind of broken scissors. Super unlikely and weird.

The next thing to understand is that the degradation of mRNA has nothing to do with the mis-folding of proteins. The cells translation machinery reads the mRNA to determine the order of amino acids to make a protein. If the chain of amino acids folds correctly or not after that has nothing to do with the RNA. The only way a degraded mRNA could change the protein is if the sequence of the mRNA were changed, which doesn't happen during degradation. If we think of the mRNA as like a recipe for a protein written on a piece of paper, degrading the mRNA is like burning the paper, not like scrambling the list of ingredients to produce a new recipe. So just like if I gave you a recipe for apple pie, and you lit it on fire, you wouldn't expect it to turn into a recipe for fried rice - it would just burn up. That's the concern with degrading RNA in vaccines - not that it will turn into something different, but instead that it will just break down into nothing.

To connect these two points, there is no risk that an RNA vaccine would result in prions. This would require two extremely unlikely events to happen: one for the RNA to change into a coding sequence for a different protein, instead of simply being broken down and disappearing. And two, for the sequence that the RNA changed into to be the precise coding sequence of a prion, which is a super rare and weird protein.

To push the cooking metaphor further, this would be like a recipe for apple pie catching on fire, and then instead of burning up, turning into a recipe for an intercontinental ballistic missile. It just wouldn't happen.

RNA vaccine degradation is harmless, it would just make the vaccine not work.
 
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