COVID* STANDFORD MASK STUDY---Elsevier journal to retract widely debunked masks study whose author claimed a Stanford affiliation p345

[link to www.foxnews.com (secure)]

Trump to reveal coronavirus 'breakthrough' therapeutic, WH press secretary says

President Trump plans to hold a news conference Sunday evening regarding a potential major therapeutic “breakthrough” for treating the coronavirus.

The president will announce the development at 6 p.m., accompanied by Health and Human Services Secretary Alex Azar and Dr. Stephen Hahn, head of the Food and Drug Administration, White House press secretary Kayleigh McEnany posted on Twitter late Saturday.

Earlier in the day, the president suggested someone at the FDA was purposefully trying to delay clinical trials for therapeutics and vaccines for political purposes.

“Obviously, they are hoping to delay the answer until after November 3rd,” Trump tweeted, referring to Election Day. “Must focus on speed, and saving lives!”

[link to www.foxnews.com (secure)]

Coronavirus survivors plagued by long-term ailments

[snip]


Lasting effects from COVID-19 including symptoms such as loss of the sense of smell, a dry cough, a flu or fever, shortness of breath, nausea and chronic fatigue, Business Insider reported.

[snip]

As if that weren't enough, the problems patients experience are also more complex and varied, including heart, lung and psychological symptoms.

Additionally, some underlying issues may be "unmasked" by the disease, depending on the severity of the infection, according to Scientific American.

[snip]

While much remains unknown to doctors fighting the disease, coronavirus hallmarks such as lung damage, breathing problems, blood clots, heart inflammation, headaches and other neurological issues and extreme fatigue may help them identify additional treatment options.



This is not a one-and-done illness. You do not want to get this.

This is starting to look like Lyme Disease. Chronic.

[link to www.scientificamerican.com (secure)]

Why Some People Get Terribly Sick from COVID-19

You might have a sniffle and be done. You might run a fever with a cough and unshakable fatigue for five days—or 10. Or you might end up in a hospital, gasping air into congested lungs, an immunological storm raging in your body. And you might not make it through COVID-19 alive.

[snip]

For a given individual, the elements of risk stack up like the layers of a Russian nesting doll. The innermost core includes genes, biological sex and age. Cellular and hormonal factors that accompany these characteristics affect vulnerability to infectious microbes, including SARS-CoV-2, the coronavirus causing the pandemic. The second layer consists of diseases and chronic conditions acquired over time, many of which make it easier for the virus to enter cells or harder for the body to fight it effectively. The outermost layer reflects the accumulated nicks and gouges of external circumstance: housing and work conditions, poor access to health care, nutritional status, and exposure to toxins and pollution. For people of color, these social and economic aspects include the cumulative stresses of systemic racism and discrimination.

[snip]

[link to www.economist.com (secure)]

When covid-19 becomes a chronic illness

THE SYMPTOMS began in March, says Laura, a British woman in her mid-20s. At first covid-19 felt like a bad case of flu: a dry cough, fever, shortness of breath, loss of smell, “horrendous nausea” and general fatigue. After three weeks of rest, things started to improve. Five months later, she has still not recovered. Sometimes her symptoms ease for a week or two



The rest is behind a paywall. Sorry.

[link to www.statnews.com (secure)]

FDA, under pressure from Trump, expected to authorize blood plasma as Covid-19 treatment

President Trump is expected to announce Sunday evening that the Food and Drug Administration will authorize the use of blood plasma from patients who have recovered from Covid-19 as a treatment for the disease, according to an individual familiar with the plans.

The decision, which Trump’s press secretary heralded ahead of time as a “major therapeutic breakthrough,” likely falls far short of that description — and could generate intense controversy inside the administration and the broader scientific community.

Blood plasma is among a host of potential therapeutics that have been undergoing testing in clinical trials. The hope is that infusions of antibody-rich plasma from those who have recovered from Covid-19 can be injected into ill patients, kickstarting their immune system and allowing them to fight off the virus until they can generate their own antibodies.

A study conducted by the Mayo Clinic and the National Institutes of Health found that plasma treatments appeared to have a small but statistically significant impact on reducing mortality in hospitalized Covid-19 patients who received the infusions within three days of the onset of symptoms, compared with those who got plasma later. That study, while large, did not include a placebo group, making it difficult to interpret the data.

Oh, and statistically significant doesn't mean clinically significant.

Prediction - Around 6 o'clock pm tonight OP and his legions of libtard brown nosers are gonna be very butthurt.

Also...OP says.."kids x-mit covid as easily as adults".


There is literally ZERO evidence to support this bogus claim.
Where do you pull this bullshit out of OP?

Can't be your ass, there's no room, cuz you're already completely full of shit.

See you at 6.

This doesn’t seem to be an unreasonable projection. If deaths are currently clocking along at 1,000 per day, that’s 30,000 dead per month. There are approximately 127 days left in the year, or four months and one week.

That’s 127,000 deaths on top of the existing deaths of 180,000, or 307,000 total.

The pandemic has been raging for six months now and we’ll be ten months in by year’s end. By the time a full twelve months have elapsed, America will see a total of 370,000 deaths, or half as many as were seen in the 1957 pandemic that killed 675,000 Americans.

Aww, aren't you precious. I normally ignore or delete dumbassery such as this, mostly because you're too stupid to comprehend most of what is posted. But, in the unlikely event you actually come back to this thread, here is some of the "zero evidence" you believe doesn't exist. It's been posted several times already here, but you are too busy being the Pivot Man in the Trump-Knows-Everything-About-COVID Circle Jerk, I'm sure you missed it.

Here ya go:

[link to www.jpeds.com (secure)]

Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses

Conclusion

This study reveals that children may be a potential source of contagion in the SARS-CoV-2 pandemic in spite of milder disease or lack of symptoms, and immune dysregulation is implicated in severe post-infectious MIS-C.

Epidemiology and Transmission of COVID-19 in Shenzhen China: Analysis of 391 cases and 1,286 of their close contacts

[link to www.medrxiv.org (secure)]
"...children are at similar risk of infection as the general population, though less likely to have severe symptoms; hence should be considered in analyses of transmission and control...."


[link to jamanetwork.com (secure)]

Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19)

July 30, 2020

Our analyses suggest children younger than 5 years with mild to moderate COVID-19 have high amounts of SARS-CoV-2 viral RNA in their nasopharynx compared with older children and adults.



I even posted the important take-away from these studies, since I'm sure you can't be bothered with being proven to be an idiot.

Carry on, Dumbass.

Real sciencey people discussing the science of Trump's big emergency announcement.

[link to www.statnews.com (secure)]

Is convalescent plasma safe and effective? We answer the major questions about the Covid-19 treatment

The Food and Drug Administration on Sunday issued an emergency authorization for doctors to treat Covid-19 using blood plasma from patients who’ve recovered from the disease.

Below, STAT answers the major questions surrounding convalescent plasma as a Covid-19 treatment and the science supporting its use.

[snip]

A study released Aug. 13 — but not yet peer-reviewed — suggested that using convalescent plasma to treat patients with severe Covid-19 soon after their diagnosis was associated with a lower likelihood of death. But the study had serious scientific limitations that make interpreting the findings difficult.

The Mayo Clinic study, which enrolled more than 35,000 patients, showed that patients who received transfusions within three days of their Covid-19 diagnosis had a seven-day death rate of 8.7%, while patients who received plasma treatment after four or more days had a mortality rate of 11.9%. The difference met the standard for statistical significance.

The study didn’t include a placebo group for comparison, however, so it’s unclear exactly how impactful the plasma treatment might be. The study was sponsored by the National Institutes of Health and sought to broaden access to convalescent plasma, part of a so-called “expanded access” program not designed to definitively test how well the treatment works, but instead to quickly get it to patients.

More rigorous randomized, placebo-controlled studies of convalescent plasma are ongoing.


Comment: As I said before, statistical significance does not necessarily mean clinical significance.



***********************************

[link to twitter.com (secure)]

Eric Topol
@EricTopol
Today's "breakthrough" announcement is unlikely to be any breakthrough.
1. Convalescent plasma has no randomized trials. It contains many antibodies that have no neutralizing effect. If it has efficacy, it will be be relatively modest, at best.

Eric Topol
@EricTopol
·
5h
Replying to
@EricTopol
2. There are no new, large-scale randomized trials that have been completed with repurposed drugs; the combination of JAK inhibitor (Baricitinib) and Remdesivir may have results but it only has 400 patients and no replication

Eric Topol
@EricTopol
·
5h
3. Type 1 interferon (intranasal) early, preventive therapy has considerable promise (reviewed w/ @VirusesImmunity
and this
Thread
; there are many trials but they are in progress

Eric Topol
@EricTopol
·
5h
4. True breakthroughs in medicine are exceedingly rare.
It is even more rare—actually unprecedented—for they to be announced by a politician, no less a @POTUS

In the context of other magic and cures that have similarly been proclaimed in recent months, this all aligns well.



Eric Topol
@EricTopol
·
3h
5. It's even worse than this. There is no breakthrough and the @US_FDA
commissioner @SteveFDA
has caved to Trump's pressure (including yesterday's tweet) to promote it as if there was one.



Eric Topol
@EricTopol
·
34m
Outrageous to listen to @realDonaldTrump
@secAzar
@SteveFDA
claiming a 35% improved survival in an observational preprint study compared w/ late-treated patients. There's no evidence to support any survival benefit. 2 days ago FDA's website stated there was no evidence for an EUA

************************************************


[link to twitter.com (secure)]

Jeremy Faust MD MS (ER doc, policy
Nerd face
)
@jeremyfaust
This 35% reduction in deaths number....

Comes from a NON-PEER REVIEWED STUDY from June.

We have an FDA emergency use authorization based on a study that has not even been accepted by a medical journal.

If it was REMOTELY good, that study would be in a medical journal already.



***********************************


Well, you get the idea. Listen to scientists not politicians.

[link to www.japantimes.co.jp (secure)]

Hong Kong reports first coronavirus reinfection

Hong Kong – A man was infected with the coronavirus after recovering from an initial bout in April in what scientists said was the first case showing that reinfection may occur within a few months.

The 33-year-old’s second SARS-CoV-2 infection was detected via airport screening on his return to Hong Kong from Europe this month. Researchers at the University of Hong Kong used genomic sequence analysis to prove that he had been infected by two different strains. The information technology worker didn’t develop any symptoms from his second infection, which might indicate any “subsequent infections may be milder,” the researchers said.

“Our findings suggest that SARS-CoV-2 may persist in humans,” Kwok-Yung Yuen and colleagues said Monday in a paper accepted for publication in the journal Clinical Infectious Diseases. The findings are reminiscent of the coronaviruses that cause the common cold, and suggest SARS-CoV-2 may continue to circulate “even if patients have acquired immunity via natural infection or via vaccination,” they said.




We, of course, knew that reinfection was possible, anecdotally. But, now we have proof.

[link to www.wsj.com (secure)]

As Child Covid Cases Rise, Doctors Watch for Potential Long-Term Effects

As more children become infected with Covid-19, doctors are paying closer attention to potential long-term effects.

In adults, one of Covid’s most troubling effects has been so-called long-haul cases, in which people whose illness initially seemed moderate end up having symptoms for months, sometimes getting worse over time. Now as doctors warn that children may be more vulnerable to the virus than initially believed, researchers are looking more closely at longer-term symptoms in kids, too.

Children now represent about 9% of all Covid-19 cases in the U.S., up from 2% in March, according to the most recent weekly report issued from Children’s Hospital Association and the American Academy of Pediatrics. The number of child Covid-19 cases has doubled since July 9, totaling 406,109 as of Aug. 13, according to cases reported from 49 states.

The majority of children experience mild illness or even no symptoms from Covid-19, doctors say. But some are reporting symptoms that persist for weeks, or the development of post-viral syndromes. Symptoms reported include fever, cough, headaches, shortness of breath and gastrointestinal problems.

[link to apnews.com (secure)]

As world grapples with pandemic, schools are the epicenter

[link to twitter.com (secure)]

Eric Feigl-Ding
@DrEricDing
Round pushpin
IMPORTANT Starbucks outbreak in South Korea
Flag of South Korea
reveals a lot: A #COVID19 infected 30 year old visited Starbucks for 2 hours
Rightwards arrow
then infected 56 others who visited. Likely related to 6 recirculating air conditioners. 2nd Floor hotspot. Suggests aerosols

[link to translate.google.com (secure)]

I can't copy-n-paste for some reason. This is an article about the Starbucks, translated from Korean.

Eric Feigl-Ding
@DrEricDing
2) another article states 5 AC units and 2.5 hours: “was sitting right in front of one of the five air conditioners installed on the ceiling of the second floor of the store, and had a conversation with an acquaintance for about 2 hours and 30 minutes.”

[link to twitter.com (secure)]

Eric Feigl-Ding
@DrEricDing
3) The other report states 27 people who visited the Starbucks branch visited were first confirmed. The 54 includes secondary and tertiary infections. “As of August 18th, at least 54 people have been confirmed to have been associated with secondary and tertiary infections.”

[link to twitter.com (secure)]

Eric Feigl-Ding
@DrEricDing
4) “The quarantine authorities believe that the aerosol (air containing fine saliva) discharged while A was talking at a seat near the stairs in the corner of the store on the second floor was spread throughout the store by the air conditioner wind.”

[link to twitter.com (secure)]

Eric Feigl-Ding
@DrEricDing
5) “It has been confirmed that all of the primary infections identified so far have stayed at the second floor store at this time. Among the confirmed cases, there were also elementary school students who were in a store on the first floor and used the toilet on the second floor”

[link to twitter.com (secure)]

Eric Feigl-Ding
@DrEricDing
·
Aug 23
6) “so the quarantine authorities believe that a very strong virus was spread quickly through the wind of an air conditioner. there are voices of concern that the use of air conditioners has increased due to the end of the long rainy season and the heat wave has come in earnest”

Eric Feigl-Ding
@DrEricDing
·
Aug 23
7) “and that ventilation is difficult in some facilities, making it difficult to comply with these guidelines. In addition, it is pointed out that even if there is a guideline, a strong recommendation from govt should be accompanied as it is a matter for companies to cooperate.”

Eric Feigl-Ding
@DrEricDing
·
Aug 23
8) “Regarding the case of group infection at Starbucks Paju on the 17th, Jung (Korean CDC official) also said, "(Guests) did not wear masks, and the air conditioner was operated, but the ventilation was not adequate due to humid weather."

Eric Feigl-Ding
@DrEricDing
·
Aug 23
9) “Even if it is not, it is possible to propagate droplets of 2m or more in a closed space, and it is possible to propagate through hand contact and other public facilities. ***Taking off a mask in an indoor space is all dangerous behavior***, and please minimize those parts."

Impossible as they all wear masks.

[link to twitter.com (secure)]

Helen Branswell
@HelenBranswell
Latest vaccine development update from @WHO
has 31 #Covid19 vaccines in human trials, including 6 in Phase 3 (the final phase, designed to prove if a vaccine works). A 7th will start Phase 3 soon.
This is a revolution in outbreak vaccine development.

Continue reading. Masks were NOT worn.

[link to twitter.com (secure)]

BNO Newsroom
@BNODesk
2 cases of COVID-19 re-infection have been confirmed in Belgium and the Netherlands. This follows the first ever confirmed case of re-infection in Hong Kong

Lol. You're right, somebody is lying. I wonder who.

“The first is that it suggests that previous infection is not protective,” he said. “The second is that it raises the possibility that vaccinations may not provide the hope that we have been waiting for.”

Eric Feigl-Ding
@DrEricDing
·
Aug 23
8) “Regarding the case of group infection at Starbucks Paju on the 17th, Jung (Korean CDC official) also said, "(Guests) did not wear masks, and the air conditioner was operated, but the ventilation was not adequate due to humid weather."

[link to www.bostonglobe.com (secure)]

Biogen conference likely led to 20,000 COVID-19 cases in Boston area, researchers say

A new study shows the Biogen conference held at Boston’s Marriott Long Wharf hotel in February played a far greater role in spreading the coronavirus than previously thought.

[link to apnews.com (secure)]

FDA chief apologizes for overstating plasma effect on virus

Responding to an outcry from medical experts, Food and Drug Administration Commissioner Stephen Hahn on Tuesday apologized for overstating the life-saving benefits of treating COVID-19 patients with convalescent plasma.

Scientists and medical experts have been pushing back against the claims about the treatment since President Donald Trump’s announcement on Sunday that the FDA had decided to issue emergency authorization for convalescent plasma, taken from patients who have recovered from the coronavirus and rich in disease-fighting antibodies.

[snip]

Hahn had echoed Trump in saying that 35 more people out of 100 would survive the coronavirus if they were treated with the plasma. That claim vastly overstated preliminary findings of Mayo Clinic observations.

So I don’t lose the thread post

Grandson got quarantined, He got exposed at school, he is fine. He refused to get tested age 17 and was pissed he couldn't go to work or school.
They didn’t close the school not even to clean it.
They didn’t quarantine my daughter or ex son in law., grandson spends time at both homes.