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REPORT COPYRIGHT VIOLATION IN REPLY
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Message Subject
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Coronavirus Intel Clearinghouse
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Poster Handle
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Anonymous Coward |
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Post Content
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Hello 011, from another thread:
The wuhan virus is identical to the ACE2 key-- and it fits into the keyhole.
So-- flooding the body with ACE2 would be a means of sopping up the virus-- NOT inhibiting ACE2.
What's your take on that.. some suggested ACE2 inhibitors, but this person thinks it could make matters worse.
Quoting: Anonymous Coward 78455686 Hello, friend. See my post directly above yours. This ACE2 issue is contradictory. Will be interesting to see OP’s reply. . It's not contradictory. There are two ways to inhibit a receptor site: Competitively, and antagonistically 1) Competitively: flooding the receptor with other ligands that outnumber the target. By introducing ACE2 agonists (activators) the virus has to compete for open ACE2 receptors 2) Antagonistically: ACE2 antagonists bind with ACE2 receptors and disable their functionality. This can happen at the normal binding site, or at binding sites that do not compete with agonists, but stop the receptor from functioning regardless of if there is an agonist present. Both methods can be used simultaneously to greater effect than individually. Using too many antagonists could cause loss of functionality of the ACE2 receptor, which could have bad effects. Using too many competitive agonists could cause excessive ACE2 signalling and eventual ACE2 downregulation, which could have bad effects. Using a blend of the two will have the best ratio of blocking the virus with minimal bad effects. OP, that’s an excellent explanation, thank you! Now though.... dosages. I realize you can’t recommend a dosage without running afoul with the law, so let’s phrase it this way: If YOU were a 200-pound male that wanted to protect yourself against the 2019NCoV, how many mg of an ACE2 agonist and inhibitor would YOU take, how frequently, and over what period? ....and what would those numbers be if you were a 130-pound woman? BTW, considering your posts may likely be saving actual lives in the near future, I cannot express my gratitude for your time and knowledge. Please disregard the trolls. THANK YOU. . OP, you may as well disregard my question above. It seems any form of ACE2 agonist/antagonist/inhibitor is by prescription only. Any suggestions on OTC or natural alternatives to achieve approximately similar results to ACE2 meds? .
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