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Message Subject Coronavirus Intel Clearinghouse
Poster Handle Anonymous Coward
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Okay, so returning to natural alternatives to ACE2 agonist/blocker options...

I pulled this nice little layman’s explanation of the NCoV ACE2 entry point from another related thread:



From that same thread:


What you are looking for is to block that ACE2-facilitated infection of your cells by blocking the ACE2. There are different ways to do that.
Scientists have been looking for molecules that can block the ACE2, and they found various ways...

As you do not want to wait until you are admitted to the hospital and then try to persuade the doctors to follow an alternative way of treating you, the only option is to find a natural way to do it yourself.

So, here are your natural options, approved by scientists:


In this study, we summarize several active compounds including baicalin, Scutellarin, Hesperetin, Nicotianamine and Glycyrrhizin that could have potential anti-2019-nCov effects, and we conduct molecular docking to predict their capacity for binding ACE2, subsequently preventing the 2019-nCov infection. „
[link to www.preprints.org (secure)]

Abstract:
„The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that Glycyrrhizin should be assessed for treatment of SARS.“
[link to www.ncbi.nlm.nih.gov (secure)]


.....
Soooooo....... off I went hunting for more info on Glycyrrhizin. I learned too much can be detrimental, but the approved dosing is 250-500mg up to 3 times per day, standardized to contain 20% glycyrrhizinic acid.

I was able to find a 450mg 25% Glycyrrhizin extract online for just $14.

So that should help on the ACE2 blocker side, it needs to be counterbalanced with an ACE2 agonist, yes?

If so, I need to find a natural agonist alternative now....

Your thoughts, OP?
.
 
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