Possible interaction between Toxoplasma and Covid?... significant if true. | |
Anonymous Coward User ID: 12811444 United States 03/03/2020 09:08 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 12811444 United States 03/03/2020 09:11 AM Report Abusive Post Report Copyright Violation | |
Comperio
(OP) User ID: 76246961 Denmark 03/03/2020 09:14 AM Report Abusive Post Report Copyright Violation | There has to be a binary component that makes it more deadly in some cases. This could be it. Quoting: Anonymous Coward 12811444 Yes - there is some other agent(s) in play. "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Anonymous Coward User ID: 78380485 Netherlands 03/03/2020 09:27 AM Report Abusive Post Report Copyright Violation | |
Comperio
(OP) User ID: 76246961 Denmark 03/03/2020 10:06 AM Report Abusive Post Report Copyright Violation | Incubation time for Toxoplasmosis is 10 to 20 days. "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 75890248 Denmark 03/03/2020 04:55 PM Report Abusive Post Report Copyright Violation | In all Covid cases with pneumonia, there are ground-glass opacities in the lungs. In all Toxoplasmosis cases with pneumonia, there are ground-glass opacities in the lungs. Toxoplasma cysts are present in the lungs - and the longer the infection the more cysts. Last Edited by Comperio on 03/03/2020 05:47 PM "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 75890248 Denmark 03/03/2020 05:47 PM Report Abusive Post Report Copyright Violation | In a Covid cohort, leukocytosis was detected in 1/3 of the patients and lymphocytosis in 2/3 of patients. One of the laboratory hallmarks of toxoplasmosis is lymphocytosis and the presence of atypical lymphocytes Both leukopenia and leukocytosis may be observed in clinical toxoplasmosis "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 75890248 Denmark 03/03/2020 05:57 PM Report Abusive Post Report Copyright Violation | Adult Respiratory Distress Syndrome (ARDS) is associated with disseminated toxoplasmosis. ARDS is one of the most severe effects of Covid. "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Anonymous Coward User ID: 78432514 United States 03/03/2020 07:22 PM Report Abusive Post Report Copyright Violation | So, you think they are lying about the disease origin? That’s a parasitic..so a little dewormer ought to do the trick? But seriously, wouldn’t toxoplasma be difficult to transmit? It’s from infected cats. I mean Chinese do eat cats, but do you think it could become aerosolized? |
Comperio
(OP) User ID: 77095264 Denmark 03/04/2020 03:53 AM Report Abusive Post Report Copyright Violation | So, you think they are lying about the disease origin? That’s a parasitic..so a little dewormer ought to do the trick? But seriously, wouldn’t toxoplasma be difficult to transmit? It’s from infected cats. I mean Chinese do eat cats, but do you think it could become aerosolized? Quoting: Anonymous Coward 78432514 No - Covid is Covid, no matter the origin. What I am arguing is that there could be significant comorbidity with possible activation of Toxoplasma. Toxoplasma is present in half of the adult population and even more if you are +70 years old. There are several pathways for how Covid could be activating Toxoplasma, thus developing Toxoplasmosis in the infected individual. "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Anonymous Coward User ID: 76381585 United States 03/04/2020 04:08 AM Report Abusive Post Report Copyright Violation | I was thinking of that the other day. It's possible In people whose immune defenses are weakened dormant toxoplasmosis can reactivate and cause a severe brain infection (encephalitis), which can lead to seizures and other neurological problems. If toxoplasmosis affects the lungs, there can be shortness of breath, fever, a dry cough, coughing up of blood and, eventually, respiratory failure. [link to www.health.harvard.edu (secure)] |
Comperio
(OP) User ID: 77095264 Denmark 03/04/2020 04:16 AM Report Abusive Post Report Copyright Violation | I was thinking of that the other day. It's possible Quoting: Anonymous Coward 76381585 In people whose immune defenses are weakened dormant toxoplasmosis can reactivate and cause a severe brain infection (encephalitis), which can lead to seizures and other neurological problems. If toxoplasmosis affects the lungs, there can be shortness of breath, fever, a dry cough, coughing up of blood and, eventually, respiratory failure. [link to www.health.harvard.edu (secure)] Spot on. If one looks at the data on the severity of Covid, it certainly reflects the distribution of Toxoplasma in the population.....and so does the reported symptoms. "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Anonymous Coward User ID: 76341916 United States 03/04/2020 04:56 AM Report Abusive Post Report Copyright Violation | |
Comperio
(OP) User ID: 77095264 Denmark 03/04/2020 09:06 AM Report Abusive Post Report Copyright Violation | "Compared with non-severe patients with COVID-19, severe patients commonly had neurologic symptoms manifested as acute cerebrovascular diseases, consciousness impairment and skeletal muscle symptoms." "Patients with cerebral toxoplasmosis mimicking an acute cerebrovascular accident or a brain tumor are particularly frequent." "The patients (with Toxoplasmosis) had marked lymphopenia, fever, diffuse encephalitis, pneumonia, pancytopenia, and myopathy. Muscle involvement; included weakness and wasting, myalgias"...i.e skeletal muscle symptoms. "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 77095264 Denmark 03/04/2020 09:40 AM Report Abusive Post Report Copyright Violation | This corresponds very well with the effects of Toxoplasma infection, as this has to have spread in the body over a number of years for an acute Toxoplasmosis to develop serious symptoms. Last Edited by Comperio on 03/04/2020 09:40 AM "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 77095264 Denmark 03/04/2020 10:44 AM Report Abusive Post Report Copyright Violation | Primary or acute infection of Toxoplasma in immunocompetent patients can be asymptomatic or result in the following clinical manifestations, alone or in combination: I have added a Covod notification where Covid is presented with the same symptoms... • Chorioretinitis • Lymphadenopathy (Covid) • Fever (Covid) • Headache (Covid) • Myalgias, i.e muscle pain (Covid) • Arthralgias, i.e joint pain (Covid) • Sore throat (Covid) • Stiff neck • Nausea (Covid) • Abdominal pain (Covid) • Diarrhea (Covid) • Anorexia • Rash • Confusion (Covid) • Earache • Eye pain • General malaise and/or fatigue (Covid) • Unexplained hepatitis • Myositis, and/or myocarditis (Covid) • Community-acquired pneumonia (Covid…big time) • Death in immunocompetent patients (Covid) Toxoplasmic pneumonia has been classically associated with bilateral interstitial pulmonary infiltrates “Histological examination showed bilateral diffuse alveolar damage (...) Interstitial mononuclear inflammatory infiltrates” (Covid) “Interstitial mononuclear inflammatory infiltrates, dominated by lymphocytes, were seen in both lungs” (Covid) "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Formally CannabisUser1111111 User ID: 75555655 United Kingdom 03/04/2020 01:51 PM Report Abusive Post Report Copyright Violation | wiki less than 50% Infection usually occurs by eating undercooked contaminated meat, exposure from infected cat feces, or mother-to-child transmission during pregnancy. How many of us play with cat poop, thats a no then. People are know to undercook food hence food poisoning and mothers have children quite often. Take yer pic OP. |
Comperio
(OP) User ID: 76246961 Denmark 03/04/2020 02:21 PM Report Abusive Post Report Copyright Violation | wiki less than 50% Quoting: Formally CannabisUser1111111 75555655 Infection usually occurs by eating undercooked contaminated meat, exposure from infected cat feces, or mother-to-child transmission during pregnancy. How many of us play with cat poop, thats a no then. People are know to undercook food hence food poisoning and mothers have children quite often. Take yer pic OP. If you want a solid overview of Toxoplasma, look here: [link to medium.com (secure)] "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 75890248 Denmark 03/05/2020 10:49 AM Report Abusive Post Report Copyright Violation | A hallmark of Toxoplasma is its relation to Schizophrenia.... [link to www.chinaxiv.org] Quoting: JADR+ We noticed an unusual increase of first-time patients with schizophrenia (F20) in January 2020 since the outbreak of COVID-19. The aim of this retrospective study is to validate this observation and find potential risk factors, if applicable. A total number of 13,783 records from outpatients in January 2020 were investigated thoroughly. Comparisons between incidence of schizophrenia in outpatients in January 2020 and similar periods of 2017-2019 were made to minimize seasonal influence. Relationship of incidence of schizophrenia and COVID-19 infections in China was calculated. Limited personal information (age, gender, approximate residence) was analyzed to find risk factors.After excluding seasonal factors such as Spring festival, a positive relationship between incidence of schizophrenia in first-time patients and countrywide epidemic situation was found. Statistical results further showed a significant increase of median age from 39 to 50 for first-time patients diagnosed with schizophrenia which is unusual. Meanwhile, a slight but not significant change was found in distribution of gender and approximate residence (urban/suburb). Our data supported that COVID-19 outbreak increased risk of schizophrenia in aged adults which is consistent with the fact that COVID-19 is more lethal to elders. We strongly appeal that public healthcare in countries either with or without infected patients should prepare in advance for potential risks in public mental health. "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 75890248 Denmark 03/05/2020 10:52 AM Report Abusive Post Report Copyright Violation | "Lopinavir/ritonavir caused parasitological improvement in acute toxoplasmosis. Both forms prevented the egress of the tachyzoites. They led to apoptosis and autophagy of the tachyzoites. They led to disruption of the parasitophorous vacuole and the nanotubular network." [link to www.sciencedirect.com (secure)] "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 78095408 Denmark 03/06/2020 05:32 PM Report Abusive Post Report Copyright Violation | The greatest achievement of Toxoplasma is it's ability to influence the fear/curiosity duality.... "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 78095408 Denmark 03/06/2020 05:39 PM Report Abusive Post Report Copyright Violation | Compressed version. Consider this: Quoting: Comperio Billions of adults all over the world have a so-called “latent infection”. In China and the West, this infection is present in some 25% of the population. Over time, the infection spreads to the brain, heart, lungs and muscle tissue in the form of cysts – so the longer a person has had the infection, the more it will have spread throughout the body. It is estimated that the infection rate – as a rule of thumb – follows your age, i.e if you are 20 years old the probability of being infected is 20%, if you are 70 years old the probability is 70%. The distribution of the infection in the body is orders of magnitude larger in a 70-year-old than in a 20-year-old. IF the immune system is challenged – this infection can go from “latent” to “acute”, and it will show the following symptoms: • Dry cough • Fever • Headache • Flu-like symptoms If it develops further it will have some of the following symptoms: • Pneumonia and Acute Respiratory Distress • Seizures • Cardiac arrest ...and various central nervous system (CNS) disturbances. These symptoms are almost identical to those ascribed to Covid-19. The infection in question is called Toxoplasma gondii which is a single-celled parasite. If/when it becomes a disease, it is called Toxoplasmosis. Toxoplasmosis has an incubation time of 14-20 days. Covid patients have been successfully treated with Lopinavir/ritonavir...that (also) destroys Toxoplasma. Perhaps the virus somehow triggers Toxoplasmosis? Toxoplasmosis can be treated and 100% cured once the diagnosis is made. "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 75006858 Denmark 03/09/2020 04:56 PM Report Abusive Post Report Copyright Violation | Vitamin D3 is said to protect against covid...and toxoplasma: "Regarding the results of this study, the difference in prevalence of T. gondii infection in two groups of vitamin D sufficient and deficient individuals was noticeable and Toxoplasma infection was associated with vitamin D deficiency." "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 75890248 Denmark 03/10/2020 04:57 PM Report Abusive Post Report Copyright Violation | Acute toxoplasmosis has also been reported to show similar symptoms. Central Nervous System (CNS) infections [link to www.xinhuanet.com] Acute Myocardial Injury [link to www.medrxiv.org (secure)] Kidney problems [link to www.medrxiv.org (secure)] "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Comperio
(OP) User ID: 75890248 Denmark 03/15/2020 02:38 PM Report Abusive Post Report Copyright Violation | Covid: Sepsis Toxoplasma: “Collectively, these data demonstrated that chronic infection with T. gondii is a critical factor for sepsis..” Covid: Respiratory Failure Toxoplasma: “Diffuse lung injury may result as a complication of disseminated toxoplasmosis” Covid: Acute Cardiac Injury Toxoplasma: “..myocarditis linked to a recent toxoplasmosis infection is reported, with consistent MR-scan images. Clinically significant heart injury may be a rare, but life-threatening, manifestation of toxoplasmosis” “Cardiac toxoplasmosis was common in this necropsy series..” Covid: Acute Kidney Injury Toxoplasma: “The above examples clearly illustrate the close association between toxoplasmosis and renal function.." Covid: Hypoproteinemia Toxoplasma: “Biochemical abnormalities during the acute phase of (Tg) illness include hypoproteinemia and hypoalbuminemia.” "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Anonymous Coward User ID: 78419874 Canada 03/15/2020 02:51 PM Report Abusive Post Report Copyright Violation | |
Comperio
(OP) User ID: 77095264 Denmark 04/06/2020 07:33 AM Report Abusive Post Report Copyright Violation | Oxygen deprivation is a hallmark of Acute Toxoplasmosis. Dr. Sidell, M. D., is an Emergency-Reponse & Critical Care doctor who has treated COVID-19 infected patients in an intensive care unit at New York City for 9 days and says what they are dying of is not what we think: Quoting: Anonymous Coward 78719721 "The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity. Condemnation without investigation is the height of ignorance." Albert Einstein |
Anonymous Coward User ID: 76519107 Australia 04/06/2020 07:54 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 77202143 Canada 04/06/2020 07:59 AM Report Abusive Post Report Copyright Violation | Covid mortality is extremely low in the younger population (less than 0,5%) and starts growing exponentially from some 40 years of age. Quoting: Comperio This corresponds very well with the effects of Toxoplasma infection, as this has to have spread in the body over a number of years for an acute Toxoplasmosis to develop serious symptoms. By the way, how about several CV19 cases with cats and a tiger? Not dogs. |
Anonymous Coward User ID: 78418541 United States 04/06/2020 08:05 AM Report Abusive Post Report Copyright Violation | So, you think they are lying about the disease origin? That’s a parasitic..so a little dewormer ought to do the trick? But seriously, wouldn’t toxoplasma be difficult to transmit? It’s from infected cats. I mean Chinese do eat cats, but do you think it could become aerosolized? Quoting: Anonymous Coward 78432514 Intersting is pregnant AND hiv people are at major risk. Did they study the hiv part of this virus anymore? |