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Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!

 
Anonymous Coward
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04/13/2020 07:37 PM
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Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
[link to nypost.com (secure)]

Researchers called off a small Brazilian study on the anti-malaria drug chloroquine’s ability to combat coronavirus after some participants experienced potentially fatal heart complications.

The study, which was funded by the Brazilian state of Amazonas, administered the drug to 81 hospitalized patients in Manaus to determine its effectiveness battling coronavirus, according to a report on pre-publication server medRix.

But researchers said they were forced to halt the study early after “potential safety hazards” became apparent.

“Preliminary findings suggest that the higher [chloroquine] dosage (10-day regimen) should not be recommended for COVID-19 treatment because of its potential safety hazards,” researchers wrote. “Such results forced us to prematurely halt patient recruitment to this arm.”

Roughly half of the patients in the study took a 50-milligram dose of chloroquine twice daily for five days, the report said. The other participants were given a single, 600-milligram dose daily for 10 days.


But within three days, some of the patients taking the higher dose experienced arrhythmia, or irregular heartbeats, the report said. By the sixth day, 11 patients had died.
Anonymous Coward
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
Anonymous Coward
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04/13/2020 07:41 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
Considering Brazil is full of a bunch of half-wit idiots it isn't surprising they did something stupid again.
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04/13/2020 07:43 PM

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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


hesright technically Hydroxychloroquine...

Last Edited by Carbonous on 04/13/2020 10:08 PM
Anonymous Coward (OP)
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04/13/2020 07:46 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
Pilgrim001

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04/13/2020 07:47 PM

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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


This. Hydroxychloroquine.
I don't have the time or the crayons to explain this to you.



Slake Blake
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04/13/2020 07:48 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
Wait. So they gave people a dose that was 12 times higher, and then found they were adverse reactions? What sort of news is this? Nonsense. Give somebody 12 times higher dose of almost anything and there will be… Wait for it… Adverse reactions.
Pilgrim001

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04/13/2020 07:50 PM

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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936


Next Brazilians are going to be using fish tank cleaner.

Hydroxychloroquine is NOT the same drug as Chloroquine. They may be cousins or something, but they are NOT interchangeable and NOT the same drug.
I don't have the time or the crayons to explain this to you.



Slake Blake
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04/13/2020 07:52 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


I really doubt that Brazilian doctors are mixing up the correct drugs.
Anonymous Coward (OP)
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04/13/2020 07:53 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
Pilgrim001

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04/13/2020 07:59 PM

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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


I really doubt that Brazilian doctors are mixing up the correct drugs.
 Quoting: Anonymous Coward 78208056


American doctors don't get it right either. It is supposed to be Hydroxychloroquine + z-pack + zink supplement. giving the patient hydroxy alone is not the complete dose. They also need to start giving the medicine as soon as they have symptoms, not when they're bad enough to need a ventilator.
Most hospitals send the person home if they aren't bad enough to admit, but they don't rx hydroxychloroquine for home use.
I don't have the time or the crayons to explain this to you.



Slake Blake
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04/13/2020 08:00 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
They are not the same drug

[link to www.medicinenet.com (secure)]
Anonymous Coward
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04/13/2020 08:03 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936


Are you suggesting the chemical composition for chloroquine and hydroxychloroquine is identical?

They wouldn't call it hydrxychloroquine of the molecule was exactly the same as chloroquine, silly.

It's a different drug. A similar, but very different drug.
Pilgrim001

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04/13/2020 08:04 PM

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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936


This NYPOST hit-piece headlines this with chloroquine and then shows packages of hydroxychloroquine. They need to get their shit straight.
I don't have the time or the crayons to explain this to you.



Slake Blake
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04/13/2020 08:05 PM

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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936


Are you suggesting the chemical composition for chloroquine and hydroxychloroquine is identical?

They wouldn't call it hydrxychloroquine of the molecule was exactly the same as chloroquine, silly.

It's a different drug. A similar, but very different drug.
 Quoting: Anonymous Coward 78134924



ie. you can drink H2O, but you shouldn't drink H2O2. They aren't the same thing.
I don't have the time or the crayons to explain this to you.



Slake Blake
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04/13/2020 08:08 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936


This NYPOST hit-piece headlines this with chloroquine and then shows packages of hydroxychloroquine. They need to get their shit straight.
 Quoting: Pilgrim001


it's the generic version


it's like Sildenafil begin the generic version of Viagra
Anonymous Coward
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04/13/2020 08:09 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936







Hydroxychloroquine = C18H26ClN3O
Chloroquine = C18H26ClN3

Anonymous Coward
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04/13/2020 08:09 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


hesright
 Quoting: Carbonus


ALSO, I’ve looked at the other studies, and NOBODY else used that high a dose for that length of time. The maximum was 800mg (divided in 2 doses) on the first day only, and then 200mg twice/day for another 5 days.
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04/13/2020 08:10 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936







Hydroxychloroquine = C18H26ClN3O
Chloroquine = C18H26ClN3


 Quoting: Anonymous Coward 78791928


There’s a well documented difference in potency and side effects.
Anonymous Coward (OP)
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04/13/2020 08:10 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936


This NYPOST hit-piece headlines this with chloroquine and then shows packages of hydroxychloroquine. They need to get their shit straight.
 Quoting: Pilgrim001


it's the generic version


it's like Sildenafil begin the generic version of Viagra
Anonymous Coward
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04/13/2020 08:11 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936


This NYPOST hit-piece headlines this with chloroquine and then shows packages of hydroxychloroquine. They need to get their shit straight.
 Quoting: Pilgrim001


it's the generic version


it's like Sildenafil begin the generic version of Viagra
 Quoting: Anonymous Coward 69562936




You better tell the doctors.







Hydroxychloroquine = C18H26ClN3O
[link to pubchem.ncbi.nlm.nih.gov (secure)]

Chloroquine = C18H26ClN3
[link to pubchem.ncbi.nlm.nih.gov (secure)]

Anonymous Coward
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04/13/2020 08:12 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
Hydroxychloroquine
Molecular Weight:
335.9 g/mol
[link to pubchem.ncbi.nlm.nih.gov (secure)]


Chloroquine
Molecular Weight:
319.9 g/mol
[link to pubchem.ncbi.nlm.nih.gov (secure)]
Anonymous Coward
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
I'm Sure it was deliberate in hospitals where poor people go.
Anonymous Coward
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04/13/2020 08:12 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
Nobody should even be allowed to comment on this before they’ve read this whole thing: [link to docs.google.com (secure)]
Pilgrim001

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04/13/2020 08:13 PM

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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936


I'm a retired guy on the internet and most of the people on this website know the difference between chloroquine and Hydroxychloroquine, like I do. Brazilian doctors have no fucking excuse for screwing it up. Things change by the day and doctors are supposed to keep up. We do. Trump mentioned both hydroxychloroquine AND chloroquine at first, but then he went to hydroxychloroquine. HCQ is what he order 29,000,000 doses of from india.
I don't have the time or the crayons to explain this to you.



Slake Blake
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04/13/2020 08:16 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
Brazil is in the Malaria capital of the world. FFS does anyone believe this bullshit? Really?

They have been taking this shit for decades.

They either gave the patients the wrong drug or are just flat out lying.

I took that crap for 1.5 years while in Central & South America back in 89-90.

I have no idea what dosage it was (quinine is what we called it) but we took 2 pills in the morning and 2 in the evening.

Thousands of soldiers took it every day. I don't believe this bullshit for a second!
Light travels faster than sound. This is why some people appear bright until you hear them speak
Anonymous Coward
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04/13/2020 08:17 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
That's because chloroquine isnt the drug they're supposed to use.



hydrocychloroquine is.
 Quoting: Anonymous Coward 78134924


its the same drug don't try to spin it.


 Quoting: Anonymous Coward 69562936




Look at the 3D Conformer.

Hydroxychloroquine
[link to pubchem.ncbi.nlm.nih.gov (secure)]

Chloroquine
[link to pubchem.ncbi.nlm.nih.gov (secure)]
Anonymous Coward
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04/13/2020 08:18 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
Looks like this is the one you’re talking about, OP. Read the study and understand methodology instead of taking some journalist’s word at face value.

“ Randomized, double blind clinical trial of 81 patients in Brazil comparing different dosages of chloroquine (1200 mg daily vs 450 mg daily) in the treatment of COVID-19. Study found increased incidence of prolonged QT and a trend toward lethality in the high dose treatment arm. Total fatality rate in the cohort was 13.5%. Of note, patients over age 75 were only enrolled in the high dose treatment arm (12.2% of patients in high dose arm), and the age of the high dose arm was significantly higher than the low dose treatment arm (p=0.02). Lastly, this was a fairly sick cohort of patients at baseline with 43.2% of patients in the ICU and 88.9% on some form of respiratory therapy prior to treatment.”

[link to www.medrxiv.org (secure)]
Anonymous Coward
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04/13/2020 08:22 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
The high dose group was getting 1200mg (600mg TWICE/day for multiple consecutive days) of chloroquine diphosphate more toxic than hydroxychloroquine). Extremely high doses of a more toxic drug, in already very old and very sick patients. I could have designed a better study, myself.
Fluffy Pancakes

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04/13/2020 08:23 PM

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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
Personally, I'm growing weary of the interposed idiocy.
Things are bad enough, there is no need to make anything up. ~Fluffy

"Never interrupt an enemy in the process of destroying himself."

Quercitin and zinc...Get it. Take it.

Visit howbad.info...If you took the shot, for sure.
Anonymous Coward
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04/13/2020 08:27 PM
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Re: Brazil says Trump's corona virus cure chloroquine is killing people! they are forced to stop after fatal results! it's killing people!
...


its the same drug don't try to spin it.

Trump doesn't even know how many people it saved

[link to nypost.com (secure)]

Chloroquine has been eyed as a possible miracle treatment after President Trump has touted the drug, as a “one of the biggest game changers” to stop the coronavirus pandemic.
 Quoting: Anonymous Coward 69562936


This NYPOST hit-piece headlines this with chloroquine and then shows packages of hydroxychloroquine. They need to get their shit straight.
 Quoting: Pilgrim001


it's the generic version


it's like Sildenafil begin the generic version of Viagra
 Quoting: Anonymous Coward 69562936




You better tell the doctors.







Hydroxychloroquine = C18H26ClN3O
[link to pubchem.ncbi.nlm.nih.gov (secure)]

Chloroquine = C18H26ClN3
[link to pubchem.ncbi.nlm.nih.gov (secure)]


 Quoting: Anonymous Coward 78791928





GLP