Hoping Llamas Will Become Coronavirus Heroes

Winter is a 4-year-old chocolate-colored llama with spindly legs, ever-so-slightly askew ears and envy-inducing eyelashes. Some scientists hope she might be an important figure in the fight against the novel coronavirus.

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Humans produce only one kind of antibody ... Llamas, on the other hand, produce two types of antibodies. One of those antibodies is similar in size and constitution to human antibodies. But the other is much smaller; it’s only about 25 percent the size of human antibodies.

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In 2016, Dr. Saelens, Mr. Wrapp and Dr. Jason McLellan, a structural virologist at the University of Texas at Austin, and other researchers looked to llamas — and, specifically, Winter — to find a smaller llama antibody “that could broadly neutralize many different types of coronavirus,” Dr. McLellan said.

They injected Winter with spike proteins from the virus that caused the 2002-03 SARS epidemic as well as MERS, then tested a sample of her blood. And while they couldn’t isolate a single llama antibody that worked against both viruses, they found two potent antibodies that each fought separately against MERS and SARS.

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Winter’s picture... [link to imgur.com (secure)]