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Message Subject COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects /// October Lockdown for UK (pg. 774)
Poster Handle Anonymous Coward
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'Angry' cells
Scientists looked at the DNA of patients in more than 200 intensive care units in UK hospitals.
They scanned each person’s genes, which contain the instructions for every biological process - including how to fight a virus.
Their genomes were then compared with the DNA of healthy people to pinpoint any genetic differences, and a number were found - the first in a gene called TYK2.
“It is part of the system that makes your immune cells more angry, and more inflammatory,” explained Dr Baillie.
But if the gene is faulty, this immune response can go into overdrive, putting patients at risk of damaging lung inflammation.
A class of anti-inflammatory drugs already used for conditions such as rheumatoid arthritis targets this biological mechanism, including a drug called Baricitinib.

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