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Message Subject COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects /// October Lockdown for UK (pg. 774)
Poster Handle Anonymous Coward
Post Content
Sinovac has a different approach - not making the whole spike.

Another ...RED ALERT...?!

I am thinking about the problem of the vaccines having the spike and making prions... and WHY the Chinese would vaccinate their own if they knew..

This is the literature I have found about Sinovac/Coronavac.
They are INACTIVATED viruses.
Remember, the prion-genesis site is at position 500 on the spike, well within the S1 domain.

Below, the literature shows the S1 protein is cleaved off in the inactivated virus vaccines!

[link to www.biorxiv.org (secure)]
Both Moderna’s mRNA-1273 and Pfizer’s BNT162b2 (7) encodes full length S with two mutations to stabilise the prefusion conformation (8), and Sinovac’s CoronaVac inactivated virus vaccine presents the wild-type S on the viral surface (9), although the majority of spikes are in the postfusion conformation (10).



[link to www.ndm.ox.ac.uk (secure)]
The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET.
Although a small fraction of prefusion spikes are found, most spikes appear nail shaped, thus resembling a postfusion state, where the S1 protein of the spike has disassociated from S2

[link to www.cell.com (secure)]
There is consensus that the engagement of the S1 RBD with the receptor destabilizes the trimer, triggering the shedding of the S1 units, which allows a remarkable conformational change in the spike from a large club-shaped structure into a thin and long nail-like structure.
 Quoting: S-man
 
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