GOF research 2014 - what did they do to all of us? | |
Anonymous Coward (OP) User ID: 79251481 United States 08/11/2020 08:31 AM Report Abusive Post Report Copyright Violation | from above link At a 2014 meeting on infectious diseases, Dr. Kawaoka reported experiments whereby he forced the evolution of the pandemic H1N1 2009 virus so that it could escape from natural human antibody responses. The experiment was not complicated: it involved simply mixing virus with sera from individuals who had been naturally infected and selecting out the virus that was not neutralized. A total of 15 sites on the virus hemagglutinin protein were identified. Concentrating on five of these sites, he was able to produce strains that completely escaped human antibodies and extant vaccine coverage. This experiment is different from prior avian influenza virus gain of function (GOF) experiments in that we know the virus is readily transmissible among humans – after all these lab-made strains are derived from the pandemic H1N1 2009 virus! As the strains escape vaccine control, they constitute, unambiguously, a HUGE risk to man. |
Anonymous Coward (OP) User ID: 79251481 United States 08/11/2020 08:36 AM Report Abusive Post Report Copyright Violation | from link on 1st post And so it goes with influenza. While the initial papers on H5N1 showed that the hemagglutinin gene had acquired important mutations to allow it to bind to human receptor molecules in the upper respiratory tract, a subsequent paper showed that the same mutations did not confer the same phenotype on other H5N1 viruses currently circulating (19). This is not surprising to virologists, or scientists with knowledge of protein structure. The overriding question is how many solutions are out there? It may not be possible to answer this accurately, although with techniques such as saturation mutagenesis, it may be possible to asymptote toward defining a fraction for an individual flu protein. With regular exchange of avian influenza genes, it will be an extraordinarily difficult challenge. |
Anonymous Coward (OP) User ID: 79251481 United States 08/11/2020 08:40 AM Report Abusive Post Report Copyright Violation | |
R&y
User ID: 74857141 United States 08/11/2020 09:38 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 79251481 United States 08/11/2020 10:01 AM Report Abusive Post Report Copyright Violation | [link to www.nap.edu (secure)] On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, the United States government launched a one-year deliberative process to address the continuing controversy surrounding so-called "gain-of-function" (GOF) research on respiratory pathogens with pandemic potential. The gain of function controversy began in late 2011 with the question of whether to publish the results of two experiments involving H5N1 avian influenza and continued to focus on certain research with highly pathogenic avian influenza over the next three years. The heart of the U.S. process is an evaluation of the potential risks and benefits of certain types of GOF experiments with influenza, SARS, and MERS viruses that would inform the development and adoption of a new U.S. Government policy governing the funding and conduct of GOF research. On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, CRAZY RUNNING WITH THE DEVIL |
Anonymous Coward (OP) User ID: 79251481 United States 08/11/2020 10:07 AM Report Abusive Post Report Copyright Violation | [link to www.nap.edu (secure)] Quoting: Bayou Ice On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, the United States government launched a one-year deliberative process to address the continuing controversy surrounding so-called "gain-of-function" (GOF) research on respiratory pathogens with pandemic potential. The gain of function controversy began in late 2011 with the question of whether to publish the results of two experiments involving H5N1 avian influenza and continued to focus on certain research with highly pathogenic avian influenza over the next three years. The heart of the U.S. process is an evaluation of the potential risks and benefits of certain types of GOF experiments with influenza, SARS, and MERS viruses that would inform the development and adoption of a new U.S. Government policy governing the funding and conduct of GOF research. On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, CRAZY RUNNING WITH THE DEVIL Dr. Kawaoka regarding the attenuation of deadly influenza viruses—was exploited in the development of candidate H5N1 influenza virus vaccines, which were proven efficacious in clinical trials. Dr. Kawaoka has also employed reverse genetics in basic research. Using this technology, he identified a change in a single gene that is critical for bird flu viruses to cause severe disease in mammals. DR. KAWAOKA - IDENTIFIED A CHANGE IN A SINGLE GENE THAT IS CRITICAL FOR BIRD FLU VIRUSES TO CAUSE SEVERE DISEASE IN MAMMALS I found this in : Appendix D Speaker Biographies of the downloaded link from above there you go |
The Deplorable Truth
User ID: 79253499 United States 08/11/2020 10:10 AM Report Abusive Post Report Copyright Violation | |
The Deplorable Truth
User ID: 79253499 United States 08/11/2020 10:11 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 79251481 United States 08/11/2020 10:14 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 79251481 United States 08/11/2020 10:18 AM Report Abusive Post Report Copyright Violation | [link to www.nap.edu (secure)] lets talk about the Potential of inadvertent releases 30 minutes Session 6: Potential Risks of GoF Research I: Biosafety Moderator: Alta Charo, member of Symposium Planning Committee Focus: Potential for inadvertent releases, laboratory acquired infections, environmental health issues, and risk mitigation for pathogen research in general and as related to GOF research. Panel Discussion (10 minutes each) Barbara Johnson, Biosafety Biosecurity International Rob Weyant, Division of Select Agents and Toxins, U.S. Centers for Disease Control and Prevention Rebecca Moritz, Biosecurity Task Force, University of Wisconsin-Madison Marc Lipsitch, Harvard University Q&A Discussion (30 minutes) |
Anonymous Coward (OP) User ID: 79251481 United States 08/11/2020 10:21 AM Report Abusive Post Report Copyright Violation | [link to www.nap.edu (secure)] Risk Communication and Appropriate Involvement of Stakeholders (Haas, 2014:7).The major focus of attention with regard to GoF research has been on hazard assessment, which has largely been focused on occupational health risks, but it is important to go beyond this to consider risks to the members of the public near research sites as well as global risks from pandemic organisms. Scarce attention has been paid to either exposure assessment or dose response assessment (Haas, 2014:7-8). amazing |
Anonymous Coward (OP) User ID: 79251481 United States 08/11/2020 10:32 AM Report Abusive Post Report Copyright Violation | “In one of their studies, 155 bats were captured in Hubei province, and another 450 bats were captured in Zhejiang province. "The expert in the collection was noted in the Author Contributions.” The pair revealed how the lab had experienced two similar leaks in the last three years. It continued: “He was broadcasted for collecting viruses on nation-wide newspapers and websites in 2017 and 2019. “He admitted he was once attacked by bats and the blood of a bat shot on his skin. so just a little digging and the pure truth of it all comes from a Lab - and what are the details known from the Lab? this entire issue is so messed up just by the fact of not bringing clear truth to all by those that know the truth . So they had the bats What did they do with the bats they had ? What is the core pure truth of what was released from that Lab? |
SerenaSeesAll
User ID: 78926188 United States 08/11/2020 11:46 AM Report Abusive Post Report Copyright Violation | ============================================================= Noticing Miracles Is My Hobby The Bible - When you carry the Bible, Satan has a headache, when you open it, he collapses, when he sees you reading it, he loses his strength, AND when you stand on the Word of God, Satan can't hurt you! |
Anonymous Coward User ID: 75918984 United States 08/11/2020 11:50 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 79251481 United States 08/11/2020 01:42 PM Report Abusive Post Report Copyright Violation | So what then? We just keep catching it until it finally kills us? Quoting: Anonymous Coward 75918984 they intend to kill you with fear people run to safety at the point of fear they will give you the pre-planned answer take a shot and all is fine that shot is the start of you selling your soul for life in this flesh ever lasting life only comes if you say no to life in this flesh to that offered it's the reset with One World Rule simple truth to a complex ending event The Bible has this story but no body wants to hear or read about what the Bible has to say about the subject Good luck with all this that is falling on your head |