Possible pathway for Covid-19 activation of acute toxoplasmosis (i.e provoked egress)

Covid-19 seems to create a high concentration of Ca2+, which is the trigger for synchronous egress of Toxoplasma tachyzoites which leads to acute toxoplasmosis. Morphological signaling.


Ca2+ pathway for Covid-19 activation of acute toxoplasmosis:

Covid-19: Lysosomal and plasma membrane TRPM2, cause Ca2+ influx across the plasma membrane and release of lysosomal Ca2+, providing high concentration of Ca2+ in the cytosol. The overload of cytosolic Ca2+ initiates apoptosis and probably necrosis”

Toxoplasma: “Egress can be artificially induced by Ca2+ ionophores” and “Synchronous egress can be triggered by Ca2+”

(Please also note that Hydroxychloroquine slows Ca2+, hence slows down the development of acute toxoplasmosis: “treatment with hydroxychloroquine is associated with a dose-dependent
downregulation of the co-stimulatory molecule CD154 on CD4+ T cells, which is accompanied by a decrease in intracellular Ca2+ mobilization “)