Blocking the Spike Using Herbs that Bind to the Spike.

From a friend who is a pharmaceutical scientist:

The following paper measured the degree to which 12 different herbs bind to the active site of the spike protein thereby preventing it from binding to human cells and doing damage. Here is what they found -
We analysed the binding efficiency of twelve compounds present in common herbs with the S protein of SARS-CoV-2 through molecular docking analysis and also results are validated with two different docking tools.
The binding efficiency of ligands was scored based on their predicted pharmacological interactions coupled with binding energy estimates.
In docking analysis, compound "I"(Epigallocatechin gallate (EGCG)) was found to have the highest binding affinity with the viral S protein, followed by compounds, "F"(Curcumin),"D"(Apigenin) and "E"(Chrysophanol).
The present study corroborates that compound "I"(EGCG) mostly present in the integrants of green tea, shows the highest potentiality for acting as an inhibitor of SARSCoV- 2.
Further, characterization of the amino acid residues comprising the viral binding site and the nature of the hydrogen bonding involved in the ligand-receptor interaction revealed significant findings with herbal compound "I"(EGCG) binding to the S protein at eight amino acid residues. The binding sites are situated near to the amino acids which are required for virus pathogenicity.
Anyway, here is the paper, bought to my attention by Erica Khan (NASA biologist) : [link to www.nature.com (secure)]

1. Ivermectin Blocks the Spike :
[link to pubmed.ncbi.nlm.nih.gov (secure)]
2. Suramin Blocks the Spike :
[link to www.biorxiv.org (secure)]
3. Herbs Block the Spike :
[link to doi.org (secure)]
[link to search.bvsalud.org (secure)]
609451
4. Spike Binds to ACE2 :
[link to ajpheart.podbean.com (secure)]
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62ysPknkHc7nsepwnExEh6J1BvdJwokDAYtmdutkHcZtqLr_yHWg
[link to www.ncbi.nlm.nih.gov (secure)]
[link to www.tandfonline.com (secure)]
5. Angiotensin II Releases Thrombin :
[link to pubmed.ncbi.nlm.nih.gov (secure)]
6. Angiotensin II Releases Endothelins :
[link to www.ahajournals.org (secure)]
7. Thrombin Causes Clotting :
[link to www.britannica.com (secure)]
8. Endothelins Cause Vaso-Constriction:
[link to www.ahajournals.org (secure)]
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usions%20Selective%20ETB%20receptor,ETB%20receptors%20mediate​%20vasoconstriction.
9. General Background :
[link to www.ncbi.nlm.nih.gov (secure)]

Last Edited by NadaConnorJr on 06/13/2021 09:05 PM