More MARBURG cases! More suspected EBOLA cases! More MERS cases!

Combination therapy protects macaques against advanced Marburg virus disease

[link to www.nature.com (secure)]

And now we wait...

Symptomes Marburg virus

Nausea, vomiting, chest pain, a sore throat, abdominal pain, and diarrhea may then appear. Symptoms become increasingly severe and can include jaundice, inflammation of the pancreas, severe weight loss, delirium, shock, liver failure, massive hemorrhaging, and multi-organ dysfunction.

Marburg virus disease transmission

Marburg spreads through human-to-human transmission via direct contact (through broken skin or mucous membranes) with the blood, secretions, organs or other bodily fluids of infected people, and with surfaces and materials (e.g. bedding, clothing) contaminated with these fluids.

Transmission can also occur by contact with dead or living infected animals, including bushmeat (e.g. monkeys, chimpanzees, forest antelopes, and bats) or by visiting caves or mines colonised by bats

[link to www.ecdc.europa.eu (secure)]

Last Edited by x_dutch_x on 08/11/2021 10:03 PM

Marburg viruses can persist in immune-privileged sites of certain survivors such as testicles, central nervous system and aqueous humour from which new transmissions can potentially arise, notably through sexual transmission

[link to www.ecdc.europa.eu (secure)]

The next pandemic: Marburg?
22 April 2021

There are currently no specific therapeutics for Marburg virus. However, supportive care including rehydration with oral or intravenous fluids can improve survival. This can mean maintaining oxygen status and blood pressure, replacing lost blood and clotting factors, and treating any complicating infections.

[link to www.gavi.org (secure)]

80 % death rate. You WILL want a vaccine against this.

The risk for global spread is high

Pandemic threat: As Marburg virus can spread from human to human through contact of bodily fluids, much like Ebola. As outbreaks in Europe and the US have already shown, increasing globalisation and international travel mean that the risk for global spread is high, especially when the incubation period could be up to three weeks. This could be disastrous given its high death rate

[link to www.gavi.org (secure)]

There is a drug, but .....


BioCryst Completes Phase 1 Clinical Trial of Galidesivir

[link to ir.biocryst.com (secure)]


BioCryst Provides Update on Galidesivir Program

[link to ir.biocryst.com (secure)]


Biological Activity for Galidesivir dihydrochloride
Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50 values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models

Pricing Availability Qty2 mg / $195 In Stock

[link to www.tocris.com (secure)]

Until now there are o more Marburg cases detected, so we just have to wait...

Welcome to Plague Planet!

In Ivory Coast a 18 year old woman from Gunee has got Ebola


[link to www.barrons.com (secure)]

Ivory Coast reported the country’s first case of Ebola in more than 25 years on Saturday, in Abidjan — a city of more than 4 million people.

The dangers of Ebola in urban areas: The World Health Organization expressed concern that the case was identified in a densely populated urban area as during the massive West Africa outbreak of 2014-2016, Ebola entered Liberia’s capital, Monrovia, and the outbreak quickly accelerated beyond control.

[link to www.devex.com (secure)]

Ivory Coast begin vaccinating health workers in the commercial capital Abidjan against Ebola on Monday after a case of the deadly virus was confirmed over the weekend.


In total, health authorities have identified nine people the woman came into contact with, including three family members and six hospital staffers, the World Health Organisation (WHO) told partners in a report. The woman and one suspected Ebola case are in hospital, it said.

[link to www.news24.com (secure)]

The time interval from infection with Ebola to the onset of symptoms is 2-21 days, although 8-10 days is most common. Signs and symptoms include:

fever
headache
joint and muscle aches
weakness
diarrhea
vomiting
stomach pain
lack of appetite

Some patients may experience:

rash
red eyes
hiccups
cough
sore throat
chest pain
difficulty breathing
difficulty swallowing
bleeding inside and outside of the body

[link to www.medicalnewstoday.com (secure)]

One vaccine, called Ebola ça suffit, was found to be 100 percent effective in a trial involving 4,000 people in Guinea

[link to www.medicalnewstoday.com (secure)]

25/02/21
Ebola: 20,000 vaccine doses to tackle Guinea outbreak

[link to www.scidev.net (secure)]

Such experiments have found hints of ADE with viruses including Ebola virus, HIV, and coronaviruses such as SARS and MERS

[link to www.the-scientist.com (secure)]

The World Health Organization (WHO) said Tuesday that a second suspected case of infection by the deadly Ebola virus had been detected in Ivory Coast.

1 suspected case and 9 contact cases have been identified and are being followed up, says WHO

[link to www.aa.com.tr (secure)]

He said the WHO was “very concerned” about the ability of the virus to spread in the West African country’s economic hub Abidjan, with a population of more than four million.

[link to von.gov.ng (secure)]

The confirmed case has been identified as an 18-year-old from Guinea who travelled overland, arriving in Abidjan last Wednesday aboard a bus. When she left Guinea, she was already exhibiting symptoms that continued to intensify.

[link to von.gov.ng (secure)]

"Bavarian Nordic"? Well, now...

Oh…. 90%. So you are saying we have a chance? Phew….

MMS stops Marburg and Ebola dead in their tracks. Works on every virus.

Monrovia – The World Health Organization (WHO)-Liberia Country Office has notified the National Public Health Institute of Liberia (NPHIL) of two confirmed cases of Marburg Hemorrhagic Fever in Gueckedou, the Republic of Guinea.

[link to frontpageafricaonline.com (secure)]

Liberia has heightened cross-border surveillance to quickly detect any cases, with all neighbouring counties on HIGHEST alert. The Ebola control systems are in place in Liberia and the health sector is finalizing “Marburg Preparedness and Response plan.

[link to frontpageafricaonline.com (secure)]


Maybe de second Marburg case, is the first Ebola case?
I'm looking for more info, Anybody??

Last Edited by x_dutch_x on 08/19/2021 04:02 AM

Between 12 March and 31 July 2021 , the National IHR Focal Point of Saudi Arabia reported four additional cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection, including one associated death.

[link to www.who.int (secure)]

Between September 2012 until 31 July 2021, a total of 2578 laboratory-confirmed cases of MERS-CoV and 888 associated deaths were reported globally to WHO

[link to www.who.int (secure)]

Approximately 35% of patients with MERS have died, but this may be an overestimate of the true mortality rate, as mild cases of MERS-CoV may be missed by existing surveillance systems and until more is known about the disease, the case fatality rates are counted only amongst the laboratory-confirmed cases

[link to www.who.int (secure)]

Based on the current situation and available information, WHO re-emphasizes the importance of strong surveillance by all Member States for acute respiratory infections and to carefully review any unusual patterns

[link to www.who.int (secure)]