A whole city in Brazil was offered Ivermectin

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Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching
Published: January 15, 2022

(conducted between July 2020 and December 2020 in Itajaí, Brazil.)


Page 5: SUMMARY OF CITY-WIDE POPULATION USED FOR STUDY, EXCLUSIONS, INFECTION RATES.
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Page 8: SUMMARY OF RESULTS: INFECTION, HOSPITALISATION, DEATH
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Study interventions:
Ivermectin was offered as an optional treatment to be taken for two consecutive days every 15 days at a dose of 0.2 mg/kg/day.

In cases where a participating citizen of Itajaí became ill with COVID-19, they were recommended not to use ivermectin or any other medication in early outpatient treatment.


Method:
From the registry of the city population (223,128 inhabitants),
Subjects below 18 years old (61,583 subjects) were removed.
Of the 161,545 subjects above 18 years old from the city of Itajaí, we removed the 1,984 COVID-19 cases that occurred before July 7, 2020,
and 159,561 subjects remained.

Of the 223,128 citizens of Itajaí considered for the study, a total of 159,561 subjects were included in the analysis:
113,845 (71.3%) regular ivermectin users and 45,716 (23.3%) non-users.

Of these, 4,311 ivermectin users were infected, among which
4,197 were from the city of Itajaí (3.7% infection rate), and
3,034 non-users (from Itajaí) were infected (6.6% infection rate).
BOOM #1: 44% reduction in COVID-19 infection rate

--------- THEN, AMONGST THE INFECTED... ---------

Two cohorts of 3,034 subjects suffering from COVID-19 infection were compared.
- IMPORTANT: for every case in the "non-ivermectin" group, a corresponding case was found in the ivermectin users' group (matched age etc).


BOOM #2: regular use of ivermectin led to a 68% reduction in COVID-19 mortality
(25 [0.8%] versus 79 [2.6%] among ivermectin non-users)

BOOM #3: There was a 56% reduction in hospitalization rate
(44 versus 99 hospitalizations among ivermectin users and non-users, respectively.)

NOTE: the paricipants were ONLY using Ivermectin prophylactically, and advised to STOP taking it if they got COVID, yet the study STILL got the results above!


Housekeeping:
Hospitalization and mortality rates *before* matching groups &
the mortality rate in subpopulations *before* and *after* PSM [i.e. matching]
...are presented in the Appendix.