FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects

[link to www.statnews.com (secure)]

FDA pulls Evusheld authorization as coronavirus evolution quashes another therapy

[link to www.cbsnews.com (secure)]

FDA advisers vote to simplify COVID vaccines, retire original "monovalent" shots

[link to www.thestar.com (secure)]

Is COVID still a global health emergency? WHO will decide Friday
World Health Organization will declare if it’s still a Public Health Emergency of International Concern. But either way the virus is still with us.

Only thing I know is day/month/year pass very fast.





[link to thewalrus.ca (secure)]

Why We Made Fewer Memories during the Pandemic
Monotony and anxiety wrought havoc on our brains. Can we bounce back?

Hi Doc, thanks for keeping us update, reduce volume or frequency if can't take it initially, then increase more down the road when you body get used to it. :-)

The current #Omicron subvariant BA.5 has a similar cell-damaging effect as Delta"

https://twitter.com/_/status/1618801288145412096

[link to www.uni-ulm.de (secure)]

Heart muscle cells stop beating earlier
Current omicron subvariant BA.5 damages cardiomyocytes more than BA.1
A study by the University Hospital Ulm examined how well different variants of the SARS-CoV-2 coronavirus multiply in cultivated human heart muscle cells. The results show that the original omicron subvariant BA.1 spreads only to a very limited extent in myocardial cells. The current BA.5 subvariant, on the other hand, can infect cardiomyocytes as effectively as the earlier Delta variant. Additional mutations are responsible for this - above all in the spike protein, which strengthen the infectivity and cell-damaging effect of BA.5. The results were published in the Nature journal

Last Edited by whitepiedtv on 01/27/2023 04:45 AM

BA.5 has NO NEW TISSUE TROPISMS.
It has higher ACE2 affinity (bonds harder and faster).
It CAN NOT cleave the cell membrane with its 'Furin Cleavage Site' but the extra bonding to ACE2 gives it more of a chance to stick.

Once the virus has 'stuck' to the cell membrane, it uses endocytosis to get access to the cells, not Furin.

This is all preventable with Cathepsin blockers like HCQ.
Also Ivm has like 11 MoA's against viruses.

The higher ACE2 affinity is likely driven by leaky vaccines, btw.


Keep Calm.
Treat covid if you are unlucky enough to get it.

Last Edited by S-man on 01/27/2023 05:02 AM

George Washington University study, between July 2021 and March 2022.

“Of the 1,338 cases, 36% of people reported experiencing symptoms consistent with LongCovid. Nearly three-quarters of respondents were students; the rest were faculty or staff.”

https://twitter.com/_/status/1618752523585855488

So now they leave us with bivalent ones - the worst of both worlds..

1. OG spike factories with Prion-genesis zones (for the now-extinct Wuhan-1 version)

and

2. Spike factories for the-also-now-extinct early Omicron version which have a higher ACE2 affinity and block the ACE2 receptors messing up the renin-angiotensin system..

yeah. gr8.
OBVIOUS FDA works with pharma in the revolving door mechanism described by Project Veritas' latest (amazing) hit piece.

Last Edited by S-man on 01/27/2023 05:01 AM

Hi S-man, if we are not allowed access or don't have HCQ and Ivermertin, what about this research from Sep 2022?


[link to www.thelancet.com (secure)]

SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern



The key difference of BA.5 from other Omicron sub-variants is the reversion in tropism back to using the well-known ACE2-TMPRSS2 pathway, utilised efficiently by pre-Omicron lineages.

Last Edited by whitepiedtv on 01/27/2023 05:18 AM

Omicron also went into our blood.

[link to www.cedars-sinai.org (secure)]

Study: Most People Infected With Omicron Didn’t Know It

Of the healthcare workers and patients who have participated in the research, investigators identified 2,479 people who had contributed blood samples just prior to or after the start of the Omicron surge. The investigators identified 210 people who likely were infected with the Omicron variant based on newly positive levels of antibodies to SARS-CoV-2 in their blood.

As a qualified accountant i should understand this a bit more.

https://twitter.com/_/status/1618633454983458818

BREAKING - The National Audit Office has been unable to sign-off the UK Health Security Agency 2021/22 accounts as:

"There was a lack of adequate governance, oversight & control at UKHSA."

Balances unaccounted for:

• £794m of stock
• £1.5bn of accruals from NHS Test & Trace


But it seems to be that £1.5bn of cash is missing in relation to the NHS Covid Test and Trace debacle.

As I have said, Omicron uses the ACE2 receptor to 'stick', but not for entry.. It does NOT fuse using Furin. They are speculating in this article that the use of Nafamostat implies BA5 is using TMPRSS2 but we don't see clinical evidence of that - and we don't have hospitals packed out with BA.5 pneumonias, do we? Nope.


If you don't have HCQ or Ivm by this stage, you need to get it. Have it ready.... and to say 'not allowed' - are you still respecting government dictats that say you are 'not allowed' to help yourself???? It's clear you have a duty to yourself, family and friends to break these rules.


BTW, The "Evasion of humoral immunity " is explained below:

[link to hiddencomplexity.substack.com (secure)]
I SUGGEST GRABBING THE DIAGRAM LABELLED "Mutations located in spike protein..." AT THIS^ SUBSTACK
(It shows the definitive mutations in the BA lineage in graphical form, you can see the Omicron P->H change at the Furin Cleavage Site position 681 PRRAR -> HRRAR, for example.)

"but your focus is and should be the mutations, save the image or mark them down, even if you don’t understand molecular biology, it will serve you well as the years go by."

"Trying to clarify what exactly goes on at a neutralization level and find if the antibodies the immune system produces which are aimed, or “fixated” in the Wuhan virus/spike protein the authors found that after a long enough period, the majority of the group in the study were not able to neutralize the virus, and none against Omicron. 2 doses vaccinated maintained a decent neutralization rate against Wuhan, but fall by 30% against BA. 2 and further falls against BA. 4/5 and 2.75 (average of 23% against these last ones), neutralization capacity was rescued and enhanced after a BA. 2 infection. What has been referred to months ago as a “natural booster” from an Omicron infection."


Damaged immune systems. It's a thing.
It's why they won't give us useful data any more.

Last Edited by S-man on 01/27/2023 06:26 AM

Today's substack post from Walter Chestnut giving hope for more tx against the spike protein damage.

Possibly helps reduce the damage from aging, which has been shown from the spike protein. Something for hope instead just gloom and doom.

We do not have to be victims despite the psyop currently working to demoralize and make people believe they are helpless.

This is not any kind of nutritional or medical advice but some of the commenters shared their product of choice for cell repair and anti aging.


ResveraCel by Thorne
Tru Niacin
Amptogen


[link to wmcresearch.substack.com (secure)]

Friday Hope: Nicotinamide Riboside: A Compound Which Facilitates DNA Damage (Mistranslation) Repair
A Potential Powerful Therapeutic for COVID, Long COVID and Spike Protein Progeria Disease


...I believe a very powerful therapeutic against this mistranslation damage is Nicotinamide Riboside. So, first, what is Nicotinamide Riboside?

Nicotinamide riboside (NR) is an additional salvageable NAD+ precursor with a two-step or three-step pathway to form NAD+. Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits mediated via elevated NAD+ content in the body. NAD+ is an essential coenzyme that plays important roles in various metabolic pathways and increasing its overall content has been confirmed as a valuable strategy for treating a wide variety of pathophysiological conditions. Accumulating evidence on NRs’ health benefits has validated its efficiency across numerous animal and human studies for the treatment of a number of cardiovascular, neurodegenerative, and metabolic disorders.

Nicotinamide Riboside—The Current State of Research and Therapeutic Uses
[link to www.ncbi.nlm.nih.gov (secure)]

Why I believe this compound is important in the treatment of COVID, Long COVID and SPPD, is because it addresses the very kind of damage I believe the evidence shows the Spike Protein is causing. ...

Covid or the jabs. Or both!

From personal local contacts it’s the jab.

https://twitter.com/_/status/1619057772741693441

Last Edited by ParamedicUK on 01/27/2023 03:51 PM

On Eric Ding-Dong's preprint... I think its conclusion is flawed.

[link to www.medrxiv.org (secure)]
"we identified individuals with polymerase chain reaction (PCR)-confirmed COVID-19 through December 31, 2020. Patients were matched 1:3 to control patients without COVID-19."

"Both groups were followed up until June 30, 2021."

They state explicitly:
"Only patients from 2020 were selected, as this ensured that the effect was not influenced by vaccinations"


Buuut.. this date of 30 June 2021 still allows for all those patients (and controls) getting vaccinated.
So vaccination can't be excluded as the cause of the autoimmunity.

Now, thinking deeper: It might be a reasonable assumption that the two groups 'control' (uninfected) and the infected cohorts got vaccinated at roughly equal rates? But they do NOT say that in the preprint.

-> The 'infected' group will have been exposed to more spike if infected and vaccinated.
-> The 'infected' group will also have had exposure through natural mucosal barriers FOLLOWED by an unnatural exposure into the deltoid muscle - and thence who knows where...

It seems to me, at least, that this paper fails to address any of these important biasses/confounders - so it is poor science to assert that covid is the cause of the autoimmune diseases.

Last Edited by S-man on 01/27/2023 05:10 PM

On a lighter note..

My OH said the Project Veritas video was
"like 28 days later meets an episode of 'Cheaters'".


Right, off to have a dram or two of the good stuff.
It's Friday night.


Last Edited by S-man on 01/27/2023 05:21 PM

Cheers, Chaps! Happy Friday!

What the actual fuck BBC

https://twitter.com/_/status/1619125660227702784

Could a fungal pandemic turn us all into zombies?

The last of us series on hbo steaming foreshadows that assumption.

there is a TV show that came out recently bout that.

"The Last of Us is an American post-apocalyptic drama television series created by Craig Mazin and Neil Druckmann for HBO. Based on the 2013 video game developed by Naughty Dog, the series is set twenty years after a mass fungal infection caused by a mutation in the genus Cordyceps, which sparked a global pandemic. " WIKI

Thanks S-man, found something very important and useful in your link.

I won’t explain why, how, the mechanism, the pathway, or even allude to it, but if you are vaccinated, you should 100% get into Berberine or Metformin as soon as you are able. Not optional. Take it or leave it, any comment about this section of this substack will be summarily deleted. Advise the unvaccinated to add these too.



:-) For the HCM and Ivermectin, maybe let me rephrase (although I still can't get the Ivermectin).

As we know, we can be infected with Covid19 without having any symptoms at all and thus we will miss the opportunity to use HCQ and Ivermectin.

Research shows that 56% were unaware they were infected with virus that causes covid-19
[link to www.cedars-sinai.org (secure)]

In this scenario, I am trying my best to figure out (after missing the chance to use HCM and Ivermectin) how the BA.5 or any latest variant can harm our body.

Also, without the FCS, the BA.5 can't enter the body thorough the ACE2 + TMPRSS2, but other Omicron variants can still go through the other route as shown below through ACE2 + CTSL entry route now.

[link to www.nature.com (secure)]

We confirmed that CTSL cleavage is essential during infection of all emerged SARS-CoV-2 variants (including the recently emerged Omicron variant) by pseudovirus (PsV) infection experiment.

Results

CTSL cleaves the SARS-CoV-2 S protein at two specific sites
The trimeric S protein that incorporated into the SARS-CoV-2 envelope contains S1 and S2 subunits (Fig. 1a, b). The S1 subunit binds to the host cellular receptor, while the S2 subunit is involved in the virus-cell membrane fusion process, which is followed by the release of viral genetic material into target cells.

The internal organ it can possible harm are those with single green dot below which includes heart, liver and placenta etc.

https://imgur.com/UAxEuyG

ABOVE: Human cell types within corresponding organs that express the genes for both ACE2 and CTSL (green dot) or both ACE2 and TMPRSS2 (orange dot).


[link to www.the-scientist.com (secure)]

Receptors for SARS-CoV-2 Present in Wide Variety of Human Cells
Analyses from single-cell sequencing datasets support the idea that COVID-19 is not just a respiratory disease but an illness that can affect multiple organs.


[link to www.business-standard.com (secure)]

Omicron sub-variants may target lungs, evade vax, prior infection: Studies
A preliminary study from the University of Tokyo showed that BA.4, BA.5, and BA.2.12.1 may have evolved to cause infection of lung cells

Sato's experiments indicate that BA.4, BA.5 and BA.2.12.1 replicate more efficiently in human lung cells than BA.2, while further experiments in hamsters suggest that BA.4 and BA.5 may cause more severe disease, the report said.

"It looks as though these things are switching back to the more dangerous form of infection, so going lower down in the lung," Dr Stephen Griffin, a virologist at the University of Leeds, was quoted as saying.


[link to academic.oup.com (secure)]

First report of myocarditis in two patients with COVID-19 Omicron variant: case report

https://twitter.com/_/status/1616624594638495744

Last Edited by whitepiedtv on 01/27/2023 10:38 PM

i gave the show a wirl. starts with a news discussion in 1968 when u could still smoke on TV. odd start. suggests it could start if the planet warmed a few degrees. then jumps to 2003 with an outbreak in Texas, and then to 2023 to apocalyptic Boston.

yawn. not much info on how it starts. slow drama. bout fell alseep trying to find a storyline. jumps around too much.

basically a fungus can get into the brain and contol ppl like it does ants. time to full infection on face or neck is < 15 mind. few hours if lower, legs is half to full day. symptoms list looks like those for a stroke.
-----------------------------------------------------------

is it possable? doubtful with buts. no pathogen can do this damage this fast. 2 exceptions- some snake bites can kill quickly. some drugs can cause loss of memory but temporary. have heard of a drug out of Brazil that does give 1 the power to suggest things to another and that person won't have any memory of it later. in higher doses, the serum kills. in the right does, u could have them give u their $$, and they never remember that they did. however, not long lasting. person regains normal brain function in a short bit of time, few hours.

now with this we don't know what all was added to make covid. we speculate. there is some evidence that suggests it could go sideways. not just merge and mutate with viruses but also other nasties, such as fungi or bacteria. i understand it is arguementative at the moment as the vax has disrupted the immune systems of many.

even if covid could mutate with fungus, i do not see a zombie scenario being realistic. at least not like TV. several problems. 1 being the pathogen can not infect or disrupt the mind fast enuf. nor do they kill in seconds after a bite. a zombie host, which is what u would b if controlled by a fungus or other pathogen, can still die from loss of blood or starvation. it would still need food and water. u wouldn't see whole groups of ppl turn into zombies just from simple bites. they wouldn't walk around after huge blood loss. they wouldn't stop feeding to attack u. stay away from them and they'll starve on their own.

that's the good news. the bad is we have seen similar. ppl with covid lose brain critical thinking. become more animalistic in attitudes. and these ppl use tools, drive, can climb stairs, etc. without human morals, these ppl would b dangerous. i think we all know by nbow how fast our govern's work to foresee and notify the public of such dangers. it would b spread all over while the big wigs fly away and hide. unlike TV, the show would b short.

think of something spreading via sweat. how long would it take to spread thru a metro? a month or so? how long to disrupt brain function from infection? 3 days? in 3 days, how many others do u have contact with directly? bout 5-10? see how slow that would b to encompass a huge city? sux if u are patient zero. but otherwise avoidable easily.

Gosh, what a lot of random points to assess... :)


Ok on Ivermectin: Did you try Alldaychemist.com or veterinary suppliers?

If you are fearful of 'no-symptom' damage, then you could use it prophylactically, if there has been exposure.
Your immune system should tell you, though, if your heart is being damaged by anything at all.

Last Edited by S-man on 01/28/2023 09:22 AM

On myocarditis in Omicron: the journal paper you quoted was published in October'22.
(IMO, not since really corroborrated in larger real-world observations... but hey let's look...)

[link to academic.oup.com (secure)]

They looked at two cases....both vaxxed, and one with prior 2008 inflammation:
Case 1:
"His medical history was remarkable for prior peri-myocarditis in 2008 without clear aetiology"
"The patient received three doses of BNT162b2 mRNA vaccines (third dose on 22 August 2021)"

Case 2:
"He was vaccinated with three doses of BNT 162b2 mRNA COVID-19 vaccine (third dose on 30 August 2021)."

Myocarditis in covid so far does not exceed the normal background rate in huge studies, like I posted in this thread...

THREAD: Thread: Myocarditis from the JABS -not covid- Here is the evidence I gathered. Counter the junk journalism!

Now, let's look at this statement:


I am thinking that ACE2 plus 'xxxx' entry would have been something of a feature in MANY variants --SARS2 has MANY receptor entry routes (most are not very effiient, thankfully...)-- it's just that Omicron binds to ACE2 so much better, so we see it more.
But the main route of entry is still, I believe:
ACE2 to 'stick', and then endocytosis.
-> The endocytosis route is inhibited by HCQ.
-> The other routes of infection and replication after infection are minimised by Ivm and other antivirals

You should also bear the following in mind, because it gives an idea of just how much of a problem the Furin/TMPRSS2 entry was compared even to other receptors:
-> RxxR is a 'standard' Furin Cleavage Site.
-> RRxR is a 100-1000x more functional as a Furin Cleavage Site.. Wuhan-1 had this, and it was functional. THIS is why Wuhan-1 etc. were so dangerous.

PS I do NOT want to think about how insanely functional RRRR or RRRRR might be (one mutation I saw had Omicron HRRAR -> RRRAR, just one mutation away from RRRRR.)
Of course, the adjacent QTNSPRRAR (of Wuhan-1), changed to QTKSHRRAR (Omicron), -that's what makes the 'RRAR' bit 'non-functional' anyway.
But I still worry about RRRR or RRRRR.

Last Edited by S-man on 01/28/2023 09:25 AM

WPTV, your business-standard article is from June 2022.
The upshot is Omicron bonds better to ACE2 than Delta or earlier versions, BUT it does not use any new method of infection.
Again, we'd have seen it! - No ICUs packed with Omicron pneumonias.
I remember you quoted Steven Griffin, and I marked him as a 'fearmongerer' from way back, too:



Last Edited by S-man on 01/28/2023 09:26 AM

https://twitter.com/_/status/1618920828409884672

Is the second wave of diarrheal pneumonia and encephalitis on the way? Recently, a large number of online videos have shown that a large number of "secondary infections" have occurred in various parts of China, and viral "encephalitis" has also appeared in many places...

Just recording this thread, too...WOW. Pfizer need to be investigated RIGHT NOW.

Thread: Remember the 100 lab monkeys that 'escaped' near a Pfizer lab in Pennsylvania?
Remember the 100 lab monkeys that 'escaped' near a Pfizer lab in Pennsylvania?

What a crime against humanity the drug-pushers committed.
They skipped repurposing of safe drugs and invoked known mutagenic and dangerous drugs like molnupiravir.

[link to www.medrxiv.org (secure)]
Identification of a molnupiravir-associated mutational signature in SARS-CoV-2 sequencing databases

From the author:
"We conclusively demonstrate that mutational events caused by molnupiravir treatment can be seen in globally sequenced SARS-CoV-2 genomes, in some cases with onwards transmission."
(quote from author Theo Sanderson here: [link to nitter.grimneko.de (secure)] )


REMINDER: this was known before they released it, and WE, here on GLP, called them out for it!

MHRA: LIARS!!!