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FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
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S-man |
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I warned you loud and clear that this was a prion warfare agent. I caught hell for it here. Here is more proof. More will come. More will come. [ link to www.biorxiv.org (secure)] Background: The coronavirus disease 19 (COVID-19) has represented an issue for global health since its outbreak in March 2020. It is now evident that the SARS-CoV-2 infection results in a wide range of long-term neurological symptoms and is worryingly associated with the aggravation of Alzheimer's disease.
Little is known about the molecular basis of these manifestations. Methods: Several SARS-CoV-2 strain variants were used to infect SH-SY5Y neuroblastoma cells and K18-hACE C57BL/6J mice. The Tau phosphorylation profile and aggregation propensity upon infection were investigated using immunoblot and immunofluorescence on cellular extracts, subcellular fractions, and brain tissue.
The viral proteins Spike, Nucleocapsid, and Membrane were overexpressed in SH-SY5Y cells and the direct effect on Tau phosphorylation was checked using immunoblot experiments. Results: Upon infection, Tau is phosphorylated at several pathological epitopes associated with Alzheimer's disease and other tauopathies.
Moreover, this event increases Tau's propensity to form insoluble aggregates and alters its subcellular localization.
Conclusions: Our data support the evidence that SARS-CoV-2 infection in the Central Nervous System triggers downstream effects altering Tau function, eventually leading to the impairment of neuronal function.oh, heck.. can you imagine when the penny drops and the size of the mistake is quantified regarding gene-transfecting with this protein? Likely it's reverse-transcribed or integrated via the plasmids into the host DNA. It will thus be an overwhelming cascade of tau.
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