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BREAKING: Health Canada to authorize Pfizer's antiviral COVID-19 drug | |
| Google_It
Offer Upgrade  User ID: 80175631  Canada01/17/2022 10:16 AM  Report Abusive Post Report Copyright Violation | |
| Anonymous Coward User ID: 77811278 Canada01/17/2022 10:25 AM Report Abusive Post Report Copyright Violation | |
| Anonymous Coward User ID: 77811278 Canada01/17/2022 10:26 AM Report Abusive Post Report Copyright Violation | Ritonavir-boosted nirmatrelvir (Paxlovid) has significant and complex drug-drug interaction potential, primarily due to the ritonavir component of the combination. Boosting with ritonavir, a strong cytochrome P450 (CYP) 3A inhibitor, is required to increase the exposure of nirmatrelvir to a concentration that is effective against SARS-CoV-2. Ritonavir is an FDA-approved drug that has been used for more than 2 decades as a pharmacologic boosting agent for certain anti-HIV medications |
| Anonymous Coward User ID: 81845295 Canada01/17/2022 10:27 AM Report Abusive Post Report Copyright Violation | |
| Anonymous Coward User ID: 77811278 Canada01/17/2022 10:27 AM Report Abusive Post Report Copyright Violation | Ritonavir-boosted nirmatrelvir (Paxlovid) has significant and complex drug-drug interaction potential, primarily due to the ritonavir component of the combination. Boosting with ritonavir, a strong cytochrome P450 (CYP) 3A inhibitor, is required to increase the exposure of nirmatrelvir to a concentration that is effective against SARS-CoV-2. Ritonavir is an FDA-approved drug that has been used for more than 2 decades as a pharmacologic boosting agent for certain anti-HIV medications clinicians should consider the risks and benefits of using ritonavir-boosted nirmatrelvir (Paxlovid). Expert consultation (e.g., with a clinical pharmacist, HIV specialist, and/or the patient’s specialist provider, if applicable) should be considered, especially for patients receiving highly specialized therapies, such as antineoplastics, neuropsychiatric drugs, and certain immunosuppressants. |
| Anonymous Coward User ID: 77811278 Canada01/17/2022 10:29 AM Report Abusive Post Report Copyright Violation | Ritonavir-boosted nirmatrelvir (Paxlovid) has significant and complex drug-drug interaction potential, primarily due to the ritonavir component of the combination. Boosting with ritonavir, a strong cytochrome P450 (CYP) 3A inhibitor, is required to increase the exposure of nirmatrelvir to a concentration that is effective against SARS-CoV-2. Ritonavir is an FDA-approved drug that has been used for more than 2 decades as a pharmacologic boosting agent for certain anti-HIV medications clinicians should consider the risks and benefits of using ritonavir-boosted nirmatrelvir (Paxlovid). Expert consultation (e.g., with a clinical pharmacist, HIV specialist, and/or the patient’s specialist provider, if applicable) should be considered, especially for patients receiving highly specialized therapies, such as antineoplastics, neuropsychiatric drugs, and certain immunosuppressants. Last one>>> thus, administration of this treatment with or immediately after discontinuing medications that are strong inducers of CYP3A4 (e.g., rifampin) can lead to significant reductions in nirmatrelvir and ritonavir concentrations, which may decrease nirmatrelvir’s effectiveness against SARS-CoV-2. Sound familiar? (will need boosters of this too presumably) |
| Anonymous Coward User ID: 75447494  United States01/17/2022 10:30 AM Report Abusive Post Report Copyright Violation | |
| Anonymous Coward User ID: 76796377 United States01/17/2022 10:30 AM Report Abusive Post Report Copyright Violation | |
| Reality Czar dodger007
User ID: 81769484 United States01/17/2022 10:30 AM  Report Abusive Post Report Copyright Violation | #BREAKING: Health Canada to authorize Pfizer's antiviral COVID-19 drug Quoting: Google_It [link to www.ctvnews.ca (secure)] OTTAWA -- Health Canada is expected to authorize the use of Pfizer’s COVID-19 antiviral treatment Paxlovid on Monday, CTV News has confirmed. The official announcement is expected to come from the federal health agency at 11 a.m. EST. Pfizer submitted clinical data for the oral medication that can be used to treat mild to moderate cases of COVID-19 in adults, on Dec. 1, 2021. The government has a deal in place with the pharmaceutical giant securing access to an initial one million doses of the therapeutic drug. Responding to recent calls from the provinces for a swift rollout of this medication in the face of an expected surge in Omicron hospitalizations, the federal government has vowed that delivery of the drug will happen in short order. ========================================================== Was there ever any doubt...? The question for me is this the pill with the microchip for complaince? Read the Mercola report, then decide The mechanism of this pill is to genetically change the virus cells What could possibly go wrong Just take a look at the 6 month studies Wait…there aren’t any Thread: UPDATE: FDA Approves TWO Outpatient Covid Treatments: Pills Marketed by Pfizer and Merck You can count on America to do the right thing after exhausting every other alternative." Winston Churchill |
| Reality Czar dodger007
User ID: 81769484 United States01/17/2022 10:43 AM Report Abusive Post Report Copyright Violation | In USA Highly conditional Authorized Emergency Use only - not Approval [link to www.covid19oralrx-patient.com (secure)] Authorized Use “The FDA has authorized the emergency use of PAXLOVID, an investigational medicine, for the treatment of mild-to-moderate COVID-19 in adults and children (12 years of age and older weighing at least 88 pounds [40 kg]) with a positive test for the virus that causes COVID-19, and who are at high risk for progression to severe COVID-19, including hospitalization or death, under an EUA. PAXLOVID is investigational because it is still being studied. There is limited information about the safety and effectiveness of using PAXLOVID to treat people with mild-to-moderate COVID-19.” You can count on America to do the right thing after exhausting every other alternative." Winston Churchill |
| Anonymous Coward User ID: 42528852 Canada01/17/2022 10:49 AM Report Abusive Post Report Copyright Violation | |
| Anonymous Coward User ID: 75447494 United States01/17/2022 10:53 AM Report Abusive Post Report Copyright Violation | |
| Google_It
(OP) User ID: 80175631 Canada01/17/2022 10:57 AM Report Abusive Post Report Copyright Violation | |
| Google_It
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