NEW: Ivermectin doesn’t prevent severe disease from Covid-19 any more effectively than a placebo, according to a new study published in JAMA

fake news

The antiparasitic drug ivermectin doesn't prevent severe disease from COVID-19 any more effectively than symptom management and close observation by medical professionals, according to a study published Friday in the journal JAMA Internal Medicine.

The study enrolled nearly 500 people 50 and older who were at risk of severe COVID-19 because of their age and underlying health. These patients were treated at 20 public hospitals and a quarantine center in Malaysia in 2021.

Half of the patients took a relatively high dose of oral ivermectin for five days, and the other half — the comparison group — received treatment for their symptoms, such as fever-reducing medications. All were monitored for progression of the disease.

There was no difference in outcomes between the groups. In fact, slightly more patients in the ivermectin group went on to need extra oxygen compared with those who took a placebo, though the difference was not statistically significant.

This was the main outcome researchers studied, but they also looked at whether patients needed to be hospitalized, had to go on a ventilator, needed intensive care or died from their infections.

There was no meaningful difference in outcomes between the group that took ivermectin and those who got the placebo treatment.

[link to www.wesh.com (secure)]

Hmmmm. It cured me. So.

Same. My wife and 2 kids also. My wife was in bad shape and 24 hours after IVMXN was better

fake news

Get fucked more than you already are, creep.

The antiparasitic drug ivermectin doesn't prevent severe disease from COVID-19 any more effectively than symptom management and close observation by medical professionals, according to a study published Friday in the journal JAMA Internal Medicine.

The study enrolled nearly 500 people 50 and older who were at risk of severe COVID-19 because of their age and underlying health. These patients were treated at 20 public hospitals and a quarantine center in Malaysia in 2021.

Half of the patients took a relatively high dose of oral ivermectin for five days, and the other half — the comparison group — received treatment for their symptoms, such as fever-reducing medications. All were monitored for progression of the disease.

There was no difference in outcomes between the groups. In fact, slightly more patients in the ivermectin group went on to need extra oxygen compared with those who took a placebo, though the difference was not statistically significant.

This was the main outcome researchers studied, but they also looked at whether patients needed to be hospitalized, had to go on a ventilator, needed intensive care or died from their infections.

There was no meaningful difference in outcomes between the group that took ivermectin and those who got the placebo treatment.

[link to www.wesh.com (secure)]

A whole city in Brazil was offered Ivermectin...

[link to www.cureus.com (secure)]
Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching
Published: January 15, 2022

(conducted between July 2020 and December 2020 in Itajaí, Brazil.)


Page 5: SUMMARY OF CITY-WIDE POPULATION USED FOR STUDY, EXCLUSIONS, INFECTION RATES.
[link to ibb.co (secure)]

Page 8: SUMMARY OF RESULTS: INFECTION, HOSPITALISATION, DEATH
[link to ibb.co (secure)]


Study interventions:
Ivermectin was offered as an optional treatment to be taken for two consecutive days every 15 days at a dose of 0.2 mg/kg/day.

In cases where a participating citizen of Itajaí became ill with COVID-19, they were recommended not to use ivermectin or any other medication in early outpatient treatment.


Method:
From the registry of the city population (223,128 inhabitants),
Subjects below 18 years old (61,583 subjects) were removed.
Of the 161,545 subjects above 18 years old from the city of Itajaí, we removed the 1,984 COVID-19 cases that occurred before July 7, 2020,
and 159,561 subjects remained.

Of the 223,128 citizens of Itajaí considered for the study, a total of 159,561 subjects were included in the analysis:
113,845 (71.3%) regular ivermectin users and 45,716 (23.3%) non-users.

Of these, 4,311 ivermectin users were infected, among which
4,197 were from the city of Itajaí (3.7% infection rate), and
3,034 non-users (from Itajaí) were infected (6.6% infection rate).
BOOM #1: 44% reduction in COVID-19 infection rate

--------- THEN, AMONGST THE INFECTED... ---------

Two cohorts of 3,034 subjects suffering from COVID-19 infection were compared.
- IMPORTANT: for every case in the "non-ivermectin" group, a corresponding case was found in the ivermectin users' group (matched age etc).


BOOM #2: regular use of ivermectin led to a 68% reduction in COVID-19 mortality
(25 [0.8%] versus 79 [2.6%] among ivermectin non-users)

BOOM #3: There was a 56% reduction in hospitalization rate
(44 versus 99 hospitalizations among ivermectin users and non-users, respectively.)

NOTE: the paricipants were ONLY using Ivermectin prophylactically, and advised to STOP taking it if they got COVID, yet the study STILL got the results above!


Housekeeping:
Hospitalization and mortality rates *before* matching groups &
the mortality rate in subpopulations *before* and *after* PSM [i.e. matching]
...are presented in the Appendix.

The study had several important strengths:

It was a randomized-controlled trial, the gold standard of medical research, in which researchers test an intervention against a placebo.

The study enrolled patients most likely to be at risk from severe COVID-19 disease: those over 50 with at least one additional risk factor and mild to moderate symptoms. People who had no symptoms or who had advanced disease were excluded.

Participants were enrolled only after a PCR test confirmed COVID-19 infection.
It was a multicenter trial conducted at 20 public hospitals and a COVID-19 quarantine center in Malaysia between May 31 and Oct. 25, 2021.

In addition to the fact that ivermectin didn't work, people who took it had more side effects than those who didn't, and sometimes those side effects were severe, including heart attacks, anemia and diarrhea that led to shock.

and, we're supposed to believe what they say?