Here's an update on recent findings regarding NAD+, resveratrol and NAC.

We knew the basic mechanics of how this was working, which is why the maintenance protocol doesn't contain oregano. We are now looking at updating the maintenance protocol to include resveratrol instead of an optional step. Here's why.

Resveratrol triggers SIRT1, which in turn triggers an adaptive immune response. This immune response includes production and enhancement of Th17 immune cells utilizing the IL-17 pathway. If you remember the original post, IL-17 dysfunction allows the fungus to survive in the body.

Resveratrol activates this needed pathway, and in combination with NAD+ it has everything it needs to activate the Th17 helper cells and they begin decimating the fungus residing in your mucous, including the interstitial. NAC is also partly responsible for this massive reaction as it boosts guanine levels which in combination with SIRT1 activation and IL-17 will go after the fungus directly in the mucous.

This process also activates master template gene transcription, and can fix many gene errors.

The NAC Protocol is absolutely essential before this process takes place. It allows the body to stop the inflammation loop from constant mycotoxin production, allows cell repair and tissue repair to return to normal, and sets the stage to turn on your immune response and target the fungus directly.

Resveratrol is a unique activator of SIRT1, as it has an anti inflammatory reaction. The other benefits of this final maintenance protocol are massively increased metabolism (weight loss), anti aging effects and DNA transcription repair. Using Resveratrol in combination with the maintenance protocol should be cycled. Run it for 3 to 4 weeks, then take a week off while continuing with black seed oil to inhibit biofilms and continually boost t cell counts.

I tried to simplify this as much as possible. It is a complex subject as human sirtuins (SIRT1) are still a new area of research and we've learned their power only recently.