Ivermectin worthless against COVID in largest clinical trial to date | |
Anonymous Coward (OP) User ID: 82627386 Netherlands 03/31/2022 10:42 PM Report Abusive Post Report Copyright Violation | "Abstract Background The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unclear. Methods We conducted a double-blind, randomized, placebo-controlled, adaptive platform trial involving symptomatic SARS-CoV-2–positive adults recruited from 12 public health clinics in Brazil. Patients who had had symptoms of Covid-19 for up to 7 days and had at least one risk factor for disease progression were randomly assigned to receive ivermectin (400 μg per kilogram of body weight) once daily for 3 days or placebo. (The trial also involved other interventions that are not reported here.) The primary composite outcome was hospitalization due to Covid-19 within 28 days after randomization or an emergency department visit due to clinical worsening of Covid-19 (defined as the participant remaining under observation for >6 hours) within 28 days after randomization. Results A total of 3515 patients were randomly assigned to receive ivermectin (679 patients), placebo (679), or another intervention (2157). Overall, 100 patients (14.7%) in the ivermectin group had a primary-outcome event, as compared with 111 (16.3%) in the placebo group (relative risk, 0.90; 95% Bayesian credible interval, 0.70 to 1.16). Of the 211 primary-outcome events, 171 (81.0%) were hospital admissions. Findings were similar to the primary analysis in a modified intention-to-treat analysis that included only patients who received at least one dose of ivermectin or placebo (relative risk, 0.89; 95% Bayesian credible interval, 0.69 to 1.15) and in a per-protocol analysis that included only patients who reported 100% adherence to the assigned regimen (relative risk, 0.94; 95% Bayesian credible interval, 0.67 to 1.35). There were no significant effects of ivermectin use on secondary outcomes or adverse events. Conclusions Treatment with ivermectin did not result in a lower incidence of medical admission to a hospital due to progression of Covid-19 or of prolonged emergency department observation among outpatients with an early diagnosis of Covid-19. (Funded by FastGrants and the Rainwater Charitable Foundation; TOGETHER ClinicalTrials.gov number, NCT04727424.)" |
pish
Turtle Hermit User ID: 80956893 United States 03/31/2022 10:44 PM Report Abusive Post Report Copyright Violation | Only because the internet said so. Were you there in the laboratory? Who funded the study? Are they biased? The internet is literally the “Great Delusion” spoke of in the Bible. Anything can the Truth, Fact, Hearsay, Lies, Opinion, and all of that combined.... You are submerged in a fake reality. Divers often die, because they can’t determine which way is up... This is what the internet is doing to you. Always remember these words: Work hard, study well, and eat and sleep plenty! That is the Turtle Hermit way! We must master the art of peace in addition to the art of war! |
Anonymous Coward User ID: 82380200 Nigeria 03/31/2022 10:45 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 81899863 United States 03/31/2022 10:46 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 70870847 United States 03/31/2022 10:47 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 82627386 Netherlands 03/31/2022 10:47 PM Report Abusive Post Report Copyright Violation | Wow - so you read the article and the study info. between the time of the first posting to this thread and the time you posted? OUTSTANDING. Not. A lot of skilled experts involved in that paper, I'll take their word over the fluff of a random Internet user. |
Anonymous Coward User ID: 82380200 Nigeria 03/31/2022 10:48 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 82627386 Netherlands 03/31/2022 10:48 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 82380200 Nigeria 03/31/2022 10:50 PM Report Abusive Post Report Copyright Violation | Wow - so you read the article and the study info. between the time of the first posting to this thread and the time you posted? OUTSTANDING. Not. A lot of skilled experts involved in that paper, I'll take their word over the fluff of a random Internet user. Dont take it then. Go get your 5th booster and wear 5 masks. Nobody gives a shit |
Anonymous Coward User ID: 82186701 United States 03/31/2022 10:50 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 80562286 United States 03/31/2022 10:51 PM Report Abusive Post Report Copyright Violation | Yes, this is true. These people stared at pictures of ivermectin for days and absolutely no change. They even set ivermectin on the counter and sat in front of it staring directly at it and no difference. Goes to show the horse paste is 100% worthless. |
Anonymous Coward (OP) User ID: 82627386 Netherlands 03/31/2022 10:52 PM Report Abusive Post Report Copyright Violation | Dont take it then. Go get your 5th booster and wear 5 masks. Nobody gives a shit Quoting: Anonymous Coward 82380200 Did you and the other trolls bother to read further about the study and the linked article? Of course not. "Nobody gives a shit" Huh? Too stupid to read and comprehend the linked article/paper is more like it. |
Anonymous Coward (OP) User ID: 82627386 Netherlands 03/31/2022 10:53 PM Report Abusive Post Report Copyright Violation | Yes, this is true. These people stared at pictures of ivermectin for days and absolutely no change. They even set ivermectin on the counter and sat in front of it staring directly at it and no difference. Goes to show the horse paste is 100% worthless. Quoting: Anonymous Coward 80562286 So that was your study? AMAZING. Big Gulps huh? cool. |
Anonymous Coward User ID: 82563204 03/31/2022 10:53 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 80290618 United States 03/31/2022 10:53 PM Report Abusive Post Report Copyright Violation | |
glp-smilies
User ID: 38128455 United States 03/31/2022 10:53 PM Report Abusive Post Report Copyright Violation | Sorry, we were told it KILLS people. The claim was that if people took it, they would die. That’s what the mainstream said. If it does nothing at all, then who cares?? From the very beginning, people were aware that it might not do anything, but they were also aware that there was no bad side effects either. But then the MSM decided to say it was dangerous and that doctors should lose their license for prescribing it. |
The Ocho
User ID: 81482289 United States 03/31/2022 10:55 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 82627386 Netherlands 03/31/2022 10:55 PM Report Abusive Post Report Copyright Violation | |
The Ocho
User ID: 81482289 United States 03/31/2022 10:56 PM Report Abusive Post Report Copyright Violation | |
The Tard Wrangler
User ID: 78388428 Australia 03/31/2022 10:56 PM Report Abusive Post Report Copyright Violation | Only because the internet said so. Quoting: pish Were you there in the laboratory? Who funded the study? Are they biased? The internet is literally the “Great Delusion” spoke of in the Bible. Anything can the Truth, Fact, Hearsay, Lies, Opinion, and all of that combined.... You are submerged in a fake reality. Divers often die, because they can’t determine which way is up... This is what the internet is doing to you. You don’t really believe that ivermectin has any usefulness in treating or preventing the corona AIDS, do you? Correcting the record one tard at a time #Junior Forum Mentor |
Anonymous Coward User ID: 82643602 03/31/2022 10:56 PM Report Abusive Post Report Copyright Violation | |
The Ocho
User ID: 81482289 United States 03/31/2022 10:56 PM Report Abusive Post Report Copyright Violation | |
pish
Turtle Hermit User ID: 80956893 United States 03/31/2022 10:57 PM Report Abusive Post Report Copyright Violation | Wow - so you read the article and the study info. between the time of the first posting to this thread and the time you posted? OUTSTANDING. Not. A lot of skilled experts involved in that paper, I'll take their word over the fluff of a random Internet user. I read it earlier. Not sure I believe their findings, and it was stand alone....we know Zinc needs to be involved in the equation for starters... Nobody will do an honest study using proven protocols... Ivermectin and other drugs...are cheap, and no money can be made by the pharma companies... So they will debunk. Aren’t they coming out with Covid pills? Imagine if they had “flu” pills all this time, but didn’t want to release them? Why cure the common cold if you sell billions of cold medicine every year? I learned long ago to supplement my health, so I don’t get thier yearly sickness... Always remember these words: Work hard, study well, and eat and sleep plenty! That is the Turtle Hermit way! We must master the art of peace in addition to the art of war! |
Anonymous Coward User ID: 82380200 Nigeria 03/31/2022 10:57 PM Report Abusive Post Report Copyright Violation | Dont take it then. Go get your 5th booster and wear 5 masks. Nobody gives a shit Quoting: Anonymous Coward 82380200 Did you and the other trolls bother to read further about the study and the linked article? Of course not. "Nobody gives a shit" Huh? Too stupid to read and comprehend the linked article/paper is more like it. How am I a troll? I dont need to read the fucking thing. I took it and it worked. Period |
A Concerned Denizen
User ID: 79546140 United States 03/31/2022 10:59 PM Report Abusive Post Report Copyright Violation | It should be noted that this study was for Invermectin only, and not with the protocol adding zinc, vit-c, vit-d, among other meds. Blab gobble doodle blurb! You disgusting Cretin! ~ Shit Puppet BrandAn is Nawt Mah Presdint -F J B Death to Ayatollah Ali Khamenei - Death to Iran Death to Kim Jong-un - Death to Democratic People's Republic of Best Korea Death to Xi Jinping - Death to People's Republic of China |
Anonymous Coward User ID: 82380200 Nigeria 03/31/2022 10:59 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 82672079 Australia 03/31/2022 11:02 PM Report Abusive Post Report Copyright Violation | The antiparasitic failed to reduce hospitalization and all other severe outcomes. Quoting: Anonymous Coward 82627386 "The largest clinical trial to date on the use of the antiparasitic drug ivermectin against COVID-19 concluded that the drug is completely ineffective at treating the pandemic disease, according to results published in The New England Journal of Medicine on Wednesday. The double-blind, randomized, placebo-controlled clinical trial was primarily designed to test if ivermectin could reduce the need for hospitalization among 1,358 COVID-19 patients at high risk of severe disease. Ivermectin did not, according to the international team of researchers behind the trial, dubbed TOGETHER. "We did not find a significantly or clinically meaningful lower risk of medical admission to a hospital or prolonged emergency department observation with ivermectin," the researchers reported. The folks with TOGETHER also found that the drug failed to reduce all other secondary outcomes of COVID-19, including the time to recovery, time to viral clearance on PCR test, time spent in the hospital, the need for mechanical ventilation, the duration of mechanical ventilation, death, or the time to death. "We found no important effects of treatment with ivermectin on the secondary outcomes," the researchers wrote." [link to arstechnica.com (secure)] [link to www.nejm.org (secure)] THIS IS A BOT^^^^^ |
Anonymous Coward User ID: 82622957 03/31/2022 11:04 PM Report Abusive Post Report Copyright Violation | |
Sharon Cherries
User ID: 81123363 United States 03/31/2022 11:07 PM Report Abusive Post Report Copyright Violation | |
The Tard Wrangler
User ID: 78388428 Australia 03/31/2022 11:07 PM Report Abusive Post Report Copyright Violation | Sorry, we were told it KILLS people. The claim was that if people took it, they would die. That’s what the mainstream said. If it does nothing at all, then who cares?? From the very beginning, people were aware that it might not do anything, but they were also aware that there was no bad side effects either. But then the MSM decided to say it was dangerous and that doctors should lose their license for prescribing it. Quoting: glp-smilies Complete bullshit. It was said, based on in vitro studies that you would need to take toxic amounts to have any benefit [link to ebm.bmj.com (secure)] “An important controversial point to consider in any rationale is the 5 µM required concentration to reach the anti-SARS-CoV-2 action of ivermectin observed in vitro,17 which is much higher than 0.28 µM, the maximum reported plasma concentration achieved in vivo with a dose of approximately 1700 µg/kg (about nine times the FDA-approved dosification).24 25 In this sense, basic fundamentals for assessing ivermectin in COVID-19 at a clinical level appear to be insufficient. Among other reasons, we believe this might have led WHO to exclude ivermectin from its Solidarity Trial for repurposed drugs for COVID-19,12 which raises questions about the pertinence of conducting clinical studies on ivermectin.” Correcting the record one tard at a time #Junior Forum Mentor |