Pfizer Responds!! | |
Happy in Nature
(OP) User ID: 84876380 Nicaragua 01/28/2023 01:57 AM Report Abusive Post Report Copyright Violation | Looks like a confession to me. If they were "original" viruses how did they become "variants of concern" ? [link to twitter.com (secure)] |
Happy in Nature
(OP) User ID: 84876380 Nicaragua 01/28/2023 01:58 AM Report Abusive Post Report Copyright Violation | “In a limited number of cases when a full virus does not contain any known gain of function mutations, such virus may be engineered to enable the assessment of antiviral activity in cells” - this implies they have worked on viruses that have had GoF. Is that new information?? [link to twitter.com (secure)] |
Anonymous Coward User ID: 77898421 United States 01/28/2023 02:01 AM Report Abusive Post Report Copyright Violation | New York, N.Y., January 27, 2023 – Allegations have recently been made related to gain of function and directed evolution research at Pfizer and the company would like to set the record straight. Quoting: Happy in Nature In the ongoing development of the Pfizer-BioNTech COVID-19 vaccine, Pfizer has not conducted gain of function or directed evolution research. Working with collaborators, we have conducted research where the original SARS-CoV-2 virus has been used to express the spike protein from new variants of concern. This work is undertaken once a new variant of concern has been identified by public health authorities. This research provides a way for us to rapidly assess the ability of an existing vaccine to induce antibodies that neutralize a newly identified variant of concern. We then make this data available through peer reviewed scientific journals and use it as one of the steps to determine whether a vaccine update is required. In addition, to meet U.S. and global regulatory requirements for our oral treatment, PAXLOVID™, Pfizer undertakes in vitro work (e.g., in a laboratory culture dish) to identify potential resistance mutations to nirmatrelvir, one of PAXLOVID’s two components. With a naturally evolving virus, it is important to routinely assess the activity of an antiviral. Most of this work is conducted using computer simulations or mutations of the main protease–a non-infectious part of the virus. In a limited number of cases when a full virus does not contain any known gain of function mutations, such virus may be engineered to enable the assessment of antiviral activity in cells. In addition, in vitro resistance selection experiments are undertaken in cells incubated with SARS-CoV-2 and nirmatrelvir in our secure Biosafety level 3 (BSL3) laboratory to assess whether the main protease can mutate to yield resistant strains of the virus. It is important to note that these studies are required by U.S. and global regulators for all antiviral products and are carried out by many companies and academic institutions in the U.S. and around the world. Fact-based information rooted in sound science is vitally important to overcoming the COVID-19 pandemic and Pfizer remains committed to transparency and helping alleviate the devastating burden of this disease. [link to www.pfizer.com (secure)] Scroll down to safety information and side effects that include myocarditis and pericarditis. Message to Pfizer: mess around and find out. |
Happy in Nature
(OP) User ID: 84876380 Nicaragua 01/28/2023 02:03 AM Report Abusive Post Report Copyright Violation | New York, N.Y., January 27, 2023 – Allegations have recently been made related to gain of function and directed evolution research at Pfizer and the company would like to set the record straight. Quoting: Happy in Nature In the ongoing development of the Pfizer-BioNTech COVID-19 vaccine, Pfizer has not conducted gain of function or directed evolution research. Working with collaborators, we have conducted research where the original SARS-CoV-2 virus has been used to express the spike protein from new variants of concern. This work is undertaken once a new variant of concern has been identified by public health authorities. This research provides a way for us to rapidly assess the ability of an existing vaccine to induce antibodies that neutralize a newly identified variant of concern. We then make this data available through peer reviewed scientific journals and use it as one of the steps to determine whether a vaccine update is required. In addition, to meet U.S. and global regulatory requirements for our oral treatment, PAXLOVID™, Pfizer undertakes in vitro work (e.g., in a laboratory culture dish) to identify potential resistance mutations to nirmatrelvir, one of PAXLOVID’s two components. With a naturally evolving virus, it is important to routinely assess the activity of an antiviral. Most of this work is conducted using computer simulations or mutations of the main protease–a non-infectious part of the virus. In a limited number of cases when a full virus does not contain any known gain of function mutations, such virus may be engineered to enable the assessment of antiviral activity in cells. In addition, in vitro resistance selection experiments are undertaken in cells incubated with SARS-CoV-2 and nirmatrelvir in our secure Biosafety level 3 (BSL3) laboratory to assess whether the main protease can mutate to yield resistant strains of the virus. It is important to note that these studies are required by U.S. and global regulators for all antiviral products and are carried out by many companies and academic institutions in the U.S. and around the world. Fact-based information rooted in sound science is vitally important to overcoming the COVID-19 pandemic and Pfizer remains committed to transparency and helping alleviate the devastating burden of this disease. [link to www.pfizer.com (secure)] Scroll down to safety information and side effects that include myocarditis and pericarditis. Message to Pfizer: mess around and find out. Read the comments in this tweet. Lots of vaxxed who are angry as hell. [link to twitter.com (secure)] |
led_Dis_Spencer
User ID: 67980327 United States 01/28/2023 02:03 AM Report Abusive Post Report Copyright Violation | |
Happy in Nature
(OP) User ID: 84876380 Nicaragua 01/28/2023 02:05 AM Report Abusive Post Report Copyright Violation | Directed evolution typically targets a particular gene for mutagenesis and then screens the resulting variants for a phenotype of interest, often independent of fitness effects, whereas adaptive laboratory evolution selects many genome-wide mutations [link to twitter.com (secure)] |
Anonymous Coward User ID: 85070979 United Kingdom 01/28/2023 02:06 AM Report Abusive Post Report Copyright Violation | |
led_Dis_Spencer
User ID: 67980327 United States 01/28/2023 02:09 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 85154411 United States 01/28/2023 02:23 AM Report Abusive Post Report Copyright Violation | New York, N.Y., January 27, 2023 – Allegations have recently been made related to gain of function and directed evolution research at Pfizer and the company would like to set the record straight. Quoting: Happy in Nature In the ongoing development of the Pfizer-BioNTech COVID-19 vaccine, Pfizer has not conducted gain of function or directed evolution research. Working with collaborators, we have conducted research where the original SARS-CoV-2 virus has been used to express the spike protein from new variants of concern. This work is undertaken once a new variant of concern has been identified by public health authorities. This research provides a way for us to rapidly assess the ability of an existing vaccine to induce antibodies that neutralize a newly identified variant of concern. We then make this data available through peer reviewed scientific journals and use it as one of the steps to determine whether a vaccine update is required. In addition, to meet U.S. and global regulatory requirements for our oral treatment, PAXLOVID™, Pfizer undertakes in vitro work (e.g., in a laboratory culture dish) to identify potential resistance mutations to nirmatrelvir, one of PAXLOVID’s two components. With a naturally evolving virus, it is important to routinely assess the activity of an antiviral. Most of this work is conducted using computer simulations or mutations of the main protease–a non-infectious part of the virus. In a limited number of cases when a full virus does not contain any known gain of function mutations, such virus may be engineered to enable the assessment of antiviral activity in cells. In addition, in vitro resistance selection experiments are undertaken in cells incubated with SARS-CoV-2 and nirmatrelvir in our secure Biosafety level 3 (BSL3) laboratory to assess whether the main protease can mutate to yield resistant strains of the virus. It is important to note that these studies are required by U.S. and global regulators for all antiviral products and are carried out by many companies and academic institutions in the U.S. and around the world. Fact-based information rooted in sound science is vitally important to overcoming the COVID-19 pandemic and Pfizer remains committed to transparency and helping alleviate the devastating burden of this disease. [link to www.pfizer.com (secure)] Scroll down to safety information and side effects that include myocarditis and pericarditis. Directed evolution…… |
Anonymous Coward User ID: 19145374 United States 01/28/2023 02:26 AM Report Abusive Post Report Copyright Violation | I don't know if they're lying but they definitely deny directed evolution research. The safety warnings are interesting. Let your "vaccination provider know if you have ever had myocarditis or pericarditis and You should not get COMIRNATY (COVID-19 Vaccine, mRNA), the Pfizer-BioNTech COVID-19 Vaccine, or the Pfizer-BioNTech COVID-19 Vaccine, Bivalent if you have had a severe allergic reaction after a previous dose of COMIRNATY or the Pfizer-BioNTech COVID-19 Vaccine or any ingredient in these vaccines. Hundreds of millions of people mandated, virtually ordered to get the injections never got these warnings! |
Anonymous Coward User ID: 80347842 United States 01/28/2023 02:26 AM Report Abusive Post Report Copyright Violation | New York, N.Y., January 27, 2023 – Allegations have recently been made related to gain of function and directed evolution research at Pfizer and the company would like to set the record straight. Quoting: Happy in Nature In the ongoing development of the Pfizer-BioNTech COVID-19 vaccine, Pfizer has not conducted gain of function or directed evolution research. Working with collaborators, we have conducted research where the original SARS-CoV-2 virus has been used to express the spike protein from new variants of concern. This work is undertaken once a new variant of concern has been identified by public health authorities. This research provides a way for us to rapidly assess the ability of an existing vaccine to induce antibodies that neutralize a newly identified variant of concern. We then make this data available through peer reviewed scientific journals and use it as one of the steps to determine whether a vaccine update is required. In addition, to meet U.S. and global regulatory requirements for our oral treatment, PAXLOVID™, Pfizer undertakes in vitro work (e.g., in a laboratory culture dish) to identify potential resistance mutations to nirmatrelvir, one of PAXLOVID’s two components. With a naturally evolving virus, it is important to routinely assess the activity of an antiviral. Most of this work is conducted using computer simulations or mutations of the main protease–a non-infectious part of the virus. In a limited number of cases when a full virus does not contain any known gain of function mutations, such virus may be engineered to enable the assessment of antiviral activity in cells. In addition, in vitro resistance selection experiments are undertaken in cells incubated with SARS-CoV-2 and nirmatrelvir in our secure Biosafety level 3 (BSL3) laboratory to assess whether the main protease can mutate to yield resistant strains of the virus. It is important to note that these studies are required by U.S. and global regulators for all antiviral products and are carried out by many companies and academic institutions in the U.S. and around the world. Fact-based information rooted in sound science is vitally important to overcoming the COVID-19 pandemic and Pfizer remains committed to transparency and helping alleviate the devastating burden of this disease. [link to www.pfizer.com (secure)] Scroll down to safety information and side effects that include myocarditis and pericarditis. Message to Pfizer: mess around and find out. My message to Pfizer: FUCK YOU!!! |
Anonymous Coward User ID: 19145374 United States 01/28/2023 02:27 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 85163682 Sweden 01/28/2023 02:28 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 73521963 United States 01/28/2023 02:29 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 85163682 Sweden 01/28/2023 02:29 AM Report Abusive Post Report Copyright Violation | |
A Deplorable Neanderthal
Forum Moderator User ID: 84800002 United Kingdom 01/28/2023 02:30 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 84525620 United States 01/28/2023 02:33 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 19145374 United States 01/28/2023 02:34 AM Report Abusive Post Report Copyright Violation | "...the original SARS-COV2 virus has been used to express...". Quoting: Anonymous Coward 85163682 It's official, their virus is their lab brew of poyzons, as they don't have a viable of the "virus" as a living species. Hihihih hahahah HHHHi HHHa HHHaH. Yeah, we know you're a big proponent of retarded terrain theory. |
led_Dis_Spencer
User ID: 67980327 United States 01/28/2023 02:36 AM Report Abusive Post Report Copyright Violation | Pfizer doing battle damage recovery.. Quoting: Anonymous Coward 84525620 If this death keeps up, none of them will be safe anywhere in the world.. can you copy and paste that again plox Gold is the money of kings. Silver is the money of gentlemen. Barter is the money of peasants. Debt is the money of slaves |
Anonymous Coward User ID: 76562429 Mexico 01/28/2023 02:39 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 19145374 United States 01/28/2023 02:39 AM Report Abusive Post Report Copyright Violation | Looks like a confession to me. If they were "original" viruses how did they become "variants of concern" ? Quoting: Happy in Nature [link to twitter.com (secure)] The coronavirus mutates on its own, doesn't need Pfizer's help. |
Anonymous Coward User ID: 85163682 Sweden 01/28/2023 02:43 AM Report Abusive Post Report Copyright Violation | |
led_Dis_Spencer
User ID: 67980327 United States 01/28/2023 02:48 AM Report Abusive Post Report Copyright Violation | Show me a viable sample of the "virus", ya retarded pfarma KUNT. Virology = ded. Long Live Humanity! correct they cant because its not alive, its a machine Gold is the money of kings. Silver is the money of gentlemen. Barter is the money of peasants. Debt is the money of slaves |
Happy in Nature
(OP) User ID: 84876380 Nicaragua 01/28/2023 02:54 AM Report Abusive Post Report Copyright Violation | My reading is #Pfizer have had contract researchers take the original virus strain (the really deadly one) and substitute out the original spike protein for spikes from newer, more infectious variants. (= deadly and more infectious?!) Looks like gain of function research to me. [link to twitter.com (secure)] |
Anonymous Coward User ID: 77994864 United States 01/28/2023 02:54 AM Report Abusive Post Report Copyright Violation | Yall vax lovers got the Vaids now and Antibody Dependent Enhancement will destroy your natural immunity over time. You will die MUCH younger than you would have. The more boosters of mRNA therapy you've received, the greater & swifter the impact will be. See ya in 2025, or not. |
Anonymous Coward User ID: 85163763 Romania 01/28/2023 02:54 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 74024733 United States 01/28/2023 02:58 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 84950558 Romania 01/28/2023 02:58 AM Report Abusive Post Report Copyright Violation | |
Happy in Nature
(OP) User ID: 84876380 Nicaragua 01/28/2023 03:00 AM Report Abusive Post Report Copyright Violation | 1. When I worked at Bayer, they got around regulations on "genetically modified" pesticide biologics by performing so-called "encouraged evolution" to achieve a desired mutation. Similar to how Pfizer is performing "directed evolution" to avoid calling it "gain of function." 2. But these "encouraged" or "directed" "evolution" methods are actually more dangerous than straightforward genetic modification, because the mutations are not precisely targeted. They mutate the ENTIRE genomes with mutagens and what they produce is much more unpredictable. 3. These "evolutionary" methods to create mutants are not done because they're less dangerous to humans. It's done because it's less LEGALLY dangerous, has fewer costly regulations to circumvent, and has less social stigma associated with it. That's all. 4. This was always fully acknowledged within the company. Meanwhile the Left-wing protesters went and protested Monsanto down the street because they were producing evil "genetically modified" plants and pesticides, while we were spared because we did "encouraged evolution." [link to twitter.com (secure)] https://twitter.com/_/status/1618493887961763840 |
led_Dis_Spencer
User ID: 67980327 United States 01/28/2023 03:03 AM Report Abusive Post Report Copyright Violation | September Rain Last Edited by led_Dis_Spencer on 01/28/2023 03:27 AM Gold is the money of kings. Silver is the money of gentlemen. Barter is the money of peasants. Debt is the money of slaves |