Flu vaccine production hits snag. | |
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(OP) User ID: 599165 United Kingdom 07/13/2009 06:58 AM Report Abusive Post Report Copyright Violation | Most producers (at least Bater here in Europe) are not using egg for the vaccine but duplicating it through cell culture. Quoting: Anonymous Coward 724536If one method hits snags then there will be more through the other method. Apparently very few producers use cell culture and most use4 eggs. The WHO is expected to reveal details of the expert panel's deliberations and recommendations today. But a report to the meeting by Dr. Wenqing Zhang of the WHO's global influenza program says vaccine manufacturers who use so-called wild-type viruses (unmodified viruses like those now circulating around the globe) are reporting yield rates similar to what they get when they grow seasonal flu viruses in Vero cells, a cell culture medium. However, few manufacturers produce flu vaccine this way. Most make vaccine in eggs, using a reassortant or hybrid seed strain designed to improve the chances of a good yield. A hybrid has the external genes of the virus that vaccine is to protect against and the internal genes of a virus with a proven track record for growing well. Zhang's presentation says that of the various reassortant vaccine viruses that have been made, the one with the highest output still only generates about half of the yield seen with seasonal flu vaccine production. |
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(OP) User ID: 599165 United Kingdom 07/13/2009 01:02 PM Report Abusive Post Report Copyright Violation | UPDATE LONDON – A fully licensed swine flu vaccine might not be available until the end of the year, a top official at the World Health Organization said Monday, in a report that could affect many countries' vaccination plans. But countries could use emergency provisions to get the vaccines out quicker if they decide their populations need them, Marie-Paule Kieny, director of WHO's Initiative for Vaccine Research, said during a news conference. The swine flu viruses currently being used to develop a vaccine aren't producing enough of the ingredient needed for the vaccine, and WHO has asked its laboratory network to produce a new set of viruses as soon as possible. [link to news.yahoo.com] |
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