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Flu vaccine production hits snag.

 
Nightshade
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User ID: 599165
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07/13/2009 05:50 AM
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Flu vaccine production hits snag.
It looks like it might quite a while before there is enough vaccine for all of us. Excellent! maybe they won't hunt us down and make us get it as they will be struggling providing for those who do.


H1N1 vaccine hits snag with production 'less than optimal'

July 13, 2009
HELEN BRANSWELL
THE CANADIAN PRESS
Production of a vaccine for the H1N1 flu virus has hit a snag, with manufacturers reporting a disappointingly low yield when viruses are grown in eggs.

The World Health Organization says so far the yield for egg-based production is half or less what manufacturers get when they make vaccine to protect against seasonal flu viruses.

New seed strains are being made in the hopes of increasing the vaccine yield, says a report by the WHO's vaccine chief, Dr. Marie-Paule Kieny.

But if the yield cannot be increased, it will slow the rate at which pandemic vaccine comes out of the production pipeline, adding to the time it takes to protect populations in countries like Canada that have purchased vaccine. And countries that haven't pre-ordered pandemic vaccine would face substantial delays before manufacturers have product to sell to them.

"There's nothing to suggest it will take longer to make vaccine, if in fact everything goes as planned. The question is: How much?'' says Dr. Michael Osterholm, director of the Center for Infectious Diseases Research and Policy at the University of Minnesota.

[link to news.therecord.com]
Anonymous Coward
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07/13/2009 05:54 AM
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Re: Flu vaccine production hits snag.
bump Not to worry the world would probly be heathier without it any way!!!
Anonymous Coward
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Canada
07/13/2009 06:22 AM
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Re: Flu vaccine production hits snag.
bump 5a
Anonymous Coward
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India
07/13/2009 06:25 AM
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Re: Flu vaccine production hits snag.
More info here : Thread: BREAKING : Mandatory Swine Flu vaccination globally likely by next week
Anonymous Coward
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Austria
07/13/2009 06:52 AM
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Re: Flu vaccine production hits snag.
Most producers (at least Bater here in Europe) are not using egg for the vaccine but duplicating it through cell culture.

If one method hits snags then there will be more through the other method.
Anonymous Coward
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Austria
07/13/2009 06:53 AM
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Re: Flu vaccine production hits snag.
Baxter not bater
Anonymous Coward
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United States
07/13/2009 06:54 AM
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Re: Flu vaccine production hits snag.
Good. Gives me more time to prepare.
Nightshade  (OP)

User ID: 599165
United Kingdom
07/13/2009 06:58 AM
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Re: Flu vaccine production hits snag.
Most producers (at least Bater here in Europe) are not using egg for the vaccine but duplicating it through cell culture.

If one method hits snags then there will be more through the other method.
 Quoting: Anonymous Coward 724536


Apparently very few producers use cell culture and most use4 eggs.

The WHO is expected to reveal details of the expert panel's deliberations and recommendations today.

But a report to the meeting by Dr. Wenqing Zhang of the WHO's global influenza program says vaccine manufacturers who use so-called wild-type viruses (unmodified viruses like those now circulating around the globe) are reporting yield rates similar to what they get when they grow seasonal flu viruses in Vero cells, a cell culture medium. However, few manufacturers produce flu vaccine this way.

Most make vaccine in eggs, using a reassortant or hybrid seed strain designed to improve the chances of a good yield. A hybrid has the external genes of the virus that vaccine is to protect against and the internal genes of a virus with a proven track record for growing well.

Zhang's presentation says that of the various reassortant vaccine viruses that have been made, the one with the highest output still only generates about half of the yield seen with seasonal flu vaccine production.
Nightshade  (OP)

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07/13/2009 01:02 PM
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Re: Flu vaccine production hits snag.
UPDATE


LONDON – A fully licensed swine flu vaccine might not be available until the end of the year, a top official at the World Health Organization said Monday, in a report that could affect many countries' vaccination plans.
But countries could use emergency provisions to get the vaccines out quicker if they decide their populations need them, Marie-Paule Kieny, director of WHO's Initiative for Vaccine Research, said during a news conference.
The swine flu viruses currently being used to develop a vaccine aren't producing enough of the ingredient needed for the vaccine, and WHO has asked its laboratory network to produce a new set of viruses as soon as possible.

[link to news.yahoo.com]
Anonymous Coward
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07/13/2009 01:14 PM
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Re: Flu vaccine production hits snag.
Interesting...wonder if they will use this as an excuse to use even MORE experimental methods though.
Anonymous Coward
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07/13/2009 01:51 PM
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Re: Flu vaccine production hits snag.
Or the virus is mutating so rapidly that each batch is useless...
Anonymous Coward
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United States
07/13/2009 02:00 PM
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Re: Flu vaccine production hits snag.
TOTAL WAST OF TIME.and who get the contract for all the vacines?AND MONEY...mutation..haa disinformation,they want you to be afraid of it!

Why don't they come up with a cure for themselfs!
Nightshade  (OP)

User ID: 599165
United Kingdom
07/13/2009 05:30 PM
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Re: Flu vaccine production hits snag.
Bump for people worried that the vaccines will be enforced soon.





GLP