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Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked

 
Lex Talionis
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Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
BACKGROUND:

Ebola virus is one of the most virulent pathogens, killing a very high proportion of patients within 5-7 days. Two outbreaks of fulminating haemorrhagic fever occurred in northern Gabon in 1996, with a 70% case-fatality rate. During both outbreaks we identified some individuals in direct contact with sick patients who never developed symptoms. We aimed to determine whether these individuals were indeed infected with Ebola virus, and how they maintained asymptomatic status.

INTERPRETATION:

This study showed that asymptomatic, replicative Ebola infection can and does occur in human beings. The lack of genetic differences between symptomatic and asymptomatic individuals suggest that asymptomatic Ebola infection did not result from viral mutations. Elucidation of the factors related to the genesis of the strong inflammatory response occurring early during the infectious process in these asymptomatic individuals could increase our understanding of the disease.



[link to www.ncbi.nlm.nih.gov]
"Tolerance is the lube that helps slip the dildo of dysfunction into the ass of a civilized society." Plato
Anonymous Coward
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
Typhoid Mary. Ebola Joe.
Lex Talionis  (OP)

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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
Can you say "Carrier"?
"Tolerance is the lube that helps slip the dildo of dysfunction into the ass of a civilized society." Plato
Lex Talionis  (OP)

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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
New study reveals that up to 12% of Ebola cases are asymptomatic past 21 days

Learn more: [link to www.naturalnews.com]
"Tolerance is the lube that helps slip the dildo of dysfunction into the ass of a civilized society." Plato
Lex Talionis  (OP)

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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
"So how could all the people who spent days in close quarters with a man sickened with Ebola manage to evade illness?

One possible explanation that has rarely been discussed is that people could be infected with Ebola without ever showing symptoms. The phenomenon is called "asymptomatic infection," and it is an unusual but potentially very real feature of the Ebola virus in humans."

[link to www.washingtonpost.com]
"Tolerance is the lube that helps slip the dildo of dysfunction into the ass of a civilized society." Plato
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
If you won't make time for the entire speech, scroll to the 16 minute mark.

Lex Talionis  (OP)

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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
Ebola victims without symptoms can still be contagious
German doctors show CDC wrong about spread of disease


Read more at [link to www.wnd.com]
"Tolerance is the lube that helps slip the dildo of dysfunction into the ass of a civilized society." Plato
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10/17/2014 09:57 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
New study reveals that up to 12% of Ebola cases are asymptomatic past 21 days

Learn more: [link to www.naturalnews.com]
 Quoting: Lex Talionis


oh, fuck.

holy fuck, that's over DOUBLE what the CDC says.
Lex Talionis  (OP)

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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
If you won't make time for the entire speech, scroll to the 16 minute mark.


 Quoting: Anonymous Coward 58956280


Excellent video AC.

Thank you.
"Tolerance is the lube that helps slip the dildo of dysfunction into the ass of a civilized society." Plato
Lex Talionis  (OP)

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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
People Carrying Ebola, in Some Cases, May Be Free of Symptoms

[link to www.nytimes.com]
"Tolerance is the lube that helps slip the dildo of dysfunction into the ass of a civilized society." Plato
Anonymous Coward
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
This is a three-stage bioweapon.

The first stage (the one we're experiencing now) has low immediate lethality, but it primes the population with asymptomatic Ebola.

In the second stage, another variation of the virus is released. It's more lethal in itself, but it also activates the symptoms of the first stage virus.

There will also be a third stage release that will be genetically modified to target those who exhibited natural immunity to the first two variants.
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
oooowe'rewalkingdead
Lex Talionis  (OP)

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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
The Ebola Epidemic Is About to Get Worse. Much Worse.

As in: We need to order 500 million vaccines. Now.

Read more: [link to www.politico.com]
"Tolerance is the lube that helps slip the dildo of dysfunction into the ass of a civilized society." Plato
Anonymous Coward
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10/17/2014 10:19 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
This is a three-stage bioweapon.

The first stage (the one we're experiencing now) has low immediate lethality, but it primes the population with asymptomatic Ebola.

In the second stage, another variation of the virus is released. It's more lethal in itself, but it also activates the symptoms of the first stage virus.

There will also be a third stage release that will be genetically modified to target those who exhibited natural immunity to the first two variants.
 Quoting: Anonymous Coward 61310831



this sounds plausible, but what's your source?

do you have any more info?
Are we going to see a 70% death rate or higher?
Anonymous Coward
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10/17/2014 10:19 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
This is the Dawn of the Dead!
It was a sad and beautiful world. ... .
Anonymous Coward
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10/17/2014 10:27 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
If you won't make time for the entire speech, scroll to the 16 minute mark.


 Quoting: Anonymous Coward 58956280


Excellent video AC.

Thank you.
 Quoting: Lex Talionis


You're quite welcome. I wish more people would watch it. BTW Osterholm claims we are nowhere near a proper vaccine yet. I'm no vaccine fan but might consider it when HE'S satisfied, but not until then.
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10/17/2014 10:29 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
If you won't make time for the entire speech, scroll to the 16 minute mark.


 Quoting: Anonymous Coward 58956280



This video is really REALLY helpful.
Anonymous Coward
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10/17/2014 10:34 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
Typhoid Mary. Ebola Joe.
 Quoting: Anonymous Coward 64179147


Barack Hussein Obola!

ohappy
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10/17/2014 11:10 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
If you won't make time for the entire speech, scroll to the 16 minute mark.


 Quoting: Anonymous Coward 58956280


We are always couching things in certainty for which certainty does not exist

Yes, and we readily accept this delusion because WE WANT TO BELIEVE IT.

.
neodimiun

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10/17/2014 11:15 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
BACKGROUND:

Ebola virus is one of the most virulent pathogens, killing a very high proportion of patients within 5-7 days. Two outbreaks of fulminating haemorrhagic fever occurred in northern Gabon in 1996, with a 70% case-fatality rate. During both outbreaks we identified some individuals in direct contact with sick patients who never developed symptoms. We aimed to determine whether these individuals were indeed infected with Ebola virus, and how they maintained asymptomatic status.

INTERPRETATION:

This study showed that asymptomatic, replicative Ebola infection can and does occur in human beings. The lack of genetic differences between symptomatic and asymptomatic individuals suggest that asymptomatic Ebola infection did not result from viral mutations. Elucidation of the factors related to the genesis of the strong inflammatory response occurring early during the infectious process in these asymptomatic individuals could increase our understanding of the disease.



[link to www.ncbi.nlm.nih.gov]
 Quoting: Lex Talionis


Here is the full article

[link to www.thelancet.com]

Published on 24 June 2000, we have to see if there are followup studies to this.
A person who never made a mistake never tried anything new.
Albert Einstein
neodimiun

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10/17/2014 11:21 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
From the discussion of the article:

"These findings show that some individuals were infected with the virus without developing symptoms. Results from previous outbreaks had only indicated that such an asymptomatic infection was possible. During the first three outbreaks of Ebola virus in Sudan and Zaire in 1976 and 1979, WHO teams noticed that individuals had symptoms that ranged in severity, from mild (and probably asymptomatic) to rapidly fatal"

"From the beginning to the end of both outbreaks, we identified 24 individuals who were directly exposed to infected materials from fatal and non-fatal cases, but who did not develop symptoms. These individuals were family members of symptomatic patients who lived continuously with them, and took care of them without any physical protection such as gloves. Throughout the study, these individuals were sampled several times, from the time of first exposure to a sick patient. We report a description of asymptomatic and replicative Ebola infection in human beings."

In other words, people could be walking around spreading Ebola and showing no signs of infection...

Last Edited by neodimiun on 10/17/2014 11:24 AM
A person who never made a mistake never tried anything new.
Albert Einstein
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
Good post thanks
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10/17/2014 11:25 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
I love seeing all these long GLP timers posting threads interesting to see who is out theregrouphug
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
If you won't make time for the entire speech, scroll to the 16 minute mark.


 Quoting: Anonymous Coward 58956280


Direct quote of the Director of CIDRAP:
"I think it is a travesty we are now into this outbreak so far and we have a SINGLE SET of viral isolates with genomic data from one location in Sierra Leone from May, and we got people making pronouncements about what this virus is doing; they don't know what the hell they are talking about. They don't know what's going on. "
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
If you won't make time for the entire speech, scroll to the 16 minute mark.


 Quoting: Anonymous Coward 58956280


Direct quote of the Director of CIDRAP:
"I think it is a travesty we are now into this outbreak so far and we have a SINGLE SET of viral isolates with genomic data from one location in Sierra Leone from May, and we got people making pronouncements about what this virus is doing; they don't know what the hell they are talking about. They don't know what's going on. "
 Quoting: Anonymous Coward 64179147


edit to add, that ^^^^^^ is at 14m 20s..
neodimiun

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10/17/2014 11:33 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
BACKGROUND:

Ebola virus is one of the most virulent pathogens, killing a very high proportion of patients within 5-7 days. Two outbreaks of fulminating haemorrhagic fever occurred in northern Gabon in 1996, with a 70% case-fatality rate. During both outbreaks we identified some individuals in direct contact with sick patients who never developed symptoms. We aimed to determine whether these individuals were indeed infected with Ebola virus, and how they maintained asymptomatic status.

INTERPRETATION:

This study showed that asymptomatic, replicative Ebola infection can and does occur in human beings. The lack of genetic differences between symptomatic and asymptomatic individuals suggest that asymptomatic Ebola infection did not result from viral mutations. Elucidation of the factors related to the genesis of the strong inflammatory response occurring early during the infectious process in these asymptomatic individuals could increase our understanding of the disease.



[link to www.ncbi.nlm.nih.gov]
 Quoting: Lex Talionis


Here is the full article

[link to www.thelancet.com]

Published on 24 June 2000, we have to see if there are followup studies to this.
 Quoting: neodimiun



HOLY SHIT!! Found a more recent study on Ebola by the same author (E. M. Leroy). Published on 26 SEP 2014
Titled: Ebola in West Africa: the outbreak able to change many things

"In its own reservoir, EBOV replicates very slowly in target organs such as the liver and spleen; viral load is often undetectable, and the animal does not usually show any symptoms. The genomic evolution of genomic evolution of EBOV is therefore very slow. In humans, the situation is completely reversed. Indeed, EBOV finds a favourable environment for replication, and can reach extremely high viral loads (up to 109 particles/mL of blood). The high viral multiplication rate increases the probability of mutation.

"...All of these factors could finally induce phenotypic modifications in virulence or transmission mode in humans; airborne or vector-borne transmission could have catastrophic effects."

[link to onlinelibrary.wiley.com]

So in humans it mutates faster...so fast that it could indeed become airbone...
Guys you need to check this out!
bumpbumpbump

Last Edited by neodimiun on 10/17/2014 11:43 AM
A person who never made a mistake never tried anything new.
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Tidette

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10/17/2014 11:35 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
I think Red Eye Rick must be carrier, he and couple others not giving blood. Yet they robbing Brantley of his weekly.
Tidette
Lex
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10/17/2014 11:40 AM
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
In the Walking Dead, didn't they mention at one point that everyone had it? The CDC episode or near it.
OilMan

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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
Great information!
bump and 5. *
OilMan
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
I am not a nurse but have been saying this same thing! I truly believe we simply do not know anything to be certain. I think there are a huge number of variables in this thing- longer incubations, different symptoms, one symptom, 5 symptoms, no symptoms. If those nurses who were considered low risk are sick, and are sick now... What about the health care workers who were deemed high risk? Not hearing about them or anyone else, are we. Or Duncan's family... It's like they suddenly fell off the face of the earth.
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Re: Asymptomatic, replicative Ebola infection can and does occur in human beings. ie We're all fucked
:wedead:





GLP