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Researchers are working on a vaccine that could prevent Alzheimer's disease

 
Reality420
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06/11/2019 05:08 PM
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Researchers are working on a vaccine that could prevent Alzheimer's disease
One of the physical manifestations of Alzheimer's is the accumulation and "tangling" of a protein called Tau in neurons.
Researchers at UNM are researching a vaccine that could, eventually, prevent Alzheimer's disease by attacking these "tangles".
The vaccine involves VLPs (virus-like particles) that eliminated the Tau tangles in mice.
The article(s) also states the "vaccine that could prevent the formation of the tau tangles" and thus be preventive.
The mice who were treated showed marked improvement in cognitive abilities compared to those untreated.
.
This is very interesting particularly for anyone who has seen Alzheimer's patients.
The problem is that murine studies have a long history of failure upon ramping up to human studies. IIRC the rate is something like 1-2% of murine studies translate to humans well.
So don't get your hopes up too high, but this is still hopeful.
.
University of New Mexico news release:
[link to hscnews.unm.edu]

Video report for the reading impaired:
[link to www.cbsnews.com (secure)]
.
Ain't science wunnerful?
Hopefully the researcher working on Alzheimer's will find a solution to this devastating and heartbreaking disease.

Keep up the hope and...
Have fun.


R.
Ridicule is the only weapon which can be used against unintelligible propositions.
— Thomas Jefferson

Nothing is more terrible than to see ignorance in action.
— Johann Wolfgang von Goethe
Anonymous Coward
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06/11/2019 05:12 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
How Ironic.

Vaccines: Autism in the Young, Alzheimer's/Dementia in Adults.

And around and around we go...
The_Meridian
Breshears is Off: Ask Me Why

User ID: 76838634
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06/11/2019 05:17 PM

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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
Get rid of aluminum and mercury in your body and you'll be fine.
(B)ullshit™ always needs an amplified bullhorn demanding kneeling subservience - or else.- SyncAsFunk

The light within me always draws me back to make the dark decision to leave the false counterfeit light. -New Heart
Formally CannabisUser1111111
User ID: 75555655
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06/11/2019 06:25 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
One of the physical manifestations of Alzheimer's is the accumulation and "tangling" of a protein called Tau in neurons.
Researchers at UNM are researching a vaccine that could, eventually, prevent Alzheimer's disease by attacking these "tangles".
The vaccine involves VLPs (virus-like particles) that eliminated the Tau tangles in mice.
The article(s) also states the "vaccine that could prevent the formation of the tau tangles" and thus be preventive.
The mice who were treated showed marked improvement in cognitive abilities compared to those untreated.
.
This is very interesting particularly for anyone who has seen Alzheimer's patients.
The problem is that murine studies have a long history of failure upon ramping up to human studies. IIRC the rate is something like 1-2% of murine studies translate to humans well.
So don't get your hopes up too high, but this is still hopeful.
.
University of New Mexico news release:
[link to hscnews.unm.edu]

Video report for the reading impaired:
[link to www.cbsnews.com (secure)]
.
Ain't science wunnerful?
Hopefully the researcher working on Alzheimer's will find a solution to this devastating and heartbreaking disease.

Keep up the hope and...
Have fun.


R.
 Quoting: Reality420


Should have stuck with what they already know about the compounds found in most strains of cannabis. Eedjots.
Reality420  (OP)

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06/11/2019 08:01 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
How Ironic.
Vaccines: Autism in the Young, Alzheimer's/Dementia in Adults.
And around and around we go...
 Quoting: Anonymous Coward 6655394


You're right.
There is a current vaccine to prevent one known cause of autism that is given to the young.
Can you guess which one?
.
And now they are working on a vaccine to prevent one of the causes of Alzheimer's.

Ain't science wonderful?


R.
Ridicule is the only weapon which can be used against unintelligible propositions.
— Thomas Jefferson

Nothing is more terrible than to see ignorance in action.
— Johann Wolfgang von Goethe
Jake

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06/11/2019 08:03 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
if it is a vaccine they know its caused by an infection.

Last Edited by Slowly awakening on 06/11/2019 08:04 PM
Evil controls the ignorant... Climate change is a hoax so is the vax you have been fear-porned into compliance!

Definition Satan from the bible: Satan (Rev 12:7) exercising his subtle (indirect) impact on heathen governments (powers) – i.e. accomplishing his hellish agenda from "behind the scenes."
Anonymous Coward
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06/11/2019 08:45 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
here is the kicker...they give it to mice, to test their various strategies to retard its development,... how do they know which virus to isolate to infect them mice? how does one create a vaccine to target a mutable virus?...
Fractals

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06/11/2019 08:47 PM

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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
That shit is awful. Grandad died of that and a variety of other ailments. Used to hallucinate often. He complained of a pink mouse on a bicycle riding around his living room often
Reality420  (OP)

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06/11/2019 08:48 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
if it is a vaccine they know its caused by an infection.
 Quoting: Jake


That isn't how the immune system works.
The immune system is working even in the absence of an infection by an outside agent. Think about cancer...
You are constantly developing cancerous/mutated cells that the immune system recognizes as imperfect and foreign and destroys - no outside agent required.
.
This vaccine is basically a protein shell with some of the proteins/peptides of the Tau protein expressed (attached) on the surface which are then recognized as "invaders" stimulating the immune system to destroy the Tau proteins.
.
Whether this will work in humans remains to be seen.


R.
Ridicule is the only weapon which can be used against unintelligible propositions.
— Thomas Jefferson

Nothing is more terrible than to see ignorance in action.
— Johann Wolfgang von Goethe
Reality420  (OP)

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06/11/2019 08:51 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
here is the kicker...they give it to mice, to test their various strategies to retard its development,... how do they know which virus to isolate to infect them mice? how does one create a vaccine to target a mutable virus?...
 Quoting: Anonymous Coward 77722150


They aren't targeting a virus, they are targeting the Tau proteins.
They are using the "dead" shell of a virus to stimulate the immune system to sense and defend against the Tau protein fragments the scientists have attached to this shell.


R.
Ridicule is the only weapon which can be used against unintelligible propositions.
— Thomas Jefferson

Nothing is more terrible than to see ignorance in action.
— Johann Wolfgang von Goethe
Reality420  (OP)

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06/11/2019 08:53 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
That shit is awful. Grandad died of that and a variety of other ailments. Used to hallucinate often. He complained of a pink mouse on a bicycle riding around his living room often
 Quoting: Fractals


Yes it is.
My sil's father had Alzheimer's and it was tragic and heartbreaking. He was my friend since my brother married his daughter.


R.
Ridicule is the only weapon which can be used against unintelligible propositions.
— Thomas Jefferson

Nothing is more terrible than to see ignorance in action.
— Johann Wolfgang von Goethe
Jake

User ID: 76890717
United States
06/11/2019 08:55 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
if it is a vaccine they know its caused by an infection.
 Quoting: Jake


That isn't how the immune system works.
The immune system is working even in the absence of an infection by an outside agent. Think about cancer...
You are constantly developing cancerous/mutated cells that the immune system recognizes as imperfect and foreign and destroys - no outside agent required.
.
This vaccine is basically a protein shell with some of the proteins/peptides of the Tau protein expressed (attached) on the surface which are then recognized as "invaders" stimulating the immune system to destroy the Tau proteins.
.
Whether this will work in humans remains to be seen.


R.
 Quoting: Reality420


yes they are called antigens and bacteria also create antigens.

It has been suspected for a long time that there is

bacterial involvement in alzheimer's.


You can create an immune boosting autogenous vaccine but

that would be too expensive as it would be on a case by case basis.


My guess is they know what causes Alzheimer's and it is

either a bacteria, Virus, or prion





Thread: We may finally know what causes Alzheimer’s – and how to stop it
Evil controls the ignorant... Climate change is a hoax so is the vax you have been fear-porned into compliance!

Definition Satan from the bible: Satan (Rev 12:7) exercising his subtle (indirect) impact on heathen governments (powers) – i.e. accomplishing his hellish agenda from "behind the scenes."
Anonymous Coward
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06/11/2019 09:32 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
here is the kicker...they give it to mice, to test their various strategies to retard its development,... how do they know which virus to isolate to infect them mice? how does one create a vaccine to target a mutable virus?...
 Quoting: Anonymous Coward 77722150


They aren't targeting a virus, they are targeting the Tau proteins.
They are using the "dead" shell of a virus to stimulate the immune system to sense and defend against the Tau protein fragments the scientists have attached to this shell.


R.
 Quoting: Reality420


thanks for the clarification, i get you, its a fascinating topic, also close to home, grand parents lost to it, caring for my ma as she succumbs to it, those taus are funny little things, it is interesting to note that phosphorous in excess leads to tau accumulation
Anonymous Coward
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06/11/2019 09:34 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
it appears that work on enzymes specifically ketases would be a better place to start??
beeches

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06/11/2019 09:36 PM

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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
if it is a vaccine they know its caused by an infection.
 Quoting: Jake


this

the drug Embrel supposedly dropped the Alzheimers rate by 60% in the people taking it for rheumatoid arthritis and other inflammatory conditions


was a thread recently
Liberalism is totalitarianism with a human face – Thomas Sowell
Anonymous Coward
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06/11/2019 09:37 PM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
it appears that work on enzymes specifically ketases would be a better place to start??
 Quoting: Anonymous Coward 77722150


kinases not ketases lol must be catching a bit of it myself
right?

User ID: 64900583
United States
08/27/2022 08:38 AM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
How Ironic.
Vaccines: Autism in the Young, Alzheimer's/Dementia in Adults.
And around and around we go...
 Quoting: Anonymous Coward 6655394


You're right.
There is a current vaccine to prevent one known cause of autism that is given to the young.
Can you guess which one?
.
And now they are working on a vaccine to prevent one of the causes of Alzheimer's.

Ain't science wonderful?


R.
 Quoting: Reality420


I wonder if it will be an experimental type RNA vaccine. They are HUGE profit makers for those companies. Adjuvants **aluminum** IN THE VACCINES biopersistence in brain tissue. [link to pubmed.ncbi.nlm.nih.gov (secure)]

What is the role of "tangles" *** Neurofibrillary tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary biomarker of Alzheimer's disease. Their presence is also found in numerous other diseases known as tauopathies. Little is known about their exact relationship to the different pathologies.

Harmful or protective?
There has been some suggestion that the formation of NFTs does not have a causal relationship with disease. Rather that NFTs may be produced in response to a variety of conditions and may in fact be a compensatory response against oxidative stress and serves a protective function.

[link to en.wikipedia.org (secure)]
Anonymous Coward
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08/27/2022 08:44 AM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
Its called TURMERIC it dissolves amyloids. Bit yeah poison your blood with synthetic poison if you must.
Anonymous Coward
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Germany
08/27/2022 08:45 AM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
Keeping your insulin down prevents Alzheimer's.
Next.
Boes

User ID: 77329196
Netherlands
08/27/2022 08:46 AM
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Re: Researchers are working on a vaccine that could prevent Alzheimer's disease
I know something much better. Don't take any vaccine at all.
Boes





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