NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency | |
Anonymous Coward User ID: 78381841 United Kingdom 02/03/2020 03:27 PM Report Abusive Post Report Copyright Violation | |
Baldrick
(OP) User ID: 76266446 Australia 02/03/2020 03:31 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency "THE PROBLEM" is not that it initially only kills mostly Asians, the REAL FUCKING PROBLEM is that it mutates in almost each new HOST, as is observed in European infected folks, which means.. it may just go "hyper" any time it feels "ready".. after all, it's a DESIGNED monster, right? Quoting: Anonymous Coward 78429069 Possible and see post up the page about that. We are in the fouth gen of this thing, and so far no indications it has mutated to entry by another receptor. Just going off what I can find v what I can understand. No expert. I might be barking up the wrong tree. Thanks!!! Much apreciated.. No worries. I dont understand much about it, thats a given. Looking at the numbers in the chart Germany is 23% and 18% in two studies. They are not through this yet, but reports are the case severity in individuals seem to be less. Keep an eye on Germany. Their gov is known for releasing accurate information. Blackadder: Baldrick, how did you manage to find a turnip that cost £400 000? Baldrick: Well, I had to haggle. |
Anonymous Coward User ID: 78343263 United States 02/03/2020 04:08 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency I am interested in the lethality of the virus on asians vs in other ethnic groups. Just because it makes everyone ill, it does not seem to be killing en masse as it is in China. And the virus has been in the US for months, it has spread all over the country by now. All of the "11 cases in the US" bullshit is ridiculous. Quoting: Anonymous Coward 76892169 ...as am I. My son is married to a 1/2 Asian woman. I have 2 grandkids that are 1/4 Asian, 1 boy, 1 girl. Son has already been sick with a horrible flu. Been over a week and he's still struggling. Worries me to death... |
Anonymous Coward User ID: 8826754 United States 02/03/2020 04:26 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Thread purpose: Quoting: Baldrick Compare this chart against the SARS outbreak by country. Why? Read below, tldr: The suggestion is the ACE2 receptors are the entry point for the nCoV, same as SARS Check the chart, interesting numbers. :ace2: Initial Source [link to twitter.com (secure)] And publisher [link to www.researchgate.net (secure)] Studies conducted around difference in outcome SARS found now - comparing 296 male female case subjects - all of asian decent [link to clinchem.aaccjnls.org] Published:January 30, 2020 Importantly, structural analysis suggests that 2019-nCoV might be able to bind to the angiotensin-converting enzyme 2 receptor in humans. The future evolution, adaptation, and spread of this virus warrant urgent investigation. [link to www.thelancet.com (secure)] Take what you want from this, but I find it interesting to note the ACE2 Genotype Frequency % to be much higher in the Asian population compared to ME population. Fair use applies to linked articles. Most excellent, thank you so much for all the detail and data! |
Baldrick
(OP) User ID: 76266446 Australia 02/03/2020 04:32 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency I am interested in the lethality of the virus on asians vs in other ethnic groups. Just because it makes everyone ill, it does not seem to be killing en masse as it is in China. And the virus has been in the US for months, it has spread all over the country by now. All of the "11 cases in the US" bullshit is ridiculous. Quoting: Anonymous Coward 76892169 ...as am I. My son is married to a 1/2 Asian woman. I have 2 grandkids that are 1/4 Asian, 1 boy, 1 girl. Son has already been sick with a horrible flu. Been over a week and he's still struggling. Worries me to death... Ill have look around for any studies on mixed ethnicity re ACE2, but ive yet to see it. Any reference ive seen is around country/population, probably to avoid the virulent "thats racist" liberal crowd. Keep in mind the SARS outbreak was 2003, so no doubt there has been a lot of research done around it since then. Tip: include the words "scholary articles" in google searches. Its dry reading, but bypasses MSM articles. Blackadder: Baldrick, how did you manage to find a turnip that cost £400 000? Baldrick: Well, I had to haggle. |
Prayandprepare000
User ID: 74409710 United States 02/03/2020 04:32 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 73778564 United States 02/03/2020 04:36 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency I am interested in the lethality of the virus on asians vs in other ethnic groups. Just because it makes everyone ill, it does not seem to be killing en masse as it is in China. And the virus has been in the US for months, it has spread all over the country by now. All of the "11 cases in the US" bullshit is ridiculous. Quoting: Anonymous Coward 76892169 One testing location. Backlog. Easy to explain the low numbers. |
Anonymous Coward User ID: 75517893 United States 02/03/2020 04:43 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency SARS uses ACE2 receptors as well, and I can tell you, PLENTY of white people caught SARS in Toronto. Quoting: Anonymous Coward 78198545 Number. R0 Ratios. Infected. Dead. Healed. Then compare it to it countries. Then refer to the chart in the OP Thats the plan man. Define "plenty" and dont stop there. You are in or out. Your call. The chart doesn't list African nations. |
Baldrick
(OP) User ID: 76266446 Australia 02/03/2020 04:45 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency SARS uses ACE2 receptors as well, and I can tell you, PLENTY of white people caught SARS in Toronto. Quoting: Anonymous Coward 78198545 Number. R0 Ratios. Infected. Dead. Healed. Then compare it to it countries. Then refer to the chart in the OP Thats the plan man. Define "plenty" and dont stop there. You are in or out. Your call. The chart doesn't list African nations. Doesnt list Australia either. But its all we got right now. Africa is going to be interesting, along with India. Blackadder: Baldrick, how did you manage to find a turnip that cost £400 000? Baldrick: Well, I had to haggle. |
Fluffy Pancakes
User ID: 54696528 United States 02/03/2020 04:46 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Very interesting information there, OP! Thank you much. I saw you referenced a lower percentage of ACE2 receptors to seemingly correlate to less severity of infection. But I didn't see if there was a study that indicated that was the case with SARS? My apologies if I missed it. I took a quick break and have to get back to work. But this is the thing that has been really begging for an answer in this entire ordeal. I feel for the people of China. We know it's far worse than their government is saying. There's no way the CCP would commit suicide by intentionally releasing this on their own people. I'm betting a lab failure. Not too dissimilar from the one in England that let out hoof and mouth. Thanks for this thread! 5 stars and green for thee! Things are bad enough, there is no need to make anything up. ~Fluffy "Never interrupt an enemy in the process of destroying himself." Quercitin and zinc...Get it. Take it. Visit howbad.info...If you took the shot, for sure. |
Anonymous Coward User ID: 78249238 United Kingdom 02/03/2020 04:47 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency "...it seems unlikely that the virus will spread widely in countries with vigorous, alert public health systems....every doctor in America has this top of his mind. Any patient with fever or respiratory problems will get two questions: Have you been to china? Have you been in contact with anyone who has?" That quote right there is evidence that our established medical field are doctors who cannot think for themselves, and that they only regurgitate what they learn in textbooks and are told As such most are useless at every arriving at any truth. how would any such system ever hope to detect that its source is not from some made up coronivus but something like the outbreak of symptoms from another cause? There was a dog cell flu vaccine that went out to the world this fall, including china. By asking only those two questions, our medical system is neither vigorous nor alert. The very same organisation that feeds us those tables of numbers. |
Baldrick
(OP) User ID: 76266446 Australia 02/03/2020 04:54 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Very interesting information there, OP! Thank you much. Quoting: Fluffy Pancakes I saw you referenced a lower percentage of ACE2 receptors to seemingly correlate to less severity of infection. But I didn't see if there was a study that indicated that was the case with SARS? Thank you. Not sure if any studies have framed the premise like that. But if you download this WHO paper on the 2003 SAR outbreak, you might find some insights. [link to apps.who.int (secure)] Last Edited by Baldrick on 02/03/2020 04:55 PM Blackadder: Baldrick, how did you manage to find a turnip that cost £400 000? Baldrick: Well, I had to haggle. |
Possum
User ID: 75926625 Australia 02/03/2020 04:57 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Howdy! Can someone please tell me what the gender configuration of the deaths for this virus are? - Chinese - Male/female - ages None of the articles or threads I have read give any of the above criteria - or maybe I am reading the wrong stuff!! There is no need for temples, no need for complicated philosophies. My brain and my heart are my temples; my philosophy is kindness. Dalai Lama Anyone who doesn't take truth seriously in small matters cannot be trusted in large ones either. Albert Einstein The kingdom of God is within you and all around you. It is not within buildings of wood or stone. Split a piece of wood and you will find me. Look beneath a stone and I am there. Stigmata |
Baldrick
(OP) User ID: 76266446 Australia 02/03/2020 04:59 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Howdy! Can someone please tell me what the gender configuration of the deaths for this virus are? Quoting: Possum - Chinese - Male/female - ages None of the articles or threads I have read give any of the above criteria - or maybe I am reading the wrong stuff!! Hey! Long time no see. Its in the OP Blackadder: Baldrick, how did you manage to find a turnip that cost £400 000? Baldrick: Well, I had to haggle. |
Possum
User ID: 75926625 Australia 02/03/2020 05:03 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Howdy! Can someone please tell me what the gender configuration of the deaths for this virus are? Quoting: Possum - Chinese - Male/female - ages None of the articles or threads I have read give any of the above criteria - or maybe I am reading the wrong stuff!! Hey! Long time no see. Its in the OP The OP? Baldrick my coffee has not kicked in yet - what is an OP? There is no need for temples, no need for complicated philosophies. My brain and my heart are my temples; my philosophy is kindness. Dalai Lama Anyone who doesn't take truth seriously in small matters cannot be trusted in large ones either. Albert Einstein The kingdom of God is within you and all around you. It is not within buildings of wood or stone. Split a piece of wood and you will find me. Look beneath a stone and I am there. Stigmata |
Anonymous Coward User ID: 76581188 United States 02/03/2020 05:06 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Thread purpose: Quoting: Baldrick Compare this chart against the SARS outbreak by country. Why? Read below, tldr: The suggestion is the ACE2 receptors are the entry point for the nCoV, same as SARS Check the chart, interesting numbers. :ace2: Initial Source [link to twitter.com (secure)] And publisher [link to www.researchgate.net (secure)] Studies conducted around difference in outcome SARS found now - comparing 296 male female case subjects - all of asian decent [link to clinchem.aaccjnls.org] Published:January 30, 2020 Importantly, structural analysis suggests that 2019-nCoV might be able to bind to the angiotensin-converting enzyme 2 receptor in humans. The future evolution, adaptation, and spread of this virus warrant urgent investigation. [link to www.thelancet.com (secure)] Take what you want from this, but I find it interesting to note the ACE2 Genotype Frequency % to be much higher in the Asian population compared to ME population. Fair use applies to linked articles. Lebanon level cost to lowest 7 about 1/3 that of Europe and and 1/7. Of Asians Who are genetically similar to Lebanese? Israelis |
Anonymous Coward User ID: 75517893 United States 02/03/2020 05:06 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency SARS uses ACE2 receptors as well, and I can tell you, PLENTY of white people caught SARS in Toronto. Quoting: Anonymous Coward 78198545 Number. R0 Ratios. Infected. Dead. Healed. Then compare it to it countries. Then refer to the chart in the OP Thats the plan man. Define "plenty" and dont stop there. You are in or out. Your call. The chart doesn't list African nations. Doesnt list Australia either. But its all we got right now. Africa is going to be interesting, along with India. India will be more interesting, because they have nukes, and well you know how India is when backed against a wall, Damn Gandhi... |
Anonymous Coward User ID: 75517893 United States 02/03/2020 05:07 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Thread purpose: Quoting: Baldrick Compare this chart against the SARS outbreak by country. Why? Read below, tldr: The suggestion is the ACE2 receptors are the entry point for the nCoV, same as SARS Check the chart, interesting numbers. :ace2: Initial Source [link to twitter.com (secure)] And publisher [link to www.researchgate.net (secure)] Studies conducted around difference in outcome SARS found now - comparing 296 male female case subjects - all of asian decent [link to clinchem.aaccjnls.org] Published:January 30, 2020 Importantly, structural analysis suggests that 2019-nCoV might be able to bind to the angiotensin-converting enzyme 2 receptor in humans. The future evolution, adaptation, and spread of this virus warrant urgent investigation. [link to www.thelancet.com (secure)] Take what you want from this, but I find it interesting to note the ACE2 Genotype Frequency % to be much higher in the Asian population compared to ME population. Fair use applies to linked articles. Lebanon level cost to lowest 7 about 1/3 that of Europe and and 1/7. Of Asians Who are genetically similar to Lebanese? Israelis That certainly does point to who would of made such a weapon. |
Anonymous Coward User ID: 76581188 United States 02/03/2020 05:10 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Thread purpose: Quoting: Baldrick Compare this chart against the SARS outbreak by country. Why? Read below, tldr: The suggestion is the ACE2 receptors are the entry point for the nCoV, same as SARS Check the chart, interesting numbers. :ace2: Initial Source [link to twitter.com (secure)] And publisher [link to www.researchgate.net (secure)] Studies conducted around difference in outcome SARS found now - comparing 296 male female case subjects - all of asian decent [link to clinchem.aaccjnls.org] Published:January 30, 2020 Importantly, structural analysis suggests that 2019-nCoV might be able to bind to the angiotensin-converting enzyme 2 receptor in humans. The future evolution, adaptation, and spread of this virus warrant urgent investigation. [link to www.thelancet.com (secure)] Take what you want from this, but I find it interesting to note the ACE2 Genotype Frequency % to be much higher in the Asian population compared to ME population. Fair use applies to linked articles. Lebanon level cost to lowest 7 about 1/3 that of Europe and and 1/7. Of Asians Who are genetically similar to Lebanese? Israelis Who did 9/11 Who did 3/11/11 Who did uss liberty? They think they can get away with ANYTHING at this point |
Travis Bickle
Vigilantes need love too.... User ID: 72715998 United States 02/03/2020 05:10 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency You're doing a hell of a job with the research! Thanks for this breakdown. (PS, I can't DM at the moment.... Waiting for this "Trial" upgrade to expire and then I'll go back to full member) One of these days... A *REAL* rain is gonna come and wash all this scum off the streets. |
Anonymous Coward User ID: 76581188 United States 02/03/2020 05:14 PM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 14675386 United Kingdom 02/03/2020 05:15 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Is this the virus that makes you have fever and chills for about 3 days, and a chest infection that last for a few weeks, well few days of yellow flem then clear whilst your lungs clear it. Also had shortness of breath... I thought it was the common cold... No biggie. Not scary. Just like a mild man flu. |
Anonymous Coward User ID: 14675386 United Kingdom 02/03/2020 05:19 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Im beginning to think that this virus hit London over new year. And people just complained about it being a chest infection and fever for a few days. What I'm saying is that maybe the symptoms are substantially less for Brits, especially those still in their 30s that eat meat and dairy and take good suppliments.. |
Anonymous Coward User ID: 76581188 United States 02/03/2020 05:19 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Would caution that level of ace2 receptors may not matter much If virus gets in it infects the cell Not sure a factor of 7 times more receptors means lung infection is 7 times more deadly |
Anonymous Coward User ID: 72736634 United States 02/03/2020 05:21 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency What this means is that the virus will not spread as quickly and can be more easily contained in White and Middle eastern countries. And those infected will have milder symptoms. This is exactly what we are seeing right now. Not a single non-Asian has died yet. |
Anonymous Coward User ID: 75470405 Australia 02/03/2020 05:22 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency The virus is only now old enough that we have more recoveries than deaths. It is still in its infancy. EVERY country is full of ground zero "victims" who have traveled across the world. Anything you want to claim is a week or more away from being proved and even then it starts with how many infected traveled there. If your claim is supported in a month or 2 I might give a crap. |
Anonymous Coward User ID: 72736634 United States 02/03/2020 05:24 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Would caution that level of ace2 receptors may not matter much Quoting: Anonymous Coward 76581188 If virus gets in it infects the cell Not sure a factor of 7 times more receptors means lung infection is 7 times more deadly No, what it means is that since there are less receptors, there is less opportunity for the virus to replicate in your body giving your immune system plenty of time to mount an offensive against it. Hence why white people who get it are having milder symptoms. If you have 7 times the receptors, then the virus is going to multiply much more quickly and overwhelm your immune system. So this absolutely is important to how the disease state plays out. |
Anonymous Coward User ID: 76185883 United States 02/03/2020 05:31 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency Its the Chinese. They suck at making copy cat purses etc. They stole this technology as well while using Asian RNA specifically to manufacture the weapon that got out. The militaries schedule for unleashing weapon on America was 2030. Maybe they just decided to wait to use Asian RNA once they mastered the art of their. Illogical warfare and aimed to use Asian version as a vaccine |
Anonymous Coward User ID: 77783149 United States 02/03/2020 05:32 PM Report Abusive Post Report Copyright Violation | Re: NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency "THE PROBLEM" is not that it initially only kills mostly Asians, the REAL FUCKING PROBLEM is that it mutates in almost each new HOST, as is observed in European infected folks, which means.. it may just go "hyper" any time it feels "ready".. after all, it's a DESIGNED monster, right? Quoting: Anonymous Coward 78429069 Possible and see post up the page about that. We are in the fouth gen of this thing, and so far no indications it has mutated to entry by another receptor. Just going off what I can find v what I can understand. No expert. I might be barking up the wrong tree. Thanks!!! Much apreciated.. No worries. I dont understand much about it, thats a given. Looking at the numbers in the chart Germany is 23% and 18% in two studies. They are not through this yet, but reports are the case severity in individuals seem to be less. :ace2: Keep an eye on Germany. Their gov is known for releasing accurate information. It seems as if the case severity so far is less almost everywhere outside of mainland China. Of course, the database is woefully inadequate at this point, so it is nearly impossible to perform any sort of scientific comparison. Also, it is painfully obvious that China tried to coverup the existence of its outbreak for at least a month and possibly longer. Also, they did not take drastic steps to try to contain the spread of the virus until it became obvious to both locals and the rest of the world that something was catastrophically wrong in Wuhan, China especially. Even before they ordered Wuhan citizens to wear protective masks and go into self-isolation, medical personnel, particularly paramedics, were suddenly appearing in full biohazard gear without explanation. Outside of China however, things are quite different. So far, no affected country is suffering from a medical infrastructure under extreme stress. And those who have traveled to China or have had contact with someone who has done so recently are acutely aware of the situation. This probably means that they seek treatment immediately after symptoms arise and in a healthcare system that is superior to what China has at the moment. In addition, we have had interesting reports such as Thai doctors treating their patients with antiviral drugs that are designed for HIV-positive patients and those with influenza, and reporting surprisingly good results. All of this shows that the widespread and continuous dispersal of truthful, accurate and helpful information dramatically improves the situation, whereas efforts to deceive are disastrous. Whether or not racial or ethnic genetics plays a role in immunity and survivability is also a critical unknown at this point but if so, this too must be revealed to the world populace at large and not shielded for reasons of "political correctness" or any other reason. |
Anonymous Coward User ID: 14675386 United Kingdom 02/03/2020 05:40 PM Report Abusive Post Report Copyright Violation | |