NCov-2019/SARS - ACE2 receptors (entry?) - the ANSWER to which COUNTRY/POPULATION has the most (and the least) frequency

I edited the OP. Check it out.

Still trying to understand it.

Yeah maybe you are completely totally 100% correct.

By day Im a logistics manager.

By night I immerse myself in shit I dont understand.

Not really understanding the roses analagy TBH.

Im not suggesting it targets Asians, and there are a lot of factors involved with the alarmingly rapid spread of our friendly CoV virus granted.

The premise isnt to prove it targets Asians. Its to demonstrate IF a correlation exists.

IF SARS didnt spread into populations with a lower ACE2 count, which had unsanitary conditions and with substandard health systems, it might mean something. And it might mean nothing as well.

Agree with susceptability, and it is too early to tell how nCoV-2019 will play out.

Im banking it is the result of a SARS vaccine China clinically trialled back in 2004, they tweeked it after seeing the result of the clinical trials (not good btw) and then when they thought it was good enough, distributed it through their health system.

Without telling anyone.

Have you seen the link to the Chinese 2004 SARS vaccine clinical trial?

[link to www.ncbi.nlm.nih.gov (secure)]

Israeli's are kind of like mutts. They have a Semitic base, but some admixture from Arab's, Mediterranean Caucasian's, Germanic's and maybe others.

If you want to view piblished papers

Widely researched

[link to www.researchgate.net (secure)]

Oh you are cheeky! I have long blonde hair, no wrinkles (great genes), athletic, and turned 50 last year, have European skin, & glamour modelled when I was in my 20s.

That is all I can provide - unless you live in Melbourne

Oh, l found this re data details:

80% of coronavirus victims are over 60, official says

From journalist Isaac Yee in Hong Kong and CNN’s Lily Lee in Beijing
The death rate from the Wuhan coronavirus across mainland China stands at 2.1%, China’s National Health Commission said in a press update on Tuesday.

In Hubei province, the epicenter of the outbreak, the rate is 3.1%, said Jiao Yahui, deputy director of the National Health Commissions State Health Administration.

Hubei province accounts for 97% of all deaths.

Of the 425 confirmed deaths across mainland China, 80% of the victims were over the age of 60, and 75% of victims had some form of underlying disease, Jiao added. Two-thirds of the confirmed deaths are male.

[link to edition.cnn.com (secure)]


2/3 rds are mâle!!!!!!!!!!

I do not watch CNN - truly bad channel!!!!!!

Could it just (just not the best word) that people with higher ACE2 receptors have a higher R0 value.

We all have ACE2 receptors - does it say anywhere why some groups have more?

Im putting aside R0 for now.

Leaning towards higher ACE2 is higher viral load with quicker onset.

Combibed with

May be a link with a China 2005 clinical trial of SARS vaccine that proceeded into production and deplyment.

Demonstrated that when vaccinated test animal had a wild CoV introduced, the vaccinated animal viral load went through the roof.

Good info here to start with

Keep safe, and any eyes on the gound my much appreciated



[link to jameslyonsweiler.com (secure)]

Melbourne eh?

Id take anything CNN says, along with all MSM, with a grain of salt re current numbers.

Re male/female stats, thats been put to bed for now. There is no way to determine that stat, and the over 60 is a misdirection from 23 Jan
U

Shit! So i still don't have the numbers - and if China are crematiing how will we ever know the real figures ?

interesting theory !

Agent smith, are you factoring in any info about the sudanese?

USPS, FEDEX, UPS, etc... all those holiday deliveries... amazon distribution centers, etc. Any word on their exposure?

What word on their exposure are you hoping for? all we know are fake infected counts, and they do not release any info about anything, not to mention their place of work. so not sure what you think you would get.

23% death rate on asians

10% on whites

absolute conjecture. i asked a relevant question about the sudanese, does no one else actually want to get this figured out?

No, I actually have a degree in biochemistry. This was very interesting - Thank you. It actually wasn't a clinical trial, but was research into biochemical mechanisms of SARs S-protein mediation of virus entry into human cells. It suggests ACE2 is the intermediary that facilitates this, and that a virus could potentially be produced that inhibits it.

What it doesn't do is suggest that Asian phenotypes of ACE2 may be more susceptible to binding of the SARs virus. The take-away is that ACE2 is a key ingredient in the process. All of us have ACE2 at concentration ranges that help control blood pressure and produce angiotensin II in our serum mainly at the lungs. We all have ACE2 in concentration ranges that keep things in equilibrium and control vasodilation. It's the same in all ethnicities.

If it is an "equal opportunity infector", then all ethnic groups will get infected equally. It seems that after initial infection, as suggested earlier, another component takes over the main infection. Maybe that component is related to the HIV-inserts into the virus's genome...

I can't post links anymore.

Instead i have this :

In accordance with industry accepted best practices we ask that users limit their copy / paste of copyrighted material to the relevant portions of the article you wish to discuss and no more than 50% of the source material, provide a link back to the original article and provide your original comments / criticism in your post with the article.

And an "original message" as proof.
But i have not posted that message.
What is going on?

Bingo! There's only 1 reason to insert HIV sequences into something like this - financial gain. There's only 2 ways to achieve that - try to develop a commercially viable vaccine, or try to make something of military usefulness. Anyone's guess which one this was. HIV sequences may lower immune efficacy and enhance communicability and binding to the receptor. Putting this in an airborne virus would make it a potential stock for military purposes. A lot more is going to become known about this one, and there is considerable reason for grave concern.

" Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration. The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90uM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500mg administration."

link: no link possible

Bump

Wait wait wait. Hold on. What if you're taking ACE inhibitors for high blood pressure?

That's a great question...

I wonder what affect that would have on Virus transmission.